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Mango couth suppressing capsule and method of preparatuion long effect capsule

A mango and capsule technology, which is applied in the field of preparation of mango cough long-acting capsules, can solve problems such as slow dissolution, decreased tablet content, and impact on bioavailability

Inactive Publication Date: 2005-01-05
徐小彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, tablets also have many disadvantages: ① Some excipients need to be added to the tablet, and after compression molding, the dissolution rate is slower than that of powder and capsule, which sometimes affects its bioavailability; ② Children and comatose people are not easy to swallow; ③ Tablets containing volatile components decreased in storage compared to
Due to technical limitations, mango cough tablets are ordinary tablets when the drug is submitted for approval, and its relative bioavailability is low, which cannot meet the needs of high-quality treatment of diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Extract 100 kg of fresh mango leaves twice with 10 times and 8 times of water respectively, the first time is 2 hours, the second time is 1-1.5 hours, the water extracts are combined, filtered, concentrated and dried at low temperature to obtain mango paste, which is crushed finely Powder for later use, then add 0.033 kg of houttuyfonate sodium and 0.0021 kg of chlorpheniramine per kg of mango leaf powder and mix evenly, add adhesive to make microcapsules, coat with spermaceti or other blockers, and separate Made 2, 4, 6, 8 hour slow-release pellets, each pellet is distinguished by different colors, mixed evenly, packed into empty capsules, packed into boxes or hot-pressed into aluminum-plastic plates to obtain products.

Embodiment 2

[0040] Extract 100 kg of fresh mango leaves twice with 10 times and 8 times of water respectively, combine the decoction for the first 2 hours and the second 1-1.5 hours, filter, concentrate the filtrate and return the clear paste with a specific gravity of 1.15, let it cool, Add ethanol to make the alcohol content reach 65%, let it stand for 48 hours, filter the filtrate to recover ethanol, thicken it into a thick paste with a specific gravity of 1.25, then dry it at low temperature, crush it to obtain a fine powder, and then add 0.05 kg per kg of mango leaf powder Houttuyfonate sodium plus 0.0042 kg of chlorpheniramine, mix well, add adhesive to make microcapsules, coat with spermaceti or other blockers, and make 2, 4, 6, 8 hour slow-release pellets respectively , each pellet is distinguished by different colors, mixed evenly, put into an empty capsule, packed into a box or hot-pressed into an aluminum-plastic plate to obtain the product.

Embodiment 3

[0042] Extract 100 kg of fresh mango leaves twice with 10 times and 8 times of water respectively, combine the decoction for the first 2 hours and the second 1-1.5 hours, filter, concentrate the filtrate and return the clear paste with a specific gravity of 1.15, let it cool, Add 8% 101-type clarifier, let it stand for 48 hours, filter, the filtrate is concentrated into a thick paste with a specific gravity of 1.25, then dry at low temperature, crush to obtain a fine powder, and then add 0.05 kg of Houttuynia cordata per kg of mango leaf powder Su sodium plus 0.0042 kg of chlorpheniramine are mixed evenly, added with adhesive to make microcapsules, coated with spermaceti or other blockers, and made into 2, 4, 6, and 8-hour sustained-release pellets respectively. Each pellet Distinguish by different colors, mix them evenly, put them into empty capsules, pack them into boxes or heat-press them into aluminum-plastic panels to get the product.

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Abstract

A medicine in the form of capsules for treating cough with durable effect is prepared through extracting active components from fresh mango fruit, proportional mixing with sodium houttuyfonate and chlorpheniramine, granulating and loading in capsules.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a preparation method of mango cough long-acting capsules with sustained release. Background technique [0002] The dosage forms of Chinese patent medicines have been developed for many years, and there are ointments, powders, pills, syrups, tablets, capsules, injections, granules and other dosage forms. These dosage forms have their own advantages, which have opened up space for the development of Chinese patent medicines. [0003] Tablet is a common form of Chinese patent medicine, and it has the following advantages: ①Usually, the dissolution rate and bioavailability of tablets are better than those of pills: ②The dosage is accurate, and the difference in drug content in the tablet is small; Solid, and some drugs that are prone to oxidative deterioration and deliquescence can be protected by coating, and light, air, moisture, etc. have little influence on them; ④It...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61P11/14
Inventor 徐小彬
Owner 徐小彬
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