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Method for preparing nanostructured lipid carrier (nlc) and product

A nanostructured lipid and carrier technology, applied in liposome delivery, nanotechnology, nanotechnology, etc., can solve the problems of high heating stability and heating process reduction

Inactive Publication Date: 2011-12-21
马来西亚棕油理事会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, higher heating stability and longer heating process reduce the stability of the active ingredient

Method used

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  • Method for preparing nanostructured lipid carrier (nlc) and product
  • Method for preparing nanostructured lipid carrier (nlc) and product
  • Method for preparing nanostructured lipid carrier (nlc) and product

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preparation example Construction

[0025] The present invention relates to a preparation method of nanostructure lipid carrier (nanostructure lipid carrier, NLC) or nanoemulsion (nano-emulsion), comprising combining an oil phase containing solid lipid, liquid lipid or a combination thereof with lipophilic surface active The liquefaction is carried out at a temperature higher than the melting point of the oil phase to avoid recrystallization of the oil phase; the active ingredient is added to the liquefied oil phase, after which the oil phase is mixed into a In the water phase to form a mixture, wherein, when the oil phase is mixed with the water phase, the water phase is preheated to a temperature that can avoid recrystallization of the oil phase; a pre-emulsion (pre-emulsion) is formed from the mixture; Preemulsion homogenization is used to provide the nanostructured lipid vehicle; characterized by cooling the formed preemulsion and / or nanostructured lipid vehicle.

[0026] In addition, the present invention f...

Embodiment 1

[0040] The present invention has successfully developed and established an improved production method. Specifically, a low-temperature production technique was developed to minimize activity loss. This improved method reduces the heating temperature of the oil phase and water compared with the existing established method. The purpose of the surfactant in the water phase is to facilitate its heating to 10° C. above the heating temperature of the oil phase, so as to avoid recrystallization of the oil phase. Likewise, the heating temperature for the second homogenization (high pressure homogenization) was also lowered. In addition, the newly added steps also minimize the loss of active ingredients during the production process. The newly added steps include the following: adding the active substance after reaching the expected temperature, and adopting a rapid cooling step after high shear and high pressure homogenization, respectively. After homogenization, the kinetic energy...

Embodiment 2

[0047] Although the modified method has been proven to be effective in minimizing the degradation of the active ingredient, the method can still be further improved, because the temperature increase of the pre-emulsion during the homogenization process will also lead to the degradation of the active ingredient. Therefore, the improved method requires a profound improvement, namely lowering the temperature of the homogenization process. This second change method is the in-depth improvement method mentioned above when referring to the improvement method. The products of the improved method and the further improved method are the same. The only difference is the pre-preparation of the pre-emulsion. For the modified method, hydrophilic surfactants are added to the water phase and lipophilic surfactants are added to the oil phase. However, evaporation of the aqueous phase in the modified process causes loss of the hydrophilic surfactant. Therefore, in a further improvement metho...

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Abstract

PURPOSE: A method for preparing a nanostrucutured lipid carrier or nanoemulsion is provided to reduce inflammation and to ensure chemical stability. CONSTITUTION: A method for preparing a nanostrucutured lipid carrier or nanoemulsion comprises: a step of dissolving an oil phase at higher temperature than the temperature of an oil phase containing solid lipid, liquid lipid, or mixture thereof and lipophilic and hydrophilic surfactant; a step of adding active ingredients to the dissolved oil phase; a step of homogenizing the oil phase; a step of mixing the oil phase with a first aqueous solution and preheating; a step of forming pre-emulsion; and a step of homogenizing the pre-emulsion.

Description

technical field [0001] The present invention relates to a method of producing NLC, wherein the NLC not only serves as a delivery system, but is capable of retaining a large amount of active ingredients in it - especially antioxidants, without degrading most of the active ingredients in the process. Background technique [0002] Nanostructured lipid carrier (NLC), which is composed of solid lipid as matrix and added a certain amount of liquid lipid, is regarded as the new generation of solid nanoparticles. NLC has been recognized in the field of cosmetics for its ability to improve the chemical stability of active ingredients, increase skin hydration through occlusive effects, increase the bioavailability of active ingredients on the skin, and increase the physical stability of topical formulations. received great attention. Due to the above characteristics, NLC is considered as an ideal delivery system for active ingredients (such as carotene, tocol, coenzyme Q, etc.) used ...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K9/107A61K47/44A61K36/889
CPCA61K9/107A61K9/127A61K47/38B82Y5/00B82Y40/00
Inventor 罗斯纳·伊斯梅尔卢秋虹哈里森·刘利南哈紫曼·阿布·哈桑朱云美马海蓝·巴斯瑞比卜·瓦里奥·特茹
Owner 马来西亚棕油理事会
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