126results about "Preparation by N-O/N-N bonds" patented technology

The invention discloses a bifurcate alkyl chain and a preparation and an application thereof in organic conjugated molecules. The bifurcate alkyl chain serving as a solubilization group is applied in preparing organic conjugated molecules (particularly organic conjugated polymers), the interval number m of a formed alkyl side chain and main methylene is larger than one, capable of reducing effects of the alkyl chain on main Pi accumulation, so that the solubility of the organic conjugated molecules is guaranteed, and the mobility ratio of current carriers is improved greatly, the bifurcate alkyl chain is suitable for being used as organic semiconductor materials in photoelectric devices of organic field effect transistors, organic solar cells, organic light emitting diodes and the like.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

The invention discloses a method used for reductive amination using a jet reactor, and belongs to the field of chemical technology. According to the method, the jet reactor is adopted. The jet reactor comprises a reactor, an ejector, a circulating pump, a concentration device, a heat exchanger, and a mixer. The jet reactor is used for chemical product hydrogenation reduction. According to the method, a mixture containing a catalyst, raw materials, and a target amination product is taken as a dynamic fluid, high speed liquid flow is obtained via injection, and stable turbulent flow is formed at a nozzle, and in addition, negative pressure is formed around the nozzle, entrainment of hydrogen is realized, and gas-liquid-solid complete mixing reaction is realized. After reaction, and obtained product is subjected to condensation separation so as to obtain partially aminated products; a concentrate containing the catalyst and a reduced material are subjected to preheating using the heat exchanger, and mixing using the mixer, and then are delivered into the ejector for circular reaction. The method can be used for obtaining amines via reduction of nitro compounds, nitroso compounds, azo-compounds, azoxy compounds, and hydride azo compound.

The invention discloses a novel nucleic acid fluorescence probe. Amido is introduced into tetraphenyl ethylene, amido is a basic group and can be combined with nucleic acid, so that molecular rotation is limited, nonradiative excited-state relaxation is inhibited and fluorescence is obviously enhanced, and thus nucleic acid detection is realized. The novel nucleic acid fluorescence probe has high sensitivity to double-stranded DNA and single-stranded DNA, and the probe has good application prospect to gel electrophoresis or detection of nucleic acid in biological samples.

It is an object of the invention to provide a novel fungicide which exhibits a wide controlling spectrum against pathogens of various crops, and solves the toleration problem. The diamine derivative represented by the formula (1) and a process for preparation of the same, fungicides comprising the same as an active ingredient are disclosed: [wherein R1 is substituents such as an alkyl group having 1 to 6 carbon atoms and the like, R2 and R5 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, R3 and R4 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, or R3 and R4 may be bonded to each other to form a hydrocarbon ring having 3 to 6 carbon atoms, R6, R7, R8 and R9 are each independently substituents such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, R10 is a substituent such as hydrogen atom, an alkyl group having 1 to 6 carbon atoms and the like, A is an oxygen atom or a sulfur atom, and Q is an aryl group or a heterocycle].

The invention discloses a catalyst for reductive amination of isophorone nitrile to synthesize isophorone diamine. The catalyst comprises an active component and a carrier. The active component is cobalt, the carrier is active carbon, and cobalt has a fcc crystal form when being loaded on active carbon. The disclosed novel catalyst has the advantages of little using amount, high catalytic activity, good stability, and resistance to inactivation and is capable of efficiently catalyzing the reductive amination of isophorone nitrile to synthesize isophorone diamine without a hydrogen reduction technology.

The invention relates to a preparation method of 2,5-dimethyl-1,4-phenylenediamine. The method is characterized in that aniline substances are used as a raw material and are made into 2,5-dimethyl-1,4-phenylenediamine through a diazotization reaction, a coupled reaction, a hydrogenolysis reaction and purification treatment. According to the invention, the main and the auxiliary raw materials are cheap and easy to obtain, the reaction steps are relatively few, the yield is high, the operation is simple and convenient, and the method is used for further replacing the old technology to realize and develop the novel industrialized production of the product; the aniline substances are reclaimed to be still used as auxiliary raw materials for preparing aniline diazonium salt, so that cost and pollution are reduced, circular economy is produced, and cleaner production is realized; the quality of the obtained product is improved greatly, and the content is far more than the old product, especially an exported product of the content of 75%; the prepared product can not only be used for dye and paints, but also can expand using functions of a high-performance material monomer.

