117 results about "Structured lipid" patented technology

The invention discloses an application of nanometer structure lipid carrier administration system in the antineoplastic drug to reverse the multiple-drug tolerance of tumour cell, which comprises the following parts: solid lipid material, liquid lipid material and antineoplastic drug, wherein the rate of the liquid lipid (such as oleic acid) is 0-30wt%; the solid lipid is selected from monoglyceride; the liquid lipid is oleic acid; the antineoplastic drug is Paclitaxel or adriablastina. The invention has highly effective cell uptaking and cytolymph condensing function with packing molecular target in the antineoplastic drug of cell, which avoids P-glucoprotein in the drug tolerant cytolymph from identifying the antineoplastic drug to reduce exclusion.

A microencapsulated product comprises a core, a first shell comprising a protein and being substantially carbohydrate-free, and a second shell comprising a carbohydrate and being substantially protein-free. The double shell structure provides a strong shell that makes the microcapsule suitable for use in food products. The core can be a lipid, and in particular a structured lipid with nutritional benefits, such that the nutritional benefits can be passed on to the consumer. The microcapsules of the present invention can be used in making foods products, beverage products, and mixes for making such food and beverage products.

Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more —OH (hydroxyl) groups; b) a phospholipid; and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. The lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid. Also, a pharmaceutical composition further comprising a pharmacologically active ingredient plus the pre-concentrate is provided.

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and / or prophylactics such as RNA are useful in the delivery of therapeutic and / or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

The invention provides methods for making Maillard flavor compositions in a structured lipid phase using Maillard reactants, e.g., reducing sugars and amino groups. The structured lipid phase comprises from about 0.3% to about 95% aqueous solvent and from about 5% to about 99.7% lipid plus emulsifier. The compositions are useful for enhancing the palatability of foods, dietary supplements, medicaments, and the like.

A novel oil composition comprises an interesterified structured lipid component, the component being an interesterifcation reaction product of an amount of a medium chain triglyceride, an amount of a long chain domestic oil, and an amount of a conjugated linoleic acid material. The structured lipid component can be used in edible oil compositions. The oil compositions advantageously can contain an amount of a phytosterol ester component, up to about 12 weight percent of the total composition. The oil compositions disclosed herein have good stability and also have other properties useful for an edible oil composition.

The invention relates to candida Antarctica lipase B gene and applications thereof in yeast display. Coded protein of improved candida Antarctica B and wild type candida Antarctica lipase protein have the same function on the amino acid level; the heat resistance capacity of the enzyme is 50-80 DEG C, and the half-lift is 3-24 hours; a nucleotide sequence is hybridized with SEQ.ID.NO2 from 1st to 978th of nucleotide under the moderate precise condition; and a preservation number of colon bacillus DH5Alpha / Puc57-CALB (Escherichia coliDH5Alpha / pUC57-CALB) which carries the plasmids is CCTCC M 209081. The candida Antarctica lipase B gene is transferred into pichia pastoris host bacteria so as to realize the high-efficient display expression of the candida Antarctica lipase B in pichia pastoris; and the provided pichia pastoris bacteria can effectively display candida Antarctica lipase B, can be widely applied to the synthesis of ethyl caproate, has different melting points and does not contain triglyceride of various fatty acids, a plurality of structured lipids, and the like.

Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes.

A method is disclosed for making reduced calorie cultured cheeses whereby the natural lipid content of milk is replaced with colloidal forms of synthetic or chemically structured lipids displaying low to no human digestibility. The colloidal dispersion of modified lipids contained within the milk base is initially stabilized by preferred combinations of polymeric and particulate hydrocolloidal materials such as structurally expanded cellulose. Such stabilization is important during formation of the curd to ensure homogeneous distribution and maintenance of the lipid dispersion throughout the coagulum yet allow effective concentration of the coagulum solids by means of ordinary water removal methods commonly used in the manufacture of conventional cultured cheeses. The coagulum is then processed by means similar to that employed for naturally fermented cheeses. The resulting cultured cheese is a reduced calorie product with low to no metabolizable fat content yet possesses organoleptic properties similar to a full fat product.

