148 results about "Cerebral infarcts" patented technology

The novel amidino derivatives of the formula (I):wherein all the symbols are as in specification defined;have an inhibitory activity of a blood coagulation factor VIIa and are useful for treatment and / or prevention of several angiopathy caused by enhancing a coagulation activity, such as disseminated intravascular coagulation, coronary thrombosis, cerebral infarction, cerebral embolism, transient ischemic attack, cerebrovascular disorders, pulmonary vascular diseases, deep venous thrombosis, peripheral arterial obstruction, thrombosis after artificial vascular transplantation and artificial valve transplantation, post-operative thrombosis, reobstruction and restenosis after coronary artery bypass operation, reobstruction and restenosis after PTCA or PTCR, thrombosis by extracorporeal circulation and procoagulative diseases such as glomerlonephriitis.

The invention relates to a hydroxysaffloryellow A extracted from Chinese medicinal material safflower, a relative preparation method and application thereof. The inventive extraction method of hydroxysaffloryellow A is stuffed into chromatography column according to different diameter-height ratios, the invention uses the upper sample to process column chromatography according to different ratios between upper sample volumes and bed volumes, to separate and purify safflower extract. The invention has simple process, few steps, low cost, high yield, no environment pollution and suitability for industrialized and large-scale production. The yield of extracted hydroxysaffloryellow A is higher than 50%, while the hydroxysaffloryellow A content tested by high-effect liquid hydroxysaffloryellow A reaches 99.5%. The drug prepared from the hydroxysaffloryellow A can effectively prevent and treat cerebrovascular diseases as cerebral infraction and hypertensive cerebral hemorrhage or the like.

Intravenous administration of bone marrow cells collected from rat bone marrow to a rat cerebral infarction model was found to be effective in treating cerebral infarction. Human and murine bone marrow stem cells showed similar effects. Mesenchymal cells such as bone marrow cells, cord blood cells, or peripheral blood cells can be used as agents for in vivo administration against cranial nerve diseases.

The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a damaged part treatment method for repairing or restoring a damaged part of a target tissue that includes administering the damaged part treatment composition to a patient having the target tissue for the damaged part treatment composition in an amount therapeutically effective for repairing the damaged part of the target tissue; a method of treating cerebral infarction that includes administering the damaged part treatment composition to a cerebral infarct patient in an amount effective for repairing a damaged part of the brain; and a method of treating a CNS disease that includes administering, as a CNS disease treatment composition, the damaged part treatment composition to a CNS disease patient in a therapeutically effective amount.

It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) I2 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) I2 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and / or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.

The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification).The compounds of the formula (I) possess inhibitory activity of N-type calcium channel, so they are useful as drug for prevention and / or treatment of cerebral infarct, transient ischemic attack, encephalomyelopathy after cardiac operation, spinal angiopathy, hypertension with stress, neurosis, epilepsy, asthma and pollakiuria etc. or agent for the treatment of pain.

The invention relates to an ozagrel sodium injection and a preparation method thereof, in particular to an ozagrel sodium injection for treating acute thrombotic cerebral infarction and movement disorders concomitant with cerebral infarction, preferably injection solution and lyophilized powder injection. The ozagrel sodium injection mainly comprises ozagrel serving as an active component and sodium hydroxide and citric acid serving as auxiliary materials. Solvent in the injection solution is water for injection. Excipient in the lyophilized powder injection is mannitol and / or sorbitol which can be combined in any one or two optional medicinal proportions, or no excipient is added.

The invention discloses a PEGylated scutellarin compound and a preparation method thereof. The PEGylated scutellarin compound is as the shown formula (IV) and the PEGylated scutellarin compound can be applied to preparing medicaments applied to treating cerebral thrombosis, cerebral infarction, cerebral apoplexy, sequelaes caused by cerebral apoplexy, coronary heart disease or angina. Compared with the original scutellarin compound, the water solubility of the scutellarin compound is increased obviously; simultaneously, pharmacodynamics experiment on the mice model of cerebral ischemia-reperfusion shows that: compared with the original medicament, the biological activity of the scutellarin promedicament is strengthened obviously.

The invention provides a herba epimedii extract, in particular to a high-content herba epimedii total flavonoids extract, and the preparation method thereof mainly comprises the following steps: (1) alkali-ethanol-water is taken as a menstruum for refluxing extraction; (2) decompression and concentration are carried out; (3) pH value is adjusted; (4) macroporous resin column elution is carried out; and (5) an eluant is dried and the content of the obtained total flavonoids is over 65 percent and the content of icariin is over 20 percent. The extract can be prepared into various oral preparations according to the requirements in pharmacy, which can be hard capsules, soft capsules, conventional tablets, orally disintegrating tablets, buccal tablets, dispersible tablets, sustained-release preparations, controlled release preparations, granules, water-paste pills, dripping pills, honeyed pills, and the like. The extract and effective medicines containing the extract can be applied to preparing brain tissue protective agents, especially to preparing medicines that prevent and treat cerebral infarction, cerebral infarction sequela and other ischemic cerebrovascular diseases.

