65 results about "Pyrazolone derivatives" patented technology

The object of the present invention is to provide a medicament useful for preventing and / or treating inflammatory bowel disease. The present invention provides a medicament for preventing and / or treating inflammatory bowel disease which comprises as an active ingredient a pyrazolone derivative represented by the following formula (I) or a physiologically acceptable salt thereof, or a hydrate thereof or a solvate thereof: wherein R<1> represents a hydrogen atom, an aryl group, an alkyl group, or an alkoxycarbonylalkyl group; R<2> represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group or a hydroxyalkyl group; or R<1> and R<2> are combined with each other to represent an alkylene group; and R<3> represents a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, a benzyl group, a naphthyl group, a phenyl group, or a phenyl group substituted with 1 to 3 substituents selected from the group consisting of an alkyl group, an alkoxy group, a hydroxyalkyl group, an alkoxycarbonyl group, an alkylmercapto group, an alkylamino group, a dialkylamino group, a halogen atom, a trifluoromethyl group, a carboxyl group, a cyano group, a hydroxyl group, a nitro group, an amino group and an acetamide group.

The invention belongs to an organic photochromic material, and relates to preparations and applications of a thienyl group-containing pyrazolone derivative and its polymer film. The thienyl group-containing pyrazolone derivative is anyone of 1-phenyl-3-substituted-phenyl / thienyl / pyrryl / furyl / pyridyl / naphthyl-4-thienylmethylene-5-hydroxypyrazolone phenylsemicarbazone / methylthiosemicarbazide / ethylthiosemicarbazide / thiosemicarbazide or 1-phenyl-3-thienyl-4-subsituted-phenylmethylene / thienylmethylene / pyrrylmethyl / furylmethylene / pyridylmethylene / naphthylmethylene-5-hydroxypyrazolone phenylsemicarbazone / methylthiosemicarbazide / ethylthiosemicarbazide / thiosemicarbazide, and the polymer is anyone of polystyrene, polymethylstyrene, polyethylene and polypropylene. The thienyl group-containing pyrazolone derivative and its polymer film can be used in the information storage field, the molecular switch field, the false proof field, the optical eyeglass field, the intelligent window field and the like.

The invention discloses a pyranopyrazole acrylate derivative, a preparation method and application thereof. The preparation method of this type of derivative is as follows: the MBH carbonate containing quinoline heterocycle as shown in formula (II), the pyrazolone derivative shown in formula (III) are mixed with solvent, add chiral phosphine catalyst and The base is stirred and reacted to prepare the pyranopyrazole acrylate derivatives shown in the formula (I). The method of the present invention has the characteristics of easy-to-obtain raw materials, simple and convenient operation, high chemical selectivity and regioselectivity, and the target compound is effective against human colon cancer cell HT-29, human non-small cell lung cancer cell A549, and triple-negative breast cancer cell MDA-MB-231. It has better effect of inhibiting proliferation in vitro, therefore, the method of the present invention has great implementation value and application prospect.