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Application of sodium houttuyfonate as synergist of antifungal medicament

An antifungal drug, the technology of Houttuyfonate Sodium, which is applied in the field of medicine to achieve the effect of reducing toxic side effects and treating fungal infections

Inactive Publication Date: 2011-12-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report that houttuyfonate sodium can be used as a synergist of azole and polyene antifungal drugs

Method used

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  • Application of sodium houttuyfonate as synergist of antifungal medicament
  • Application of sodium houttuyfonate as synergist of antifungal medicament
  • Application of sodium houttuyfonate as synergist of antifungal medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Effects of combined use of houttuyfonate sodium and fluconazole on different clinical fungal strains.

[0012] Materials and methods

[0013] 1. Test drug:

[0014] Houttuyfonate Sodium: Wuhan Hezhong Biochemical Manufacturing Co., Ltd.

[0015] Fluconazole: Pfizer Pharmaceuticals Ltd.

[0016] Dimethyl sulfoxide: China Pharmaceutical (Group) Shanghai Chemical Reagent Company.

[0017] Houttuyfonate sodium was formulated with dimethyl sulfoxide to a concentration of 8 mg / ml, and the concentration of fluconazole was 2 mg / ml, and the test drug was stored at -20°C. Before the experiment, the drug stock solution was taken out and placed in a 35°C incubator to melt, fully mixed, and the pharmacodynamic test was carried out respectively.

[0018] 2. Strains:

[0019] The clinical strains of Candida albicans, Candida krusei and Microsporum lanoides were provided by the fungal laboratory of Shanghai Changhai Hospital, and were identified by morphology and bioche...

Embodiment 2

[0048] Example 2: Effects of houttuyfonate sodium combined with fluconazole on different clinical and laboratory-induced drug-resistant strains

[0049] Materials and methods

[0050] 1. Test drug:

[0051] Houttuyfonate Sodium: Wuhan Hezhong Biochemical Manufacturing Co., Ltd.

[0052] Fluconazole: Pfizer Pharmaceuticals Ltd.

[0053]Dimethyl sulfoxide: China Pharmaceutical (Group) Shanghai Chemical Reagent Company.

[0054] Houttuyfonate sodium was formulated with dimethyl sulfoxide to a concentration of 8 mg / ml, and the concentration of fluconazole was 2 mg / ml, and the test drug was stored at -20°C. Before the experiment, the drug stock solution was taken out and placed in a 35°C incubator to melt, fully mixed, and the pharmacodynamic test was carried out respectively.

[0055] 2. Strains:

[0056] Clinical drug-resistant strains: Candida albicans were provided by the Fungi Department of Shanghai Changhai Hospital, and were identified by morphology and biochemistry.

...

Embodiment 3

[0065] Example 3: Combination of houttuyfonate sodium with miconazole and ketoconazole

[0066] Materials and methods

[0067] 1. Test drug:

[0068] Houttuyfonate Sodium: Wuhan Hezhong Biochemical Manufacturing Co., Ltd.

[0069] Fluconazole: Pfizer Pharmaceuticals Ltd.

[0070] Ketoconazole: National Institute for the Control of Pharmaceutical and Biological Products.

[0071] Miconazole: National Institute for the Control of Pharmaceutical and Biological Products.

[0072] Dimethyl sulfoxide: China Pharmaceutical (Group) Shanghai Chemical Reagent Company.

[0073] Dimethyl sulfoxide was used to prepare Houttuydin Sodium to a concentration of 8 mg / ml, and Miconazole and Ketoconazole were prepared to a concentration of 6.4 mg / ml by dimethyl sulfoxide, respectively, and the tested drugs were stored at -20°C. Before the experiment, the drug stock solution was taken out and placed in a 35°C incubator to melt, fully mixed, and the pharmacodynamic test was carried out respect...

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Abstract

The invention relates to the technical field of medicaments, in particular to novel application of sodium houttuyfonate as a synergist of an antifungal medicament. The antifungal medicament is an azole or polyene antifungal medicament; and 1 to 16mu g of sodium houttuyfonate is added into each 1ml of antifungal medicament. Experiments prove that: when the sodium houttuyfonate is combined with theantifungal medicament such as fluconazole, ketoconazole, miconazole or amphotercin B, and the like, the treatment effect of the sodium houttuyfonate on superficial or deep fungal infection can be ensured under the condition of reducing the dosage and the sodium houttuyfonate can make the antifungal medicament recover the effect on medicament-resistant fungi, so the sodium houttuyfonate can be used as the synergist of the antifungal medicament. The sodium houttuyfonate serving as the synergist of the antifungal medicament can reduce the dosage of the azole or polyene antifungal medicament so as to reduce the toxic and side effects of the medicament; and particularly, the sodium houttuyfonate makes the antifungal medicament recover the effect on the medicament-resistant fungi, effectively treats fungal infection, particularly medicament-resistant fungal infection, and has important clinical application value.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new application of houttuyfonate sodium as a synergist for antifungal drugs. Background technique [0002] Azole (including imidazoles, triazoles) and polyene antifungal drugs are clinically commonly used antifungal drugs that can effectively treat deep and superficial fungal infections, such as ketoconazole and clotrimazole in imidazoles , miconazole, econazole, etc.; fluconazole, itraconazole, voriconazole, etc. in triazoles; amphotericin B in polyenes, etc. However, due to well-known reasons, clinical drug-resistant strains are becoming more and more common, resulting in the need to increase the dosage, and some antifungal drugs are ineffective even by increasing the dosage. Increasing the dosage will inevitably increase the toxic and side effects, especially drugs such as ketoconazole and other toxic side effects on the liver or heart, thereby limiting the clinical applicat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/185A61P31/10A61K31/4196A61K31/496A61K31/4174A61K31/7048
Inventor 曹颖瑛商庆华朱臻宇鹿辉傅子晋柴逸峰姜远英
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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