Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for synthesizing houttuynin Schiff base and copper complex thereof

A technology of houttuyfonate and copper complexes, which is applied in the preparation of copper organic compounds, imino compounds, organic chemistry, etc., can solve the problems of rare articles, and achieve the effects of convenient operation, high yield and good stability

Inactive Publication Date: 2019-08-06
HUNAN NORMAL UNIVERSITY
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, articles combining houttuyfotin with other substances in the form of chemical bonds are rare

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for synthesizing houttuynin Schiff base and copper complex thereof
  • Method for synthesizing houttuynin Schiff base and copper complex thereof
  • Method for synthesizing houttuynin Schiff base and copper complex thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Step 1. Synthesis of Schiff base C 24 h 44 o 2 N 2

[0053] Ⅰ. Dissolve 0.2740g (1mmol) sodium octanoyl acetaldehyde sulfite in 60mL of 5%-20% ethanol solution, condense and reflux magnetically for 0.5h under the condition of heating in a water bath. g 1,4-Butanediamine (1 mmol). 40°C water bath condensation reflux magnetic stirring 0.5-3h.

[0054] II. Cool the reaction solution in step I to room temperature, filter, and wash the filter cake three times with distilled water. The filter cake was vacuum-dried to obtain Schiff's base. The yield is about 89%.

[0055] (1)C 24 h 44 o 2 N 2 Infrared characterization of

[0056] C 24 h 44 o 2 N 2 For the infrared spectrum, see figure 1 (Instrument model: NEXUS infrared spectrometer). Compared with the raw material octanoylacetaldehyde sodium sulfite, C 24 h 44 o 2 N 2 In the infrared spectrum, at 1646cm -1 A new peak appears at , which is the stretching vibration peak of C=N, indicating the formation of...

Embodiment 2

[0066] Step 1. Synthesis of Schiff base C 28 h 52 o 2 N 2

[0067] Ⅰ. Dissolve 0.3020g (1mmol) houttuyfonate sodium in 60mL of 5%-20% ethanol solution, condense and reflux magnetically for 0.5h under the condition of heating in a water bath. 0.0882g 1,4-Butanediamine (1mmol). Condensate in a water bath at 40°C and stir magnetically for 0.5-3h.

[0068] II. Cool the reaction solution in step I to room temperature, filter, and wash the filter cake three times with distilled water. The filter cake was vacuum-dried to obtain Schiff's base. The yield is about 88%

[0069] (1)C 28 h 52 o 2 N 2 Infrared characterization of

[0070] C 28 h 52 o 2 N 2 For the infrared spectrum, see image 3 (Instrument model: NEXUS infrared spectrometer). Compared with raw material houttuyfonate sodium, C 28 h 52 o 2 N 2 In the infrared spectrum, at 1647cm -1 A new peak appears at , which is the stretching vibration peak of C=N, indicating the formation of a Schiff base; 1036cm -...

Embodiment 3

[0079] Step 1. Synthesis of Schiff base C 32 h 60 o 2 N 2

[0080] Ⅰ. Dissolve 0.3300g (1mmol) neohouttuyfonate sodium in 60mL of 5%-20% ethanol solution, condense and reflux magnetically for 0.5h under the condition of heating in a water bath. 0.0882 g of 1,4-butanediamine (1 mmol) was added dropwise. Condensation and reflux magnetic stirring for 0.5-3h under the condition of water bath heating.

[0081] II. Cool the reaction solution in step I overnight, filter, and wash the filter cake three times with distilled water. The filter cake was vacuum-dried to obtain Schiff's base. The yield is about 86%

[0082] (1)C 32 h 60 o 2 N 2 infrared characterization. (Instrument model: NEXUS infrared spectrometer)

[0083] C 32 h 60 o 2 N 2 For the infrared spectrum, see Figure 5 .C 32 h 60 o 2 N 2 In the infrared spectrum, at 1647cm -1 A new peak appears at , which is the stretching vibration peak of C=N, indicating the formation of a Schiff base; 1040cm -1 , 1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Houttuynin is the main extract in the volatile oil of Houttuynia cordata, and has excellent antibacterial, antiviral and anti-inflammatory effects, so the houttuynin can be widely applied to medicines. The chemical properties of the houttuynin are unstable, so the medical application of the houttuynin is limited, so it is necessary to carry out chemical modification to synthesize a series of new compounds reserving the original active structure in order to obtain a compound with high activity. Sodium houttuyfonate and its homologues octanoyl acetal sodium sulfite and sodium new houttuyfonate,which are used as raw materials, are chemically modified on the basis of reserving the active group carbonyl group to obtain novel compounds with high or extensive bioactivity, so the future studyingof houttuynin drugs is benefited. The invention discloses a method for synthesizing a series of houttuynin 1,4-butanediamine Schiff bases with different carbon chain lengths, and a copper complex thereof. The formula of the Schiff base is C4H8N2(CnH2n+1)2.

Description

technical field [0001] The invention relates to the field of transition metal complex materials, in particular to a method for preparing houttuyfonate 1,4-butanediamine Schiff bases with different carbon chain lengths and copper complexes thereof. The Schiff base and its complex specifically relate to medicine and may be used in the preparation of antibacterial, antibacterial and anti-inflammatory series drugs. Background technique [0002] Houttuynia cordata is a kind of medicinal herb included in the Chinese Pharmacopoeia. It is called Houttuynia cordata because of its fishy smell after the stems and leaves are crushed. According to research, Houttuynia cordata contains decanoyl acetaldehyde, which has antibacterial activity. However, the pharmacological effect of houttuyonin is relatively simple, so it is very important to study the synergistic effect of houttuyonin and other drugs. In the current research, there are many reports on mixing houttuyfonate preparations wit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C251/08C07C249/02C07F1/08
CPCC07C249/02C07F1/08C07C251/08
Inventor 胡瑞祥耿海燕张漫波
Owner HUNAN NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com