The invention relates to a preparation method for 5-chloro-2-methyl-1,4-phenylenediamine. 5-chloro-2-methyl aniline is used as a raw material and subjected to coupled reaction with aniline diazonium salt prepared through diazotization of an aniline substance to prepare an azo-compound; the azo-compound is subjected to hydrazine hydrate normal-pressure reduction and hydrogenolysis with the existence of a catalyst; in the later period of reduction, after the aniline substance taken off by reaction is subjected to water steaming out while reduction is performed; a methanol lysate is added to remove the catalyst so as to obtain a methanol water solution of 5-chloro-2-methyl-1,4-phenylenediamine; the obtained methanol water solution is subjected to adsorption, decoloring and edulcoration, and then after-treatment technologies of cooling crystallization, filtering, water washing, drying and the like to prepare high-purity 5-chloro-2-methyl-1,4-phenylenediamine; a mixture of the aniline substance subjected to steam distillation and recovery and water is separated and rectified, and then recycled in preparation of aniline diazonium salt. The preparation method has the characteristics of novel route, easily accessible raw material, high atom utilization ratio, conventional equipment, simple and convenient operation, little pollution, capability of realizing circular economy and the like.

The invention relates to hexahydropentaleno derivatives, the preparation method and use in medicine thereof, and in particular to hexahydropentaleno derivatives or stereo-isomers or pharmaceutically acceptable salts thereof as shown in general formula (I), and to the preparation method therefor and pharmaceutical compositions comprising the derivatives, and to the use thereof as a therapeutical agent, especially as a DPP-IV inhibitor. The definition of each substituent in formula (I) is the same as the definition in the description.

The invention relates to a synthesis method of p-phenylenediamine, and belongs to the technical field of organic material preparation. Aniline adopted as a raw material undergoes a diazotization reaction and a heating rearrangement reaction to generate 4-aminoazobenzene, a proper amount of an acid is added, and the 4-aminoazobenzene is separated out; the 4-aminoazobenzene is dissolved in a propersolvent, a catalyst is added, the p-phenylenediamine product is obtained through a hydrogenation reduction reaction, filtration and reduced pressure distillation, and aniline is recovered as a byproduct and can be recycled as the raw material. Compared with an existing p-phenylenediamine production method, the method of the invention has the advantages of safe and environmentally-friendly preparation process, little emission of three wastes, easily available reaction raw materials, simple reaction steps, and high purity of the finally prepared product, so the method has good industrial implementation prospects.

The process of synthesizing cyclohexylamine includes the reduction reaction of butanone oxime and hydrogen inside solvent with ammonia at pressure of 1-5 MPa and temperature of 20-150 deg.c in the presence of Raney Ni catalyst; and the dewatering, drying and rectification of the reaction product. The Raney Ni catalyst amount is 0.3-10 wt% of butanone oxime, and the weight ratio between ammonia and butanone oxime is 0-1 to 1. The cyclohexylamine synthesizing process has low cost and high yield.

The present invention provides novel anthracene derivatives. In particular, the present invention provides light-emitting elements with high luminous efficiency, and light-emitting elements with long lifetime. Further, the present invention provides light-emitting devices and electronic devices having long lifetime by using these light-emitting elements. An anthracene derivative represented by the general formula (1) is provided. In addition, since the anthracene derivative represented by the general formula (1) has high luminous efficiency, a light-emitting element using the anthracene derivative represented by the general formula (1) can also have high luminous efficiency. By using the anthracene derivative represented by the general formula (1), light-emitting elements with long lifetime can be provided.

The present invention relates to a polymer supported reagent comprising a novel crosslinked mesoporous polymer, enabling a simple and easy production of an azoxy compound or an azo compound from an aromatic nitro compound, and a method of selectively reducing an aromatic nitro compound by using the same. The polymer supported reagent comprises a certain acrylamide mesoporous crosslinked polymer.

Process for making both ACN and HMD from partial hydrogenation of ADN by using a combination of distillations resulting in the formation of a mixture of HMD and THA that can be hydrogenated to produce a mixture of HMD and HMI that can be separated easily by simple distillation.