55 results about "Hydroxylamine derivatives" patented technology

A method of increasing expression of a molecular chaperon by a cell and / or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and / or cosmetical compositions comprising the said compounds.

The present invention provides antioxidants made of an aromatic hydroxyamine derivative having a structure represented by the general formula (I): wherein R1, R2 and R3 are each independently a hydrogen atom or an alkyl group having 1 to 20 carbon atoms; X is a hydrogen atom or an OH group; Y is a hydrogen atom or an NHR1 group; A is a direct bond, —O—, —NH—, —SO2—, —CH2— or —C(CH3)2—, and when an OH group and an NHR1 group are introduced to a unilateral benzene ring, these groups are respectively bonded to adjacent positions of the benzene ring; and n is 0 or 1 with the proviso that when n is 0, R1 is not a hydrogen atom, as well as bisaminophenol derivatives represented by the above general formula (I) wherein n is 1; R2 and R3 are each a hydrogen atom; X is an OH group; Y is an NHR1 group; A is —C(CH3)2—; and R1 is isopropyl, isobutyl or isohexyl. The aromatic hydroxyamine derivatives having a structure represented by the general formula (I), in particular, the bisaminophenol derivatives as novel substances, exhibit an excellent oxidation-inhibiting property, and are usable as antioxidants or polymerization inhibitors.

A composition for removing undesired matter from a substrate, the composition comprising hydroxylamine or a hydroxylamine derivative, a quaternary ammonium compound and at least one polar organic solvent. The composition is capable of removing photoresist from wafer level packaging and solder bumping applications.

The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. In another aspect, the instant invention provides methods of treating or preventing peripheral nervous system neuropathies. Peripheral nervous system neuropathies may but need not be diabetic neuropathies, and may but need not be associated with a diabetic wound. The invention also provides pharmaceutical compositions comprising a certain hydroxylamine derivative or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. In certain compositions and methods, the additional therapeutic agent is a second hydroxylamine derivative or a pharmaceutically acceptable salt thereof.

The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Disclosed are: a processing agent composition for semiconductor surfaces, which is capable of easily removing an antireflective film layer, a resist layer and a resist cured layer in a short time during the production procedure of a semiconductor element or the like; and a method for processing a semiconductor surface, which is characterized by using the processing agent composition. Specifically disclosed is a processing agent composition for semiconductor surfaces, which is characterized by containing (I) a compound which generates fluorine ions in water, (II) a carbon radical generator, (III) water, (IV) an organic solvent and (V) at least one compound selected from the group consisting of hydroxylamines and hydroxylamine derivatives represented by general formula (1). Also specifically discloses is a method for processing a semiconductor surface, which is characterized by using the processing agent composition. (In the formula, R1 represents a linear, branched or cyclic alkyl group with 1-6 carbon atoms or a linear or branched substituted alkyl group with 1-4 carbon atoms having 1-3 hydroxyl groups; and R2 represents a hydrogen atom, a linear, branched or cyclic alkyl group with 1-6 carbon atoms or a linear or branched substituted alkyl group with 1-4 carbon atoms having 1-3 hydroxyl groups).

The invention discloses a treatment solution for reducing the oxidation films on the surfaces of copper and copper alloys and a treatment method thereof. In the treatment solution, one or more of ascorbic acid, hypophosphite, glucose, hydrazine, hydrazine derivatives, hydroxylamine and hydroxylamine derivatives are used as reducing agents to reduce the oxygen element in the oxidation films formedon the surfaces of copper and copper alloys and keep the copper element. The treatment solution has the following advantages: the acid fog with a lot of H2, NO2 and the like can not generated in the reduction treatment to seriously influence the fitness of the operator; and after treatment, the copper ion content of the treatment solution is less than 0.5mg / l, thus the water treatment system can not be polluted; and the treatment solution is environmentally-friendly. In addition, the oxidation films formed on the surfaces of copper and copper alloys can be reduced to bright copper and copper alloys in only 1-5 minutes, thus the treatment solution is the treatment solution with low cost,, high treatment speed, remarkable effect and environmental friend and has good market application prospect, and the method is convenient to use.

A composition for removing undesired matter from a substrate, the composition comprising hydroxylamine or a hydroxylamine derivative, a quaternary ammonium compound and at least one polar organic solvent. The composition is capable of removing photoresist from wafer level packaging and solder bumping applications.

The invention discloses an N-hydroxy ester preparation method. According to the method, an aldehyde derivative and a hydroxylamine derivative are adopted as reaction substrates, iodide is adopted as an accelerant, tertbutyl alcohol hydrogen peroxide is adopted as an oxidant, and then N-hydroxy ester is prepared through diradical cross coupling reaction. The chemical structural formula of the aldehyde derivative is shown in the description, and in the formula, R1 is naphthyl, alkyl or monosubstituted aryl; and the iodide is sodium iodide NaI, potassium iodide KI, cuprous iodide CuI, lithium iodide LiI, iodine I2, tetrabutyl ammonium iodide, or tetraheptylammonium iodide. As the iodide is adopted as the accelerant, the N-hydroxy ester is prepared by using a diradical cross coupling method, and the traditional expensive high-toxicity metal accelerant and a traditional cumbersome experiment method are not used, the reaction is simpler, more convenient, more feasible, safer, more environment-friendly and more economical, the reaction conditions are quite mild, and the aftertreatment is simpler.

