411 results about "Nano carriers" patented technology

The invention discloses an insertable medical device for delivering one or more pro-healing agents to a site of deployment of a stent in a blood vessel. The surface of the insertable medical device is coated with nano-carriers that include the one or more pro-healing agents encapsulated with one or more biological agents. The nano-carriers are released when the insertable medical device is expanded at the site. The nano-carriers thus released penetrate tissues at the site resulting in dissolution of the one or more biological agents. Thereafter, the one or more pro-healing agents are released from the nano-carriers at the site. Thus, an in-tissue release of the one or more pro-healing agents at the site is achieved thereby improving endothealisation, extracellular matrix formation and healing at the site post deployment of the stent in the blood vessel.

Disclosed is a surfacely modified hydrophobic Chitosan oligosaccharide polymer drug-loaded colloidal cluster, obtained by grafting chitosan with a average molecular weight of 1.5kD-51kD and aliphatic acid of C10-C22, comprising based on hydrophobic modified Chitosan oligosaccharide polimer colloidal clusters, modifying amidogens or hydroxy groups of Chitosan oligosaccharide molecules on polimer surface with bi-functional small organic moleculers, forming chemical bond bridges between molecules on the surfaces of polymer colloidal clusters,to improve the instability of polymer colloidal cluster diluted, and to imorove the original loose structure of polimer colloidal cluster surfece to form a fine and close net-shaped structure, to decrease a sudden release of drugs, and to control drugs with slow release. The drug-loaded colloidal cluster provided is a nano-carrier with excellent organelle targeting, is applicated in life science field and pharmacy field.

The invention provides a catalyst with high catalytic activity, selectivity and stability, namely supported imidazole ion liquid cross-linked polymer nano particles, and belongs to the technical field of chemical synthesis. Experiments prove that the catalyst for the reaction of carbon dioxide and epoxy compound for generating a five-member ring compound has high selectivity (100 percent) and conversion rate (99.8 percent) and can be reclaimed and reused. In addition, a preparation method for the catalyst is simple and has mild reaction conditions, the catalyst is easily separated from a product by using a filter method, and any stabilizer or surfactant is not added in the synthesis process. The catalyst is suitable for large-scale production, and has wide application prospect in the fields of polymer nano carriers, industrial catalysis and the like.

The invention belongs to the field of immobilization of proteins, and relates to preparation and application of a dopamine functional magnetic nano-carrier. The preparation comprises the following steps: firstly, dissolving FeSO4.4H2O and FeCl3.6H2O into distilled water, high-speed stirring and under protection of nitrogen, adding ammonia water of 25% NH4OH, and adding oleic acid; secondly, repeatedly cleaning black precipitates obtained by a stirring reaction and then using a strong magnet to perform precipitation separation, and drying to obtain oleic acid magnetic nano-particles; and finally, adding the oleic acid magnetic nano-particles into a dopamine hydrochloric acid solution, after the reaction is over, using a magnet to separate, cleaning and drying obtained deep brown precipitates, and then the dopamine functional magnetic nano-carrier can be obtained. According to the preparation and application of the dopamine functional magnetic nano-carrier provided by the invention, dopamine hydrochloride is adopted for modifying magnetic oleic acid nano-particles, so that the surface of a magnetic nano-particle has a plentiful of quinonyls and amidogen functional groups, thus proteins can be effectively immobilized; besides, the surface of the carrier has a layer of soft poly dopamine oxide films, the surface area is larger, and the preparation method is simple.

The invention discloses drug-carrying liposome co-modified by folic acid and TAT peptide and a preparation method thereof. The drug-carrying liposome comprises liposome, a long chain targeted membrane material, a short chain targeted membrane material and a drug. Meanwhile, the invention provides the preparation method of the drug-carrying liposome co-modified by folic acid and TAT peptide. The method comprises the following steps: weighing phospholipid, cholesterol, the long chain targeted membrane material, the short chain targeted membrane material and the drug, dissolving the components in an organic solvent, and then carrying out rotary evaporation at 50 DEG C under reduced pressure to remove the organic solvent so as to obtain a medicated liposome membrane; adding a phosphate buffer solution into the medicated liposome membrane for dissolving, carrying out ultrasonic treatment for 2 minutes, and filtering for 10 times by using a 0.22mu m membrane to obtain double-target drug-carrying liposome. According to the drug-carrying liposome disclosed by the invention, the TAT peptide is connected with specific ligands by means of PEG with different weight-average molecular weights to establish a nanometer carrier modified by double ligands, and the prepared drug-carrying liposome can be used for efficiently conveying the drug in tumor cells.

