57 results about "Pamam dendrimers" patented technology

The invention discloses injectable hydrogels which are in the form of crosslinked nano beads or particle in the size range 5 nm to 10 μm, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents and their methods of preparation. The said gel is formed by reaction of the PAMAM dendrimer with asymmetrical end groups with other polymer wherein the other polymer is selected from the group of linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel disclosed in the present invention is formed as small crosslinked particles in the size range 25 nm to 10 μm and is suitable for injectable delivery of hydrogel to any of the body orifices, tissues by intramuscular or subcutaneous route and ocular delivery for the purpose of therapeutic treatment and imaging.

A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.

A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.

The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and / or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and / or targeting agents (e.g., in disease diagnosis and / or therapy, etc.))).

The invention relates to application of polyamide-amine (PAMAM) dendrimer coated ZnX (X=S, Se, Te) semiconductor quantum dots in fingerprint development, belonging to the technical field of material preparation. The method comprises the following steps: synthesizing a PAMAM dendrimer coated ZnX semiconductor quantum dot solution; and carrying out fluorescence labeling on latent fingerprints by using the PAMAM dendrimer coated ZnX semiconductor quantum dot solution. The method provided by the invention avoids the problem of toxicity of heavy metal ion Cd<2+> in the existing developing reagent, and the PAMAM dendrimer coated ZnX semiconductor quantum dots are harmless to the environment and users; the addition of the metal ion M<2+> can further enhance the fluorescence-emission strength of the ZnX semiconductor quantum dots; and by using the interaction between the PAMAM dendrimer and the fingerprint residue, the invention reserves the high development efficiency in the physical development method, and overcomes the defect of insufficient detailed development of fingerprint lines in the physical development method, thereby enhancing the precision and accuracy of the latent fingerprint development.

The invention provides for compositions for transdermal delivery of a therapeutic agent associated with a surface modified poly(amidoamine) PAMAM dendrimer, wherein the surface modified dendrimer increased skin penetration of the therapeutic agent. The invention particularly provides for compositions and methods for transdermal delivery of anticancer and chemo-preventive agents.

The invention relates to a method for preparing a PAMAM dendrimer-modified gold nanorod composite carrier, belonging to the field of nanocomposite materials. In the method, gold ions are firstly reduced into gold nanoseeds through the chemical reduction method in the presence of a coating agent, and the seeds are added into the growth solution of the gold ions for preparing gold nanorods, wherein, the growth solution contains the gold ions, a weak reducing agent and a surfactant; amino-PAMAM dendrimers of any generation are reacted with methyl mercaptoacetate, and mercapto-PAMAM dendrimers are obtained; finally, a hybrid reaction is carried out on the gold nanorods and the mercapto-PAMAM dendrimers, and PAMAM dendrimer-modified gold nanorod composite carrier is obtained. In the composite carrier, the PAMAM dendrimers are evenly coated on the surface of each gold nanorod in the composite carrier, and the maximum absorption peak of the composite carrier is about 542nm and 871nm.

The invention relates to a method for preparing a superparamagnetic nanoparticle photocatalyst with a Fe3O4-PAMAM-TiO2 core-shell structure by using polyamide-amine (PAMAM) dendrimer as a template and an isolation layer in a low-temperature aqueous solution. The method is characterized by comprising the following steps: firstly, with the PAMAM dendrimer as the template, preparing a superparamagnetic Fe3O4-PAMAM nanoparticle colloidal solution by using a co-precipitation method; then adding the PAMAM dendrimer with different terminal groups and coating Fe3O4-PAMAM nanoparticles so as to form a dendrimer isolation layer; finally, dropwise adding a TiCl4 absolute ethanol solution, and carrying out normal pressure reaction and hydrothermal reaction so as to obtain the nanoparticles with the Fe3O4-PAMAM-TiO2 core-shell structure and a complete TiO2 shell layer; and carrying out washing and redispersion so as to obtain the nanoparticle photocatalyst with the Fe3O4-PAMAM-TiO2 core-shell structure.