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and / or prophylactics such as RNA are useful in the delivery of therapeutic and / or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and / or prophylactics such as RNA are useful in the delivery of therapeutic and / or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Lipid compositions comprising specific mixtures of edible synthetic triglycerides are provided that are useful in formulating food products having highly desirable dietary benefits. The novel lipid compositions allow simultaneous access to highly desirable dietary benefits such as delivery of calorie reduction, weight management, health benefits, or any combination thereof, and they also may be formulated trans-fatty acid free.

The invention relates to a nanostructured lipid carrier (NLC) for a composite skin lightener. The composite skin lightener is loaded on the carrier and comprises the following three active ingredients in percentage by weight: 1-50% of phenylethyl resorcinol, 40-89% of turmeric extract, and 1-10% of pepper seed extract; the carrier further comprises an NLC composite lipid material and an emulsifying agent; and the content of the composite skin lightener in percentage by weight is 1-15%. The composite skin lightener is enveloped by using the NLC; and the enveloping process is simple, controllable, and good in repeatability, and overcomes the application bottlenecks that the active substances are not soluble in water, and easily degrades on meeting light to cause color change, and rapid content decease.

The invention discloses a method for determining compositions of fatty acids and acylglycerols at alpha and beta positions of structured lipid by combining solid-phase extraction and gas chromatography. The method comprises utilizing pure arachidonic acid-triacylglycerol (ARA-TAG), docosahexaenoic acid-diacylglycerol (DAH-DAG), linolenic acid- monoacylglycerol (Ln-MAG) and an oleic acid-free fatty acid (O-FFA) standard sample, and optimizing eluent elution conditions with different polarity ratios, so as to effectively separate TAG, DAG, MAG and FFA in mixtures in a same SPE (Solid Phase Extraction) microcolumn; and the method is characterized by also comprising the following steps: 1) separation of a mixed standard sample and analysis on compositions of fatty acids; and 2) analysis on compositions of fatty acids and acylglycerols at alpha and beta positions of the structured lipid. The method has the advantages of simple operation, low sample demanded amount, less consumption amount of a needed solvent, accurate qualitative quantitative analysis results, low detection limit and short analysis time, and is capable of realizing high-flux detection on TAG, DAG, MAG and FFA compositions and content in structured lipid and compositions of fatty acids at alpha and beta positions of structured lipid.

The invention discloses an enzymatic acidolysis-based method for synthesizing structured lipids from palmitic acid triglycerides. The method comprises the following steps: saponifying and refluxing an oil raw material and a solvent in nitrogen; after complete hydrolysis, recovering the solvent in a spin steaming manner, and regulating the pH value of a hydrolysis mixture; extracting free fatty acids after washing, removing water from anhydrous magnesium sulfate and filtering so as to obtain filtrate; carrying out spin steaming on the filtrate, so as to obtain the free fatty acids; and mixing at least one of the free fatty acids with the palmitic acid triglycerides, and preparing the structured lipids under the action of the sn-1,3-bit specific lipase. According to the method, the palmitic acid triglycerides and the fatty acids are catalyzed by the sn-1,3-bit specific lipase to directionally synthesize the structured lipids; MLM-type structured lipids are prepared from short-carbon chain saturated fatty acids and the palmitic acid triglycerides, which are easy to digest and absorb, in a manner of enzymatic acidolysis; meanwhile, LPL-type structured lipids are prepared from long-chain unsaturated fatty acids and the palmitic acid triglycerides, which are essential to the body, in the manner of enzymatic acidolysis; and different types of structured lipids can be configured according to the different nutritional requirements of different people.

The invention discloses 5'-amino-2',5'-dideoxynucleotide phospholipid molecules, and a preparation method and an application thereof. The 5'-amino-2',5'-dideoxynucleotide phospholipid molecules provided by the invention have an amphiphilic structure represented by the formula (I). 5'-amino-2',5'-dideoxynucleoside is adopted as a hydrophilic head, and glycerol fatty ether connected by using a phosphate bond is adopted as a hydrophobic tail, such that an amphiphilic molecule is formed. The Base group is common purine and pyrimidine bases, and R group is saturated or unsaturated aliphatic carbon chain. In a water-phase solvent, the dideoxynucleotide phospholipid molecule can form a plurality of supramolecular structures including multi-layer film structure, lipid structure, fibrous structure, and hydrogel. Therefore, 5'-amino-2',5'-dideoxynucleotide phospholipid molecules have certain potential to be used as aggregation, trapping, loading, or carrying type nucleic acid medicines, and can be used as a high-efficiency biological material for mediating transmembrane of nucleic acid medicines.