The invention relates to a heptamethine cyanine active fluorescent probe and a preparation method and application thereof. The structural formula of the heptamethine cyanine active fluorescent probe is as shown in the specification, wherein X=II-IX; each of R1 and R2 is (CH2)mCH3, (CH2)nOH, (CH2CH2O)pCH3 and CH2C6H5; each of R3 and R4 is H, SO3H, SO3Na and SO3K; each of a, b, c, d, e, f and g is 2-8; each of n, m and p is 1-10. The heptamethine cyanine active fluorescent probe has the advantages that the heptamethine cyanine active fluorescent probe is based on near-infrared long-wave heptamethine cyanine dye, indoline is selected as the aroma parent nucleus to increase fluorescence intensity, and methenyl chain intermediate cyclohexene rigid bridging enhances stability; nitrogen derivatives with chemical reactivity sites are used to perform nucleophilic substitution on the meso-position of the heptamethine cyanine parent dye, and accordingly Stokes shift and active chemical groups areincreased greatly to facilitate the fluorescent labeling of various substances; the fluorescent probe is of a symmetrical structure, preparation and purification processes are simplified, and cost islowered favorably; the probe can be used as the fluorescent labeling probe of biological molecules such as high-sensitivity protein, sugar and DNA and nano carriers to perform cell or living-body horizontal fluorescence imaging, and the like.

The invention relates to the fields of macromolecular chemistry and medicinal adjuvant, in particular to an amphoteric ion-based charge reversal chitosan derivative and application thereof in a medicament. The chitosan derivative is characterized in that chitosan is used as a framework, and 2-NH2 of the chitosan is grafted with hydrophilic succinyl group, histidine and hydrophobic long-chain octyl; or 2-NH2 of the chitosan is grafted with hydrophilic lysine and hydrophobic chain octyl, and then succinyl group or citryl playing a role in charge reversal is introduced into the 2-NH2 of the chitosan and the -NH2 of the lysine. The chitosan derivative of the invention has the effect of solubilizing insoluble medicaments; and the surface of the charge reversal chitosan derivative carries negative charges in long circulation in vivo, and the charges are reversed to form positive charges by responding to the weak acid environment condition after reaching the outside of tumor cells or the inside of lysosome, so the chitosan derivative can promote the cells to take in nano carriers and promote escape from the lysosome, improve the delivery efficiency of the medicament and reduce the toxic or side effect of the medicament.

The invention relates to an amphiphilic triblock copolymer, a polymer nano-carrier preparation and preparation methods. The copolymer is a liner polymer compound containing a polyethylene glycol derivative, poly-lysine and poly-leucine, wherein one end of the poly-lysine is connected with the polyethylene glycol derivative through an amide bond, and the other end of the poly-lysine is connected with the poly-leucine through a peptide bond. The amphiphilic triblock copolymer, namely the polyethylene glycol derivative-poly-lysine-poly-leucine triblock copolymer combines the advantages of polyethylene glycol and poly-amino acid, can form a nano-carrier with a three-layer structure by self-assembly in a water solution, and can simultaneously effectively load a small molecular hydrophobic medicament, gene substances and proteins or polypeptides to form a multifunctional nano-carrier.

The invention belongs to the field of enzyme immobilizing, and specifically relates to a method for immobilizing enzymes by using a magnetic ionic liquid composite material. According to the invention, the method comprises the steps that: (1) magnetic nano-particles are prepared; (2) ionic liquid is loaded in the magnetic nano-particles, such that the magnetic ionic liquid composite material is obtained; (3) enzymes are immobilized by using the magnetic ionic liquid composite material. According to the invention, the ionic liquid is loaded in the magnetic nano-carriers, such that a magnetic ionic liquid composite material enzyme immobilizing system is formed. With the method, an ionic liquid microenvironment is introduced, and the ionic liquid has almost no vapor pressure, such that the method has environmental protecting characteristic and designability. With the method, enzyme activity and stability can be improved. According to the invention, a nano-material is used as a carrier in enzyme immobilizing, such that the dispersibility of a catalyst can be improved.

