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Application of new sodium houttuyfonate injection in treating milk cow mastitis

A technology of new houttuybein sodium injection, which is applied in the application field of new houttuybein sodium injection in the treatment of dairy cow mastitis, and can solve the problems of new houttuybein sodium injection that have not been seen yet. Achieve the effects of simple preparation method, convenient operation and broad application prospect

Inactive Publication Date: 2011-02-23
商丘市康森动物药品研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the application of new Houttuyfonate Sodium Injection in the treatment of dairy cow mastitis in the open literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the preparation of new houttuyfonate sodium injection

[0017] Weigh 2% neohouttuyfonate sodium, 2% hydroxypropyl-β-cyclodextrin and 10% water for injection, fully mix, grind evenly; add 50% water for injection (containing 0.05% sodium benzoate) and stir evenly; 35% citrate buffer solution to adjust the pH to 4.5; add water for injection to the full amount; add 0.05% activated carbon to stir and adsorb to remove pyrogens, decarbonize and filter; The cap is sealed and packaged in a sterilized package, that is, New Houttuyfonate Sodium Injection.

Embodiment 2

[0018] Embodiment 2, the preparation of new houttuyfonate sodium injection

[0019] Weigh 5% neohouttuyfonate sodium, 20% hydroxypropyl-β-cyclodextrin and 20% water for injection, fully mix, grind evenly; add 40% water for injection (containing 0.1% sodium benzoate) and stir evenly; 15% citrate buffer solution to adjust the pH to 5.0; add water for injection to the full amount; add 0.1% activated carbon to stir and adsorb to remove pyrogens, decarbonize and filter; The cap is sealed and packaged in a sterilized package, that is, New Houttuyfonate Sodium Injection.

Embodiment 3

[0020] Embodiment 3, the preparation of new houttuyfonate sodium injection

[0021] Take by weighing 10% neohouttuyfonate sodium, 40% hydroxypropyl-β-cyclodextrin and 20% water for injection, fully mix, grind evenly; add 20% water for injection (containing 0.1% sodium benzoate) and stir evenly; 10% citrate buffer solution to adjust the pH to 6.0; add water for injection to the full amount; add 0.5% activated carbon to stir and adsorb to remove pyrogens, decarbonize and filter; The cap is sealed and packaged in a sterilized package, that is, New Houttuyfonate Sodium Injection.

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PUM

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Abstract

The invention discloses a new sodium houttuyfonate injection and a preparation method thereof, which are used for treating milk cow mastitis and belong to the technical field of animal remedies. The sodium houttuyfonate injection comprises the following components in percentage by weight: 0.01 to 10 percent of new sodium houttuyfonate, 0.1 to 50 percent of solubilizing agent, 0.1 to 50 percent of pH modifying agent, and 0.01 to 0.5 percent of antioxidant. The preparation method comprises the following steps of: fully mixing the new sodium houttuyfonate with the solubilizing agent, and then uniformly grinding the mixture; adding aqueous solution of the antioxidant to adjust the pH to be 4.5 to 6.5; adding activated carbon to remove pyrogen; decarburizing and filtering the mixture; filtering the mixture for degermation by using 0.22 mum microporous filter membrane terminal; and performing nitrogen-filling and sub-package, capping sealing, and sterilized packaging to obtain the injection. The new sodium houttuyfonate injection has a simple formula, safe quality and high stability; and the preparation process is simple and feasible, is convenient to operate, is low in cost, is suitable for industrial production, and has an extensive prospect.

Description

technical field [0001] The invention relates to a new houttuyfonate sodium injection, and at the same time, the invention also relates to a preparation method of the new houttuyfonate sodium injection and its application in treating cow mastitis, belonging to the technical field of veterinary medicine. Background technique [0002] Dairy cow mastitis is the most common concomitant disease caused by multiple factors in adult dairy cows. Despite years of research, it is still one of the most harmful and costly diseases in dairy cattle breeding. Features such as high rate. About 1 / 3 of dairy cows in the world suffer from various mastitis, and the economic loss caused by mastitis is as high as 35 billion yuan every year. At present, antibiotics are mostly used in the treatment of dairy cow mastitis, but long-term and large-scale use will cause mammary gland sclerosis and reduce milk production capacity. Antibiotic residues in milk have caused a great threat to human health. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/121A61P15/14
Inventor 饶刚李逐波廖丹丹徐高贤徐泽民
Owner 商丘市康森动物药品研究所
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