The invention provides a preparation method of a ZnO / graphene oxide composite photocatalysis material. The ZnO / graphene oxide composite photocatalysis material is a ZnO / PAMAM / graphene oxide composite material. The preparation method of the ZnO / graphene oxide composite photocatalysis material comprises the following steps: introducing amino groups to the surface of graphene oxide, forming PAMAM dendrimers on the surface of graphene oxide through using a Michael addition reaction of methyl acrylate and ethylene diamine, and forming ZnO on the surface of the PAMA dendrimer modified graphene oxide in an in situ manner by using the coordination between Zn<2+> and tertiary amino groups and amido groups on the PAMAM and hydroxyl groups and carboxyl groups on the surface of graphene oxide. The composite material prepared in the invention has excellent adsorption performance and photocatalytic activity on common organic pollutants.

The present invention relates to a method for preparing superparamagnetic Fe3O4-PAMAM-ZnO / TiO2 nanoparticles with a core-shell composite structure by using a polyamide-amine (PAMAM) dendrimer as a template and a spacer layer in a low temperature aqueous solution. The method is characterized by comprising the following steps: first preparing a superparamagnetic Fe3O4-PAMAM nanoparticle colloidal solution by using a PAMAM dendrimer as a template, then adding a right amount of PAMAM dendrimer to wrap the Fe3O4-PAMAM nanoparticles, under alkaline condition adding a solution of soluble zinc salt and a titanium tetrachloride solution at the same time; conducting atmospheric reaction and a hydrothermal reaction to obtain the superparamagnetic Fe3O4-PAMAM-ZnO / TiO2 nanoparticles with core-shell composite structure and with a complete ZnO / TiO2 composite shell layer. The particles can be dispersed in the form of individual particle in solution, and has high photocatalytic activity and magnetic recovery rate.

The present invention discloses new types of poly(amidoamine) (PAMAM) dendrimer-cross-linked polyimide membranes and methods for making and using these membranes. The membranes are prepared by cross-linking of asymmetric aromatic polyimide membranes using a PAMAM dendrimer as the cross-linking agent. The PAMAM-cross-linked polyimide membranes showed significantly improved selectivities for CO2 / CH4 compared to a comparable uncrosslinked polyimide membrane. For example, PAMAM 0.0 dendrimer-cross-linked asymmetric flat sheet poly(3,3′,4,4′-diphenylsulfone tetracarboxylic dianhydride-3,3′,5,5′-tetramethyl-4,4′-methylene dianiline) (DSDA-TMMDA) polyimide membrane showed CO2 permeance of 135.2 A.U. and CO2 / CH4 selectivity of 20.3. However, the un-cross-linked DSDA-TMMDA asymmetric flat sheet membrane showed much lower CO2 / CH4 selectivity (16.5) and higher CO2 permeance (230.8 GPU).

A process for forming a conjugate of a polyoxyalkylene polymer, such as polyethylene glycol, with a compound containing an amine group(s) and / or a sulfide group(s) by reacting the compound with an acrylate terminated polyoxyalkylene, such as polyethylene glycol terminated at one end with acrylate or methacrylate and terminated at the other end With a methoxy group. The reaction is believed to be a Michael addition. When the compound contains primary amine groups, such as the surface primary amine groups of a PAMAM dendrimer, it is usually desirable to convert the primary amine groups to secondary amine groups before the reaction with the acrylate terminated polyoxyalkylene.

The invention belongs to the technical field of biological pharmacy and particularly relates to preparation of a nano-drug delivery system loaded with classical ''abstinence drug'' disulfiram and photosensitizer indocyanine green based on a low-generation PAMAM (polyamide-amine) dendrimer and application of the nano-drug delivery system in the anti-tumor field. According to the invention, disulfiram DSF and indocyanine ICG are entrapped into low-generation dendrimer PAMAM-G0 by virtue of a solvent cross-linking method, so as to obtain the nano-drug delivery system. The prepared nano-drug delivery system is gathered at a tumor site through an EPR effect and can simultaneously play roles of chemotherapy and photodynamics therapy, so that the tissue toxicity of chemotherapeutic drugs and thephototoxicity of the photodynamics therapy are reduced, and a new research direction is provided for the anticancer treatment of disulfiram.

