An ultrasonic-pneumatic electrostatic nozzle comprises a spray rod with a tiny liquid flow channel processed in the axis, an ultrasonic generator, a nozzle air tap, a high-voltage electrostatic generator. The nozzle air tap surrounds the end of the spray rod to form the nozzle, a support device is arranged in the middle of the spray rod, the ultrasonic generator and the high-voltage electrostatic generator are pressed and fixed on one side face, away from the nozzle, of the support device through a fastening device, the ultrasonic generator is provided with a piezoelectric wafer, a backseat and a lead, the lead is connected to the piezoelectric wafer, short pulse of voltage acts on two poles of the piezoelectric wafer through the lead, the piezoelectric wafer elastically deforms so as to generate elastic oscillation, the high-voltage electrostatic generator is provided with an electrode to be connected with the liquid flow channel in the axis of the spray rod, and the high-voltage electrostatic generator applies high voltage static on liquid passing through the liquid flow channel of the spray rod. The nozzle is simple in structure, convenient to operate, safe and reliable, adjustable in spray flux and distance and the like, and is of great significance to spray effect improvement and reduction of chemical waste.