130 results about "PAMAM dendrimer" patented technology

The invention relates to the technical field of detection sensors and particularly relates to an electrochemical aptamer electrode for kanamycin detection. Graphene-polyaniline compound, polyamide-amine dendritic high molecule-gold nano compound, kanamycin anti-body are modified on a glass carbon electrode in sequence from bottom to up; the surface of the electrode is sealed with BSA (Bovine Serum Albumin) and single chain DNA (Deoxyribose Nucleic Acid) containing 10 adenine nucleotide. The preparation method is simple, stable in performance and good in electrode repeating performance and is suitable for practical applications of kanamycin detection in food safety and bio-sensor industrialization; the prepared electrode is low in technical cost and is suitable for the requirement of low cost in industrialization; according to a sandwich type electrochemical sensing system fixed by using the glass carbon electrode as a fixing carrier and based on a DNA aptamer, rapid and online kanamycin detection in food is realized and the detection limit is 4.6x10<-6>mu gmL<-1>.

Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II): wherein A comprises at least one acetal group; B is selected from the group consisting of —CH—, —CH(CH3)—, CH2CH—, —CH2C(CH3)—, —CH(CH3)CH—, and —CHCH(CH3)CH(CH3)—; Z is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl; D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and G is selected from the group consisting of C4 to C20 alkyl, C6-C10 aryl, and —(OCH2CH2)n—, where n is in the range of 1 to about 250, are useful in nucleic acid delivery applications. In preferred embodiments, complexes formed between polyacetals of the formulae (I) or (II) and polynucleotides are useful as transfection reagents.

A process for forming a conjugate of a polyoxyalkylene polymer, such as polyethylene glycol, with a compound containing an amine group(s) and / or a sulfide group(s) by reacting the compound with an acrylate terminated polyoxyalkylene, such as polyethylene glycol terminated at one end with acrylate or methacrylate and terminated at the other end With a methoxy group. The reaction is believed to be a Michael addition. When the compound contains primary amine groups, such as the surface primary amine groups of a PAMAM dendrimer, it is usually desirable to convert the primary amine groups to secondary amine groups before the reaction with the acrylate terminated polyoxyalkylene.