The invention discloses a modified PAMAM (polyamide-amine) dendrimer based double-crosslinked in-situ gel and a preparation method thereof. The gel consists of the following components in percentage by weight: 2-10% of glucan aldehyde, 5-15% of thiol PAMAM and the balance of water. A preparation process comprises the following steps: preparing a thiol modified PAMAM dendrimer; preparing a thiol modified PAMAM dendrimer solution; preparing a glucan aldehyde solution; and mixing the thiol modified PAMAM dendrimer solution and the glucan aldehyde solution to prepare the double-crosslinked in-situ gel. The dendrimer in the gel disclosed by the invention has the advantages of highly-intensive active crosslinking groups and controllable surface functional group density, and is used for constructing the gel by virtue of in-situ crosslinking of strong and weak chemical bonds to ensure that the gel shows relatively high storage modulus and strength. Moreover, the preparation method disclosed by the invention does not need any small-molecular additives and illumination operations, is simple, convenient and feasible, is good in biocompatibility, and can be applied to the fields of biological adhesion, tissue engineering and the like.

A dendrimer formulation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of necrotizing enterocolitis.

The invention discloses a PAMAM dendrimer supported Schiff base compound as well as a preparation method and an application thereof. According to the preparation method, ethylenediamine is taken as a kernel, a Micheal addition reaction and an amidation of ester between the ethylenediamine and methyl acrylate are performed repeatedly to obtain a branch, and a Schiff base compound is grafted on the tail end of branch to obtain the PAMAM dendrimer supported Schiff base compound. The prepared PAMAM dendrimer supported Schiff base compound has the characteristics of large adsorption quantity and high adsorption capacity for heavy metal in smoke, the effect of reduction of the release amount of the heavy metal in main stream smoke of cigarettes can be effectively realized if a few compounds are added to cigarette filter sticks, and the compound is simple in preparation process and suitable for industrial production.

The invention relates to a method for preparing paramagnetic Fe3O4-PAMAM-ZnO-TiO2 core-shell-shell-structured nanoparticles by taking polyamide-amine(PAMAM) dendrimers as a template and a separation layer in a low-temperature aqueous solution. The method is characterized in that firstly, the PAMAM dendrimers are firstly taken as the template, and a paramagnetic Fe3O4-PAMAM nanoparticle colloidal solution is prepared by adopting a coprecipitation method; secondly, the PAMAM dendrimers are added to wrap Fe3O4-PAMAM nanoparticles; thirdly, under the alkaline condition, soluble zinc salt is added to generate a ZnO shell layer; fourthly, a titanium tetrachloride solution is added to generate a TiO2 shell layer, and then the paramagnetic Fe3O4-PAMAM-ZnO-TiO2 core-shell-shell-structured nanoparticles with the complete ZnO shell layer and TiO2 shell layer are prepared. The nanoparticles can be dispersed into a solution in a single particle mode and have the higher photocatalytic activity and magnetic recovery rate.

The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).

The invention discloses a PLA / CA / PAMAM dendrimer blend and a preparation method thereof. According to the preparation method, PLA, CA and PAMAM dendrimers are subjected to solution blending so as to obtain the PLA / CA / PAMAM dendrimer blend. A preparation method of the PAMAM dendrimers comprises the following steps: carrying out an addition reaction on ethylenediamine and methyl acrylate to obtain ester group-terminated G-0.5 PAMAM dendrimers; carrying out an amidation reaction on the G-0.5 PAMAM dendrimer and ethanediamine to obtain G-1.0 PAMAM dendrimers which are terminated by amino groups; and repeating the addition reaction and the amidation reaction to synthesize the PAMAM dendrimers with different end group types and different generations. According to the invention, the PAMAM dendrimers are adopted for compatibilization modification of the compatibility of PLA and CA, the compatibility of the prepared PLA / CA / PAMAM dendrimer blend is better, and the strength and toughness of the prepared PLA / CA / PAMAM dendrimer blend are also improved.

