Nano-carrier loaded with rhodiola rosea extract and preparation method and application thereof

Abstract

The invention relates to a nano-carrier loaded with a rhodiola rosea extract. The nano-carrier comprises the following components according to the weight ratio: 0.5% to 3% of rhodiola rosea extract, 20% to 30% of solvent, 40% to 50% of emulsifier and 18% to 35% of lipid material; the lipid material is a solid and liquid mixture of a liquid lipid material and a solid lipid material, and the emulsifier comprises a water-in-oil emulsifier and an oil-in-water emulsifier. A preparation method of the nano-carrier with the rhodiola rosea extract comprises the following steps: mixing the lipid material and the emulsifier as an oil phase; adding the water-in-oil emulsifier into the solvent as an internal aqueous phase; adding internal aqueous water into a liquid state oil phase; uniformly mixing and solidifying after being cooled to room temperature; adding the water-in-oil emulsifier, uniformly mixing to obtain a lipid system, solidifying after being cooled to room temperature to obtain the nano-carrier loaded with the rhodiola rosea extract. The invention has the following advantages: the nano-carrier loaded with the rhodiola rosea extract is jointly utilized with a technology of multiple emulsion and lipid nanoparticles, the traditional liquid state oil is replaced by the mixture of the solid state oil and the liquid state oil, the internal aqueous phase as the rhodiola rosea extract is more stable than the traditional multiple emulsion, and the obtained nano-carrier loaded with the rhodiola rosea extract as a material can be added into the cosmetics and foods, so that the existing application defects are effectively solved.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetics and food preparation technology, and relates to a preparation method of a nano-scale carrier, in particular to a nano-structured lipid carrier with rhodiola rosea extract as an active ingredient, its preparation method and application . Background technique [0002] Lipid Nanoparticles (LN) technology is a nanoscale carrier system that uses highly physiologically compatible glyceride lipid materials as carrier materials and is prepared by modern nanotechnology and can be used to load active ingredients. Lipid nanoparticles have the following characteristics: 1. Possibility of realizing controllable drug release and targeted release; 2. Improved drug stability; 3. Higher drug loading; 4. Both lipophilic and hydrophilic drugs are convenient 5. The carrier has no biological toxicity; 6. The use of organic solvents is avoided; 7. Large-scale production and sterilization can be ca...

AI Technical Summary

Problems solved by technology

However, there are bottlenecks in the current application process as follows: no sustained release function, active substances are easily oxidized, and low bioavailability

Images