The invention relates to a nano-carrier loaded with a rhodiola rosea extract. The nano-carrier comprises the following components according to the weight ratio: 0.5% to 3% of rhodiola rosea extract, 20% to 30% of solvent, 40% to 50% of emulsifier and 18% to 35% of lipid material; the lipid material is a solid and liquid mixture of a liquid lipid material and a solid lipid material, and the emulsifier comprises a water-in-oil emulsifier and an oil-in-water emulsifier. A preparation method of the nano-carrier with the rhodiola rosea extract comprises the following steps: mixing the lipid material and the emulsifier as an oil phase; adding the water-in-oil emulsifier into the solvent as an internal aqueous phase; adding internal aqueous water into a liquid state oil phase; uniformly mixing and solidifying after being cooled to room temperature; adding the water-in-oil emulsifier, uniformly mixing to obtain a lipid system, solidifying after being cooled to room temperature to obtain the nano-carrier loaded with the rhodiola rosea extract. The invention has the following advantages: the nano-carrier loaded with the rhodiola rosea extract is jointly utilized with a technology of multiple emulsion and lipid nanoparticles, the traditional liquid state oil is replaced by the mixture of the solid state oil and the liquid state oil, the internal aqueous phase as the rhodiola rosea extract is more stable than the traditional multiple emulsion, and the obtained nano-carrier loaded with the rhodiola rosea extract as a material can be added into the cosmetics and foods, so that the existing application defects are effectively solved.

The invention belongs to the technical fields of preparation and applications of nano-carriers, and in particular discloses a preparation method and an application of a multifunctional membrane-controlled targeting nano-carrier integrating tracing and targeted drug delivery effects. With nano mesoporous silica (MSN) as a drug 'warehouse', a positively charged high molecular material and a negatively charged high molecular material as preparation materials of a gating membrane, and adriamycin (DOX), cis-platinum, imatinib, taxol and the like as model anti-cancer drugs, research contents mainlyinclude optimization and improvement of natural materials, construction and process optimization of the gating membrane, structural characterization of a nano complex, drug release kinetic characteristics of drug molecules under the control of the gating membrane, and the like. Meanwhile, in the combination with the tracing imaging function of a fluorescent quantum dot, drug delivery behaviors andanti-tumor effectiveness of the membrane-controlled nano drug delivery system undergo preliminary evaluation through in-vitro experiments. Based upon research results, references are provided for thedesign and preparation of the novel membrane-controlled nano drug delivery system.

The invention provides a bionic binary cooperative nano-carrier as well as a preparation method and an application thereof. The bionic binary cooperative nano-carrier comprises an erythrocyte membrane, glucose oxidase, iron-supporting ferritin nano-particles and a photosensitizer, wherein the glucose oxidase and the iron-supporting ferritin nano-particles are coated with the erythrocyte membrane,and the photosensitizer is embedded into the surface of the erythrocyte membrane or entrapped by the erythrocyte membrane. Chain stimulative responsibility coordination of tumor hunger therapy and chemical kinetic therapy is realized, two enzymes are conveyed to a target site of an organism with the carrier on the basis of biocompatibility of the erythrocyte membrane and tumor targeting of targeting molecules, accurate administration is realized by membrane rupture based on 808 nm near-infrared light illumination in the tumors, the problem of drug resistance is solved effectively, furthermore,systemic toxicity caused by drug application is remarkably reduced, and damage to other normal tissue in an in-vivo circulation process is prevented effectively. The invention further provides the preparation method of the bionic binary cooperative nano-carrier. The bionic binary cooperative nano-carrier and the preparation method have good application prospect.