The invention discloses a nano carrier loaded with tetrahydrocurcumin and a preparation method thereof. The key points of the preparation method are as follows: heating, melting and stirring evenly a composite lipid material and a water-in-oil emulsifying agent to obtain oil phase; then heating and evenly stirring the water-in-oil emulsifying agent and deionized water to obtain water phase; adding tetrahydrocurcumin into the oil phase and mixing evenly at a temperature of 50-70 DEG C; adding well stirred water phase into the oil phase mixture, heating and evenly stirring, cooling and solidifying to obtain the nano carrier loaded with tetrahydrocurcumin. The nano structured lipid carrier has good stability and compatibility; moreover, the bioavailability is relatively high, the preparation method is simple and controllable, and the repeatability is good. Therefore, the nano carrier can be well applied to the preparation of cosmetics containing curcumin.

PURPOSE: A method for preparing a nanostrucutured lipid carrier or nanoemulsion is provided to reduce inflammation and to ensure chemical stability. CONSTITUTION: A method for preparing a nanostrucutured lipid carrier or nanoemulsion comprises: a step of dissolving an oil phase at higher temperature than the temperature of an oil phase containing solid lipid, liquid lipid, or mixture thereof and lipophilic and hydrophilic surfactant; a step of adding active ingredients to the dissolved oil phase; a step of homogenizing the oil phase; a step of mixing the oil phase with a first aqueous solution and preheating; a step of forming pre-emulsion; and a step of homogenizing the pre-emulsion.

The invention relates to a clevidipine butyrate structured lipid emulsion which comprises clevidipine butyrate, structured triglyceride, an emulsifier, an isotonic agent, a pH regulator, and injection water, wherein the weight volume percentage of clevidipine butyrate is 0.05-0.1% (w / v); the weight volume percentage of structured triglyceride is 5-30% (w / v); the weight volume percentage of the emulsifier is 1.0-2.0% (w / v); and the weight volume percentage of the isotonic agent is 1.0-5.0% (w / v).

The invention discloses a lipase mutant with improved enzyme activity and regioselectivity and application of the mutant and belongs to the technical field of gene engineering. According to the lipasemutant, wild-type lipase is mutated, the enzyme activity of mutants M8A, L10A, D11A, L12A and P17G is increased by 1.1-2.4 times compared with the enzyme activity of wild-type lipase, and the 1,3-regioselectivity of the mutants M8A, L10A and T9A is increased by 4.75-5 times compared with the regioselectivity of wild-type lipase. The enzyme activity and regioselectivity are important parameters ofthe lipase mutant in structural lipid catalytic application. The lipase mutant is applied to a catalytic reaction of human milk fat substitutes and has an obvious effect.

Unique structured lipids obtained from interesterifying coconut oil with free fatty acids obtained from hydrolysis of triglycerides of vegetable source, said structured lipids rich in omega 6 polyunsaturated fatty acids and medium chain fatty acids and a process for the production of said structural lipids.

The invention provides a humanized infant formula milk powder which contains nucleotides and OPO structured lipid, and is used for infants of 0 to 12 months older, and a preparation method thereof. In the humanized infant formula milk powder, the content of total protein ranges from 10.5 to 18g / 100g, the amount of whey protein accounts for 48 to 61% of that of total protein, the content of alpha-whey protein ranges from 1.25 to 1.8g / 100g, the content of beta-casein ranges from 2.2 to 3.7g / 100g, the content of fat ranges from 20 to 29g / 100g, the content of linoleic acid ranges from 2600 to 4500mg / 100g, the content of alpha-linolenic acid ranges from 330 to 450mg / 100g, the content of 1,3-dioleoyl-2-palmitoylglycerol ranges from 3 to 5g / 100g, the content of carbohydrate ranges from 52 to 56g / 100g, and the content of total nucleotides ranges from 26 to 58mg / 100g in total nucleotide molecular weight. The humanized infant formula milk powder is more similar to breast milk, and is capable of improving infant immunity.