The invention relates to the field of pharmaceutical chemistry, in particular to substituted hydroxylamine derivatives. The invention also discloses a preparation method for the substituted hydroxylamine derivatives, a medicinal composition comprising the compounds, and the application of the compounds in treating rheumatoid arthritis and osteoarthritis, and treating other diseases and symptoms through doubly inhibiting cyclooxygenase-2(COX-2) and 5-lipoxygenase (5-LOX).

The present invention provides methods of treating stroke comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. The invention also provides pharmaceutical compositions comprising a certain hydroxylamine derivative or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. In certain compositions, the additional therapeutic agent is a second hydroxylamine derivative or a pharmaceutically acceptable salt thereof.

A production method of an optically active 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine which is useful as an intermediate for synthesizing a pharmaceutical agent is provided and the method comprises the following steps 1) to 4): 1) reacting a bromophenylmorpholine with a hexacyanoferrate(II) or a hydrate thereof at a temperature of from 110° C. to 140° C. in a reaction mixture comprising a Na2CO3, an organophosphorus compound, and a palladium catalyst in a polar aprotic solvent alone or combination of a polar aprotic solvent and other polar aprotic solvent or hydrocarbon solvent to give a cyanophenylmorpholine; 2) reacting the cyanophenylmorpholine with hydroxylamine or hydroxylamine hydrochloride at a temperature of from 10° C. to 40° C. in an aprotic polar solvent to give a hydroxylamine derivative; 3) reacting the hydroxylamine derivative with an acylation reagent selected from the group consisting of aliphatic acyl halides, aromatic acyl halides, aliphatic acyl anhydrides and aromatic anhydrides; and 4) keeping the mixture obtained after step 3) at a temperature of from 60° C. to 140° C. to give a 2-{4-(5-substituted-oxadiazolyl) phenyl}morpholine.

The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and / or preventing various medical dysfunctions and diseases arising from reactive oxygen species (ROS) and / or excess Zn ions, in particular stroke, Parkinson's disease and Alzheimer's disease. The compounds of the invention possess similar or superior LPO inhibition activity to the reference compounds of Trolox and Ebselen. While showing lower toxicity, they also effectively inhibit the cerebral neuronal cell death caused by ROS and / or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.

Described is method for preparing tertiary amines comprising sequential, exhaustive alkylation of a hydroxylamine derivative and cleavage of the O—N bond using the following steps:a) reacting the hydroxylamine derivative with an alkylating agent or with a carbonyl compound to form an oxime intermediate.b) reacting the oxime intermediate with a reducing agent to produce an alkylated derivativec) reacting the alkylated derivative with an alkylating agent or a carbonyl compound in the presence of a reducing agent to produce a dialkylated derivatived) reacting the dialkylated derivative with an alkylating agent to produce a quaternized derivativee) reacting the quaternized derivative with a reagent causing cleavage of the O—N bond to produce a tertiary amine.

The invention concerns hydrous compositions based on polychloroprene and hydroxylamine derivatives, processes for their production and their use as adhesives. The polychloroprene dispersions are stabilized by the addition of hydroxyalkylamine after removal of residual monomer.

The invention provides a synthesis method of polysubstituted isoxazolidine, and relates to the technical field of biological medicines, terminal alkyne, acetophenone and N-alkyl hydroxylamine derivatives are used as reaction raw materials to react in an aprotic polar solvent in the presence of a strong base to obtain an isoxazoline derivative with a plurality of substituent groups, then reduction is performed under the action of sodium cyanoborohydride to obtain a corresponding isoxazolidine derivative with a plurality of substituent groups; the adopted raw materials are cheap, the noble metal catalyst is not needed in the reaction process, and the substrate application range is wide; the product has good stereoselectivity, and various types of (E)-2, 3, 5-trisubstituted isoxazolidine can be obtained.

A color developer solution capable of inhibiting precipitation or tar-staining occurring in the processing tank or the roller rack, even when being processed rapidly or at low replenishing rate and a concentrated composition thereof is disclosed, comprising at least one selected from specified N-disubstituted hydroxylamine derivatives and at least one selected from specified N-monosubstituted hydroxylamine derivatives in a molar ratio falling within the range of 1000:1 to 1:1.

The invention discloses a chemical synthesis method of 3-isoxazolyl benzyl acetate. The chemical synthesis method comprises the following steps: S1, carrying out addition reaction through butene nitrile and bromine gas and generating 3-amino-5-methylisoxazole in the presence of a hydroxylamine derivative; S2, preparing 3-amino-5-methylisoxazole into diazonium salt under low temperature under the action of catalysis, carrying out substitution reaction on the diazonium salt in a hydrochloric acid environment, substituting amino and preparing 3,5-dimethylisooxazole, carrying out demethylation andpreparing 3-chloromethylisoxazole; and S3, adding 3-chloromethylisoxazole and cuprous cyanide into an organic solvent which is dimethyl sulfoxide, reacting and preparing 3-isooxazole acetonitrile. According to the chemical synthesis method of 3-isoxazolyl benzyl acetate, the raw materials are products obtained by directly cracking petroleum; production is carried out by five steps of addition, catalysis, substitution, hydrolysis and esterification; the reaction is rapid; when 3-chloromethylisoxazole as an intermediate is prepared, the yield reaches up to 75%; the production yield is ensured.

The invention provides an etching solution composition for molybdenum-containing metal film and a manufacturing method for array substrate for display using the same, and the etching solution composition for molybdenum-containing metal film contains hydrogen peroxide, fluorine compound, azole compound, hydroxylamine derivative and water in a certain content.

The invention relates to meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors. The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and / or development of a disease or condition. In some embodiments, the diseaseor condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.