The invention relates to a preparation method and application of a multifunctional nano siRNA (Small Interfering Ribonucleic Acid) carrier system which integrates tumor targeting, pH sensitivity, visualization and the like. The core of the siRNA nano carrier system consists of cadmium telluride quantum dots. A nano carrier shell consists of a tumor targeted gene, a 9 poly-l-arginine peptide chain and PEG (Polyethylene Glycol). The siRNA nano carrier is good in biocompatibility, strong in tumor targeting and high in cell transfection efficiency, and has the characteristics of high quantum yield, strong optical stability, lossless in-position real-time monitoring and the like, so that the system is suitable for being used as a nano transmission system for in vivo gene therapy of tumors.

The invention relates to a natural sericin encapsulated mesoporous silicon nano-carrier and a preparation method and application thereof to the field of tumor treatment. The preparation method comprises the steps of preparing pure sericin solids; preparing mesoporous silicon nano-particles; preparing aminated, formylated or dual-sulfurated mesoporous silicon nano-particles with regular pore passage; preparing drug-loaded aminated, formylated or dual-sulfurated mesoporous silicon nano-particles; preparing a pH / protease or reduction / protease dual-responsiveness sericin / mesoporous silicon composite multifunctional control system. The natural sericin encapsulated mesoporous silicon nano-carrier and the preparation method and the application thereof have the advantages that the operation is simple to perform, the raw materials are simple and convenient to obtain, the cost is low, the universal applicability is high, no special complex equipment is needed and the like. The nano composite system prepared by adopting the method fully utilizes the characteristics of the sericin on the outer layer and the mesoporous silicon nano-particles on the inner layer, has pH / protease or reduction / protease dual responsiveness, has multiple functions of inhibiting tumor cells, monitoring nano-particle positioning and drug release in real time and the like, is high is drug loading capacity, is good in biocompatibility and has a wide application prospect in the field of tumor diagnosis and treatment, especially in the aspect of solving multi-drug resistance of tumors.

The invention belongs to the field of bio-medicine, and discloses a magnetic resonance imaging nano-carrier, a nano drug carrier system and a preparation method thereof. According to the invention, two targeting molecules, namely folic acid and cell-penetrating peptide, are adopted, so that a targeting effect on tumors is improved, and meanwhile, anti-tumor activity in vitro and in vivo is enhanced. PLGA, which is low in toxicity and good in biocompatibility, is taken as the anti-tumor drug carrier, and the terminal of the PLGA is modified with CS, so that the functional nano-system is prepared. Meanwhile, nuclear magnetic imaging drugs and anti-tumor drugs are effectively loaded, so that the anti-tumor drugs can reach a tumor focus part in a specific mode, and tumor region nuclear magnetic localization of ferroferric oxide nanoparticles can be implemented; and meanwhile, a therapeutic effect with high selectivity and low toxicity can be achieved. With the application of the invention,shortcomings of conventional cytotoxic drugs which are poor in selectivity, relatively strong in toxic and side effects, capable of causing drug tolerance easily and the like can be overcome; and a utilization degree of the anti-tumor drugs can be improved and toxic and side effects can be reduced. The preparation method of the drug carrier system is simple and easy to implement; and the preparedproduct (the drug carrier system) is good in repeatability and stability.

The invention belongs to the technical field of biomedical polymer material and nanobiomaterial, particularly relates to a magnetic nano-carrier with targeted hydrophobic drug delivery to tumor and a preparation method thereof. The magnetic nano-carrier is formed by encapsulating superparamagnetic nano-particles with amphiphilic segmented copolymer methoxy polye thylene glycol-poly(lactide- glycolide) (MePEG-PLGA) micelles. First, a large amount of MePEG-PLGA with good dispersion is synthesized by the improved solution polymerization process, and then the MePEG-PLGA is used as raw materials to encapsulate Fe3O4 nano-particles by the solvent evaporation process to obtain a magnetic nano drug carrier. The carrier is expected to solve the solubility problem of insoluble drugs, achieves slow release of drugs, and achieves the passive-targeting of the drugs by the EPR effect of tumor; Fe3O4 nano-particles are used in the active-targeting of the drugs to reduce the dosage and the side effect and improve the treatment efficiency; besides, the carrier can be used in the magnetic resonance imaging (MRI) of tumor.

