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Nano carrier loaded with tetrahydrocurcumin and preparation method thereof

A technology of tetrahydrocurcumin and nano-carrier is applied in the directions of skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., to achieve the effects of good repeatability, good stability and compatibility, and high bioavailability

Inactive Publication Date: 2014-03-26
苏州纳康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the problems of poor stability and low bioavailability of tetrahydrocurcumin, its development and application are limited to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The nanocarrier of loaded tetrahydrocurcumin, its formula is:

[0027] Tetrahydrocurcumin 5g

[0028] Glyceryl Monolaurate 2g

[0029] Acetylated Monoglycerides 10g

[0030] Glyceryl Triacetate 5g

[0031] Luba Gum Oil 2g

[0032] Polyoxyethylene (21) stearyl ether 8g

[0033] Polyoxyl 40 stearate 3g

[0034] Polyoxyethylene sorbitan monooleate 5g

[0035] Deionized water 60g

[0036] Total 100g

[0037] Its preparation method is:

[0038] 1. Take 2g of glyceryl monolaurate, 10g of acetylated monoglyceride, 5g of triacetin, 2g of Luba gum oil, and 8g of polyoxyethylene (21) stearyl ether in a 150ml beaker. Heat in a water bath at 65°C and stir to dissolve completely, as the oil phase;

[0039] 2. Take a 150ml beaker, pour 3g of polyoxyl 40 stearate, 5g of polyoxyethylene sorbitan monooleate, and 60g of deionized water into the beaker, heat it in a 65°C water bath, and stir to make it Mix well, as the water phase;

[0040] 3. Weigh 5g tetrahydrocurcumin and a...

Embodiment 2

[0044] The nanocarrier of loaded tetrahydrocurcumin, its formula is:

[0045] Tetrahydrocurcumin 5g

[0046] Glyceryl monostearate 2g

[0047] Acetylated Monoglycerides 10g

[0048] Glyceryl Triacetate 5g

[0049] Glyceryl Caprylate 5g

[0050] Luba Gum Oil 2g

[0051] OLIVEM1000 6g

[0052] Polyoxyethylene (21) stearyl ether 5g

[0053] Laureth 3g

[0054] Polyoxyl 40 stearate 3g

[0055] Deionized water 54g

[0056] Total 100g

[0057] Its preparation method is:

[0058] 1. Take 2g glyceryl monostearate, 10g acetylated monoglyceride, 5g glyceryl triacetate, 5g glyceryl capricate, 2g Luba gum oil, 6g OLIVEM1000, 5g polyoxyethylene (21 ) Put the stearyl ether in a 150ml beaker, heat it in a 65°C water bath, and stir to dissolve it completely, as the oil phase;

[0059] 2. Take a 150ml beaker, pour 3g of polyoxyethylene stearate, 3g of polyoxyethylene lauryl ether, and 54g of deionized water into the beaker, heat it in a 65°C water bath, and stir to make it evenly m...

Embodiment 3

[0064] The nanocarrier of loaded tetrahydrocurcumin, its formula is:

[0065] Tetrahydrocurcumin 5g

[0066] Glyceryl monostearate 2g

[0067] Acetylated Monoglycerides 10g

[0068] Glyceryl Triacetate 5g

[0069] Di-isooctyl sebacate 5g

[0070] Luba Gum Oil 2g

[0071] OLIVEM1000 6g

[0072] Polyoxyethylene (21) stearyl ether 8g

[0073] Laureth 3g

[0074] Deionized water 54g

[0075] Total 100g

[0076] Its preparation method is:

[0077] 1. Take 2g glyceryl monostearate, 10g acetylated monoglyceride, 5g triacetin, 5g diisooctyl sebacate, 2g Luba gum oil, 6g OLIVEM1000, 8g polyoxyethylene in the above formula (21) Put the stearyl ether in a 150ml beaker, heat it in a 65°C water bath, and stir to dissolve it completely, as the oil phase;

[0078] 2. Take a 150ml beaker, pour 3g of polyoxyethylene lauryl ether and 54g of deionized water into the beaker, heat in a 65°C water bath, and stir to mix evenly, as the water phase;

[0079] 3. Weigh 5g tetrahydrocurcumin an...

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PUM

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Abstract

The invention discloses a nano carrier loaded with tetrahydrocurcumin and a preparation method thereof. The key points of the preparation method are as follows: heating, melting and stirring evenly a composite lipid material and a water-in-oil emulsifying agent to obtain oil phase; then heating and evenly stirring the water-in-oil emulsifying agent and deionized water to obtain water phase; adding tetrahydrocurcumin into the oil phase and mixing evenly at a temperature of 50-70 DEG C; adding well stirred water phase into the oil phase mixture, heating and evenly stirring, cooling and solidifying to obtain the nano carrier loaded with tetrahydrocurcumin. The nano structured lipid carrier has good stability and compatibility; moreover, the bioavailability is relatively high, the preparation method is simple and controllable, and the repeatability is good. Therefore, the nano carrier can be well applied to the preparation of cosmetics containing curcumin.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and more specifically relates to a nanoscale carrier and a preparation method thereof. Background technique: [0002] Lipid nanoparticle technology is a nanoscale carrier system that uses highly physiologically compatible glyceride lipid materials as carrier materials and is prepared by modern nanotechnology and can be used to load active ingredients. Lipid nanoparticles have the following characteristics: 1. Possibility of realizing controllable drug release and targeted release; 2. Improved drug stability; 3. Higher drug loading; 4. Both lipophilic and hydrophilic drugs are convenient 5. The carrier has no biological toxicity; 6. The use of organic solvents is avoided; 7. Large-scale production and sterilization can be carried out. [0003] Tetrahydrocurcumin is a natural functional whitening raw material. It has a strong activity of inhib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/60A61K8/37A61K8/86A61K8/84A61K8/35A61Q19/02A61Q19/08
Inventor 夏强夏永昌
Owner 苏州纳康生物科技有限公司
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