A microencapsulated product comprises a core, a first shell comprising a protein and being substantially carbohydrate-free, and a second shell comprising a carbohydrate and being substantially protein-free. The double shell structure provides a strong shell that makes the microcapsule suitable for use in food products. The core can be a lipid, and in particular a structured lipid with nutritional benefits, such that the nutritional benefits can be passed on to the consumer. The microcapsules of the present invention can be used in making foods products, beverage products, and mixes for making such food and beverage products.

The invention discloses a salicylic acid nanostructured lipid carrier, which comprises the following components in percentage by mass: 1 to 5% of salicylic acid, 10 to 30% of composite lipid material, 5 to 15% of emulsifier, and the balance of deionized water, wherein the composite lipid material is a solid-liquid lipid material, a solid lipid material is one or more of glyceryl monostearate, shea butter, acetylated monoglyceride and spermaceti wax, and a liquid lipid material is one or more of glyceryl caprylate caprate, diethyl sebacate, castor oil, and isopropyl myristate. The invention also discloses a preparation method and application of the salicylic acid nanostructured lipid carrier. Salicylic acid is embedded by a nanostructured carrier technology, so that large amounts of free salicylic acid are not in direct contact with the skin to reduce the irritation of the salicylic acid, and the release of salicylic acid is favorably controlled, and salicylic acid can be ensured to be effective at the surface concentration by utilizing controlled release and sustained release.

A composition in the form of a dry powder and which comprises: a) at least one membrane lipid, and b) at least one biologically active compound comprising a xanthine and / or a carboxylic acid, and which forms structured lipid assemblies when dispersed / dissolved in an aqueous medium. A method of preparing such a composition is also provided, together with a dispersion of structured lipid assemblies suspended in a solution of at least one biologically active compound and a method of preparing the same. The compositions and dispersions are suitable for use in creams and lotions for skin care.

The invention provides methods for making Maillard flavor compositions in a structured lipid phase using Maillard reactants, e.g., reducing sugars and amino groups. The structured lipid phase comprises from about 0.3% to about 95% aqueous solvent and from about 5% to about 99.7% lipid plus emulsifier. The compositions are useful for enhancing the palatability of foods, dietary supplements, medicaments, and the like.

The present invention relates to a nutritional composition, such as an infant formula composition or an enteral composition for children 3-17 years, that is especially targeted as patients having food allergies or impairments of intestinal absorption. The composition comprises structured lipids. The composition is based on free amino acids and contains a very low amount of peptides or proteins, if any. The composition comprises a source of carbohydrate and has a particular caloric density. The composition can comprise arachidonic acid (ARA) and / or docosahexaenoic acid (DHA). The composition delivers specific nutritional benefits to the patients.

The invention discloses a quercetin nanostructured lipid carrier and a preparation method thereof, wherein the quercetin nanostructured lipid carrier comprises the following components by weight percent: 0.1-1% of quercetin, 2%-15% of an emulsifying agent, 2%-15% of compound lipid material and the balance being water. The compound lipid material is a solid-liquid state lipid mixture; the solid lipid is one or more of acetylation monoglyceride, stearate, glyceryl monostearate and monolaurate; the liquid lipid is one or more of decanoyl / octanoyl-glycerides, camellia oleosa seed oil, soybean oil and peanut oil. The quercetin is loaded by utilizing a nanostructured lipid carrier technique, on the one hand, the sensibility of the quercetin to the environmental factors such as illumination and temperature can be reduced, and the chemical stability is improved, and on the other hand, the solubility of the quercetin in water can be improved, thereby improving the bioavailability. The preparation method is simple and controllable, and is good in reproducibility; the quercetin nanostructured lipid carrier emulsion prepared by the method is suitable for being added into functional food beverages.

Lipid compositions are provided exhibiting the functionality of a typical shortening or filler fat, but are achieved with reduced and essentially zero trans-unsaturated fatty acids and that deliver reduced caloric content. By one approach, the functional lipid compositions include a blend of a matrix building ingredient, which is preferably a structured glycerol ester, and an edible liquid oil diluent in ratios such that the lipid composition exhibits the functionality of the traditional shortening or filler fat.