The invention discloses a nano carrier loaded with tetrahydrocurcumin and a preparation method thereof. The key points of the preparation method are as follows: heating, melting and stirring evenly a composite lipid material and a water-in-oil emulsifying agent to obtain oil phase; then heating and evenly stirring the water-in-oil emulsifying agent and deionized water to obtain water phase; adding tetrahydrocurcumin into the oil phase and mixing evenly at a temperature of 50-70 DEG C; adding well stirred water phase into the oil phase mixture, heating and evenly stirring, cooling and solidifying to obtain the nano carrier loaded with tetrahydrocurcumin. The nano structured lipid carrier has good stability and compatibility; moreover, the bioavailability is relatively high, the preparation method is simple and controllable, and the repeatability is good. Therefore, the nano carrier can be well applied to the preparation of cosmetics containing curcumin.

The invention belongs to the field of biological medicine and specifically discloses a nucleic acid-drug conjugate based on phosphorothioate modified nucleic acid, a drug delivery system and a preparation method thereof. Phosphorothioate groups in the phosphorothioate modified nucleic acid react with groups modified on drug molecules and capable of generating electrophilic reaction with the phosphorothioate groups, so as to form the nucleic acid-drug conjugate; the nucleic acid-drug conjugate can be self-assembled into drug-containing nano-carriers in various forms for drug delivery, in the manner of selecting different nucleotide sequences including functional nucleic acid; compared with the prior art, the invention has the advantages that the nucleic acid-drug conjugate can be acquired through a simple solid-phase synthesis technology, grafting sites and assembling forms of drug molecules on nucleic acid skeleton can be accurately controlled and the method has universality to chemotherapeutic drugs; according to the nucleic acid-drug conjugate, the drug delivery system, the preparation method and the application thereof disclosed by the invention, physicochemical properties and in vivo distribution properties of chemotherapeutic drugs are obviously improved, therapeutic effect thereof can be promoted and combination therapy of gene therapy and chemotherapy can be realized.

The invention provides a serial cell-penetrating peptide modified tumor targeted and tumor penetrated nano drug delivery system capable of simultaneously identifying an integrin receptor and a transmembrane protein receptor, wherein the serial cell-penetrating peptide is mainly formed by connecting a DGR polypeptide fragment covalently at the C-tail end of polyarginine of the cell-penetrating peptide. The polypeptide not only can selectively identify two highly expressed receptors on the surfaces of the tumor cells, but also can be efficiently mediated into the cells. The nano drug delivery system mainly consists of a nano carrier, a drug and a lipid-polyethylene glycol-serial cell-penetrating peptide ligand interstitial compound and is a potential tumor targeted treatment carrier.

The invention provides a targeting nano carrier bearing nucleoside anti-tumor drugs and preparation method and application thereof. The targeting nano carrier comprises DNA tetrahedron, Affibody molecule and nucleoside anti-tumor drugs. The preparation method comprises the following steps: a, the nucleoside anti-tumor drugs are modified with phosphoramidite; B, synthesizing four DNA single strandsby DNA solid phase synthesis technology, integrating the nucleoside anti-tumor drugs into the 5 'ends of the four DNA single strands, and modifying NH2 at the 3' ends of one of the DNA single strands; C, linking the affibody molecule to the 3 'end of the NH2-modified DNA single strand through a linker; (d) mix and assembling that four DNA single strand in a molar ratio of 1: 1: 1: 1 to obtain DNAtetrahedron; and (d) assembling the four DNA single strands in a molar ratio of 1: 1: 1 to obtain DNA tetrahedron; Affibody targeting nanoparticles. The targeting nano carrier of the invention can precisely control the combined quantity of drugs, has faster tumor targeting ability and higher cell, tissue penetration ability, good pharmaceutical effect, and is suitable for popularization and application.

