Preventive and/or therapeutic drugs for inflammatory intestinal diseases

Abstract

The object of the present invention is to provide a medicament useful for preventing and / or treating inflammatory bowel disease. The present invention provides a medicament for preventing and / or treating inflammatory bowel disease which comprises as an active ingredient a pyrazolone derivative represented by the following formula (I) or a physiologically acceptable salt thereof, or a hydrate thereof or a solvate thereof: wherein R<1> represents a hydrogen atom, an aryl group, an alkyl group, or an alkoxycarbonylalkyl group; R<2> represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group or a hydroxyalkyl group; or R<1> and R<2> are combined with each other to represent an alkylene group; and R<3> represents a hydrogen atom, an alkyl group, a cycloalkyl group, a hydroxyalkyl group, a benzyl group, a naphthyl group, a phenyl group, or a phenyl group substituted with 1 to 3 substituents selected from the group consisting of an alkyl group, an alkoxy group, a hydroxyalkyl group, an alkoxycarbonyl group, an alkylmercapto group, an alkylamino group, a dialkylamino group, a halogen atom, a trifluoromethyl group, a carboxyl group, a cyano group, a hydroxyl group, a nitro group, an amino group and an acetamide group.

Description

technical field [0001] The present invention relates to a drug for preventing and / or treating inflammatory bowel disease, an intestinal mucosal protective agent, and neutrophils containing pyrazolone derivatives or physiologically acceptable salts thereof, or hydrates or solvates thereof as active ingredients Activation inhibitors, and myeloperoxidase activity inhibitors. Background technique [0002] Inflammatory Bowel Disease (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) have various causes, such as bacterial infection theory, autoimmune abnormality theory, etc. , but the reason for this is still unclear. However, since its incidence is increasing as civilization advances, it has been shown to be associated with environmental factors such as mental stress. For its treatment, oral, adrenal corticosteroid (prednisolone) containing sulfasalazine (Sakazosulfapyridine) or aminosalicylic acid (for example, 5-aminosalicylic acid) as active ingredients are mainl...

AI Technical Summary

Problems solved by technology

As noted above, although superoxide anion, free radicals such as hydroxyl radicals, or hydrogen peroxide from macrophages and leukocytes have been shown to be associated with the development of ulcerative colitis, edara has not been studied Report on whether Bong is effective for inflammatory bowel disease

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