The invention discloses a ligand exchange method of quantum dots and a quantum dot compound, and the ligand exchange method of the quantum dots comprises the following steps: providing a first PAMAM dendrimer; converting an amino group in the first PAMAM dendrimer into a functional group containing a sulfydryl group to obtain a second PAMAM dendrimer; and mixing the second PAMAM dendrimer with oil-phase quantum dots in a non-polar solvent for ligand exchange to obtain the quantum dots. The second PAMAM dendrimer is combined to the surface of the quantum dots through ligand exchange reaction, and the stability and solubility of the quantum dots can be improved at the same time.

The invention discloses a preparation method of a quantum dot, and the preparation method of the quantum dots comprises the following steps: providing a composite material which comprises a PAMAM dendrimer and metal ions combined in a cavity of the PAMAM dendrimer; carrying out modification treatment on a PAMAM dendrimer end functional group in the composite material to convert an amino group in the PAMAM dendrimer into an oil-soluble group so as to obtain an oil-soluble composite material; and adding the oil-soluble composite material into a quantum dot growth reaction system, and mixing to obtain the quantum dots. According to the method, the metal ions can be uniformly doped into the quantum dots, the quantum dots which are not subjected to lattice dislocation and are good in quality are prepared, and the uniform doping of the metal ions can effectively improve the energy level width of the quantum dots so as to change the absorption spectrum and the luminescence spectrum of the quantum dots.

The present disclosure relates to a dendrimer-based conjugate of the formula Vm-D-C-D′-(T-F)n, which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.

The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and / or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and / or targeting agents (e.g., in disease diagnosis and / or therapy, etc.))).

The invention provides a magnetic PAMAM dendrimer material modified by p-mercaptobenzoic acid. The preparation method of the material comprises the following steps: preparing amino-modified magnetic nanoparticles, carrying out n-generation PAMAM grafting on the amino-modified magnetic nanoparticles, and modifying the grafted product with p-mercaptobenzoic acid to obtain the p-mercaptobenzoic acid-modified magnetic PAMAM dendritic polymer material. The 4-MBA modified magnetic PAMAM dendritic polymer material is obtained by modifying a magnetic PAMAM dendritic polymer with p-mercaptobenzoic acid, and the material can realize simple, rapid, sensitive and effective determination of polycyclic aromatic hydrocarbons (PAHs) in an environmental water sample. The material used as a solid phase adsorbent has better linearity within the range of 0.1-300mu g / L, and the detection limit range is 0.014-0.055 mu g / L. Compared with other conventional methods, the method has the advantages of simplicity, durability, easiness in separation and high enrichment efficiency.

The invention relates to a preparation method of a magnetic Fe3O4 loaded functionalized PAMAM dendrimer adsorbent. The preparation method comprises the steps: taking 3-aminopropyltriethoxysilane as acentral core, and firstly, preparing a 2.0-generation triethoxy silicon-based PAMAM dendrimer; then carrying out surface modification on silicon dioxide coated magnetic nano Fe3O4 by utilizing the 2.0-generation triethoxy silicon-based PAMAM dendrimer; and finally functionalizing amino at the tail end of the PAMAM dendrimer by salicylaldehyde to prepare the metal ion adsorbent. The adsorbent prepared by the method has magnetism, contains rich nitrogen and oxygen functional groups, is easy to recycle, has good adsorption performance and adsorption selectivity on Hg (II) in water, and can be used for selective adsorption separation and enrichment recovery of Hg (II).