The invention discloses folate-conjugated polyethylene glycol monostearate, and a preparation method and application thereof. The folate-conjugated polyethylene glycol monostearate has a structure shown as below, wherein n equals to 45-136. The preparation method of the folate-conjugated polyethylene glycol monostearate comprises the following steps: weighing folic acid and triethylamine; adding dimethylsulfoxide for dissolution; adding dicyclohexylcarbodiimide and N-hydroxy succinimide; stirring at room temperature by avoiding light; standing for overnight; filtering to remove by-products; then adding polyethylene glycol monostearate; heating to dissolve; reacting overnight to obtain a coarse product; placing the coarse product in a dialysis bag; dialyzing with water; and conducting freeze-drying to obtain the folate-conjugated polyethylene glycol monostearate. The folate-conjugated polyethylene glycol monostearate can be applied to preparation of a folic acid modified antitumor drug delivery system, improve drug targeting, efficacy and pharmacokinetics, and reduce toxicity.

A method of preparing nano-carriers is disclosed. The method includes mixing an organic solution of a drug and an organic solution of a biological agent separately with a predetermined amount of water having one or more dissolved surfactants to obtain a first mixture and a second mixture respectively. Subsequently, the first mixture and the second mixture are homogenized separately to obtain a solution of nano-crystals of the drug and a solution of nano-particles of the biological agent respectively. Thereafter, the solution of nano-crystals of the drug and the solution of nano-particles of the biological agent are together subjected to an ultra-sound homogenization to obtain a solution of nano-carriers. An interfacial extraction and / or a dialysis are then performed on the solution of nano-carriers to obtain the nano-carriers. Formulations of the nano-carriers are also disclosed.

The invention belongs to the technical field of biomedical polymer materials and nano-biotechnology and particularly relates to a targeting ligand modified reduction-responsive magnetic nano carrier and a preparation method thereof; the nano carrier is of typical core-shell structure, using superparamagnetic Fe3O4 nanoparticles to form a core wrapped in a reduction-responsive amphiphilic polymer; the reduction-responsive amphiphilic polymer is formed by linking hydrophobic groups to a hydrophilic polymer through linkers with reduction-sensitive bonds; the amphiphilic polymer forms the shell structure of the nano carrier, and target ligands are attached to the surface of the shell under the action of electrostatic adsorption. The carrier is used for carrying hydrophobic antitumor drugs and carrying out MRI (magnetic resonance imaging). The carrier and the preparation method thereof have the advantages that the carrier is able to target at multiple tumors, antitumor efficiency is improved, and toxic and side effects on normal tissues and organs are lowered; the targeting ligands are adsorbed via electrostatic adsorption, no chemical reaction is required, and time and cost are saved; the carrier may respond quickly to tumor high-GSH (high glutathione) microenvironment, allows a drug to be released quickly in tumor cells, and provides enhanced tumor inhibitory action.

The invention relates to the technical field of medicines, and relates to adriamycin-indocyanine green bionic nanoparticles coated with platelet and neutrophil fusion membranes and an application of the adriamycin-indocyanine green bionic nanoparticles in preparation of medicines for treating tumor metastasis diseases. The bionic nanoparticle coated with the platelet and neutrophil hybrid membranecomprises adriamycin, indocyanine green, a nano carrier material, a platelet membrane and a neutrophil hybrid membrane, which is characterized by comprising the following components in percentage byweight: 8 to 10 percent of doxorubicin, 8 to 10 percent of indocyanine green, 30 to 40 percent of nano carrier material and the balance of platelet and neutrophile granulocyte hybrid membrane. The bionic nanoparticle has the capability of simultaneously capturing and removing circulating tumor cells and tumor-derived exosomes through a high-affinity membrane adhesion receptor, and effectively cutsoff the relationship between the exosomes and immune cells. The primary tumor can be completely ablated, and breast cancer metastasis can be efficiently inhibited in xenograft and in-situ breast tumor models.

The invention discloses a nano-drug system capable of realizing light-controlled release of CO and doxorubicin (DOX) as well as preparation and application of the nano-drug system. The nano-drug system takes polydopamine (PDA) as a nano-carrier, and pentacarbonyl manganese bromide and the DOX are supported on the PDA. The preparation method of the nano-drug system is simple. Dopamine hydrochlorideis dispersed into double-distilled water to obtain a dopamine hydrochloride solution, a NaOH solution is added, repeated centrifugal separation is carried out to obtain PDA, the PDA is dispersed in the double-distilled water, an ethanol solution of pentacarbonyl manganese bromide and the double-distilled water solution of DOX are added under violent stirring, rotary stirring is carried out at room temperature to obtain a black solution, a supernatant is removed by centrifugal separation, and an obtained precipitate is PDA-DOX-CO nanoparticles. The nano-drug system can controllably release theCO and the DOX under near-infrared light irradiation, effectively inhibit tumor growth, and has a good long-circulation function, biocompatibility and stability.