The invention discloses a high-dispersity polyimide / nanoparticle composite thin film and a preparation method thereof. The preparation method comprises: uniformly mixing quantitative nanoparticles with a PAMAM (Polyamidoamine) dendrimer to obtain a mixed solution I; uniformly mixing an anhydride terminated polyamide acid solution with the mixed solution I and reacting to obtain a mixed solution II; carrying out film formation on the mixed solution II to obtain a polyamide acid gel film; furthermore, carrying out heating treatment on the polyamide acid gel film to cyclize polyamide acid into polyimide, so as to obtain the polyimide / nanoparticle composite thin film. By utilizing the preparation method provided by the invention, the nanoparticles are uniformly dispersed in a polyimide matrix. Furthermore, a tail end of the PAMAM dendrimer is connected with the polyamide acid through a chemical bond; the prepared polyimide / nanoparticle composite material has relatively good high temperature resistance and low temperature resistance, excellent mechanical properties and good chemical stability.

The invention discloses a quantum dot light emitting diode and a preparation method thereof, wherein the quantum dot light emitting diode comprises a cathode, an anode and a quantum dot light emitting layer arranged between the cathode and the anode, and the quantum dot light emitting layer is made of materials. It is a mixed material composed of quantum dots and oil-soluble PAMAM dendrimers, and the exciton Bohr radius of the quantum dots is larger than the diameter of the quantum dots. In the present invention, the spatial distance between the quantum dots in the quantum dot light-emitting layer will be effectively pulled apart by the oil-soluble PAMAM dendrimers, thereby effectively reducing the energy transfer between the quantum dots, and indirectly improving the The fluorescence intensity of the quantum dot light-emitting layer; in addition, the oil-soluble PAMAM dendrimer can be wrapped on the surface of the quantum dot to bind the excitons, thereby improving the quantum yield of the quantum dot light-emitting layer, thereby improving the quantum dot light-emitting diode. Luminous efficiency.

The invention discloses a quantum dot light-emitting diode and a preparation method thereof, wherein the quantum dot light-emitting diode comprises a cathode, an anode and a quantum dot light-emitting layer arranged between the cathode and the anode, and is characterized in that the anode and the anode A first refraction layer is arranged between the quantum dot luminescent layer, a second refraction layer is arranged between the cathode and the quantum dot luminescent layer, and the material of the first refraction layer is a first PAMAM dendrimer, and the The second refraction layer material is a composite material, and the composite material includes a second PAMAM dendrimer and metal atom clusters combined in the cavity of the second PAMAM dendrimer, and the algebra of the first PAMAM dendrimer is less than The algebra of the second PAMAM dendrimer. The present invention can effectively improve the light extraction efficiency and stability of the quantum dot light-emitting diode by arranging the first refraction layer between the anode and the quantum dot light-emitting layer, and the second refraction layer between the cathode and the quantum dot light-emitting layer .

The invention discloses a quantum dot color film and a preparation method thereof, and the material of the quantum dot color film comprises a PAMAM dendrimer and oil phase quantum dots combined in thecavity of the PAMAM dendrimer. In the quantum dot color film provided by the invention, the PAMAM dendrimer can realize coating and dispersion of the oil phase quantum dots, so that the oil phase quantum dots can effectively isolate water and oxygen, and the quantum dot color film can maintain stable performance.

The invention discloses a catalyst for producing succinic anhydride by hydrogenation of maleic anhydride and a preparation method thereof. The catalyst is prepared by adopting dendritic supramolecular polyamide-amine PAMAM dispersion and wet reduction method with a nanometer iron content of 0.1-15wt %, the carrier is a loaded nano-iron catalyst of PHTS or Al-PHTS. The preparation method is as follows: impregnating PHTS or Al-PHTS carrier with an impregnating liquid prepared by supramolecular dendrimer PAMAM and active metal iron salt, and obtaining it after borohydride wet reduction and vacuum drying. The catalyst catalyzes the hydrogenation of maleic anhydride to prepare succinic anhydride, the conversion rate of maleic anhydride is greater than 90.5 percent, and the selectivity of succinic anhydride is greater than 99.0 percent. The catalyst has the advantages of high activity, good selectivity, low cost and environmental friendliness.