The invention relates to the technical field of medicines, in particular to a lipoic acid modified intrinsically disordered protein nano-carrier, a preparation method thereof and an application of the nano-carrier. The nano-carrier is crosslinked by disulfide bonds of lipoic acid, formed polypeptide polymer can be rapidly degraded in cells and cannot be accumulated in the cells, and amino acid forming a polypeptide carrier exists in vivo and has no toxic and side effects on the cells and a human body. CCK-8 cell proliferation assay indicates that the prepared nano-carrier has low cell toxicity and good gene and chemotherapeutic drug co-carrier capacity, can successfully deliver sensitivity of autophagic specificity enhanced cancer cells to chemotherapeutic drugs caused by siRNA suppressive chemotherapeutic drugs in breast cancer therapy, promotes breast cancer cell apoptosis and accordingly becomes a targeted, efficient and low-toxicity nano-scale delivery system in breast cancer therapy.

The invention provides self-detection anticorrosive paint with nano-carriers, a preparation method of the paint and an application. The self-detection anticorrosive paint comprises a self-detection color material, the nano-carriers and a film-forming substrate. The method for preparing the self-detection anticorrosive paint with the nano-carriers includes the steps: firstly, preparing the nano-carriers, and configuring the nano-carriers into nano-carrier water solution with a certain proportional concentration; secondly, mixing the nano-carrier water solution and the self-detection color material in proportion to obtain first mixed liquid; thirdly, performing ultrasonic dispersion for the first mixed liquid to obtain second mixed liquid; fourthly, drawing, filtering and removing unreacted solution in the second mixed liquid to obtain a solid matter, and adding water into the solid matter to form third mixed liquid with a certain proportion by matching; fifthly, mixing the third mixed liquid and the film-forming substrate to obtain the anticorrosive paint. The self-detection anticorrosive paint is environmentally friendly and has the functions of automatic detection, early warning and corrosion prevention.

The invention belongs to the field of high polymer chemistry and biomedical engineering, and particularly relates to a multi-functional stimuli sensitive polymer-gold nanocage carrier and a preparation method thereof. The multi-functional carrier has a nucleus-shell-crown structure formed by a nucleus, a shell and a crown; the nucleus is formed by polymeric micelles, the shell is formed by gold nanocages, and the crown is formed by methoxy polyethylene glycol-branched polyethylenimine-lipoic acid; and the nano-carrier has a good photothermal conversion effect on the condition of 808 nm. The carrier has low toxicity for cells and can bear not only drugs but also genes or nucleic acids, thereby achieving the integration of carrier positioning, chemotherapy, thermal therapy and gene therapy and having a wide application value.

The invention discloses a lipoic acid modified chondroitin sulfate-chlorin e6 amphoteric polymer. According to the polymer, chondroitin sulfate is used as a water-soluble framework material, chlorin e6 serves as a hydrophobic modifier to be connected into a chondroitin sulfate framework, lipoic acid is used as an interface cross-linking agent to conduct surface modification on a chondroitin sulfate-chlorin e6 polymer, and the polymer further has a hydrophobic core to be capable of entrapping an insoluble anti-tumor drug. The lipoic acid modified chondroitin sulfate-chlorin e6 amphoteric polymer prepared by the invention is used as a drug carrier to prepare reversible cross-linked nano-micelles, and thus rapid decrosslinking in tumor cells can be realized; and as an excellent nano-carrier,sonodynamic therapy (SDT) of the tumors is achieved, and the lipoic acid modified chondroitin sulfate-chlorin e6 amphoteric polymer has the effects of increasing the level of active oxygen in the cells, promoting tumor cell apoptosis and remarkably inhibiting tumor cell growth. Meanwhile, the hydrophobic core provides entrapment of the anti-tumor drug, combined application of chemotherapy and SDTof the tumors can be achieved, and the anti-tumor effect is expected to be improved.