A magnetic resonance imaging white matter hyperintensities region recognizing method and system are disclosed herein. The white matter hyperintensities region recognizing method includes receiving and storing a FLAIR MRI image, a spin-lattice relaxation time weighted MRI image, and a diffusion weighted MRI image. Registration and fusion are preformed, and a white matter mask is determined. An intersection image of the FLAIR MRI image and the white matter mask is taken, a first region is determined after normalizing the intersection image, a cerebral infarct region is removed from the first image through the diffusion weighted MRI image, and then a determination is made as to whether to remove a remaining region in order to form a white matter hyperintensities region in the FLAIR MRI image.

The invention discloses a traditional Chinese medicinal preparation for treating the sequela of cerebral infarction. The traditional Chinese medicinal preparation is prepared from raw astragalus, salvia, angelica, chuanxiong, gastrodia, antelope horn, earthworm, cyathula, red peony, mulberry twig, saposhnikovia, ground pine, spatholobus, silkworm, typhonium, scorpion, pangolin scales, eucommia, agkistrodon, tortoise shell, lyceum, alpinia, turtle shell and licorice which are combined to generate a synergy to effectively nourish Yin and tonify kidney, expel wind, reduce phlegm, tonify Qi, invigorate blood circulation and remove blood stasis. In the traditional Chinese medicinal preparation, the astragalus, salvia, angelica and chuanxiong are used for tonifying Qi, invigorating blood circulation and removing blood stasis; the gastrodia, antelope horn and earthworm are used for reducing phlegm and extinguishing wind, and calming liver and suppressing Yang; and the tortoise shell and turtle shell are salty in flavor and cold in nature, return in the liver channel and have the effects of simultaneously nourishing Yin and suppressing Yang, and tonifying liver and kidney. The traditional Chinese medicinal preparation is used for treating the sequela of cerebral infarction, complied with the theories of traditional Chinese medicine and modern pharmacological study, and has the advantages of remarkable therapeutic effect and suitability for popularization and application.

The composition of Chinese medicine effective parts for treating cardiac and cerebral vascular diseases consists of general salvianolic acid and general astragalus saponin in certain ratio. The compound medicine has raised pharmacological effect and clinical curative effect and reduced impurity content. It may be prepared into various preparation forms. It is used in treating coronary heart disease, angina pectoris, myocardial ischemia, heart failure, arrhythmia, cerebral infarction and cerebral ischemia; and is safe, effective stable, controllable and convenient.

The invention discloses an oral preparation of ginkgo leaf total flavonoid aglycone, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total flavonoid glycosides extracted from ginkgo leaves are hydrolyzed to obtain ginkgo leaf total flavonoid aglycone which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the ginkgo leaf total flavonoid aglycone. The preparation has significant curative effects in the treatment of coronary disease, hyperpiesis, cerebral thrombosis, cerebral infarction, apoplexy, dizziness, psychosis, nephritis, bronchitis, Parkinson's disease, diabetes, tumor, leukemia and other diseases.

The present invention relates to the use of recombinant human kallidinogenase composition in preparing medicine for preventing and treating cerebral infarction. The recombinant human kallidinogenase composition is prepared with recombinant human kallidinogenase through combination with the host cell expressing the recombinant protein by means of molecular biology technology. It has obvious effect of preventing and treating cerebral infarction. The recombinant human kallidinogenase composition of the present invention is normally in the form of medicine composition, such as freeze dried powder for injection or liquid injection.

Drug compositions containing a substituted diamine compound represented by formula (1):Q1-Q2-r-N(R1)-Q3-N(R2)  (1)wherein Q3 represents the following groupwherein Q5 represents an alkylene group having 4 carbon atoms, R3 represents a hydrogen atom, and R4 represents a 3-6 membered heterocyclic group which may be substituted; are useful for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The invention relates to the field of medicaments, and in particular relates to a 3H-1,2-dithio-cyclopentene-3-thioketone compound and an application thereof. The 3H-1,2-dithio-cyclopentene-3-thioketone compound disclosed by the invention has a structure shown in a formula I or a formula II and is a compound with a completely-new structure. Proved by experiments, the 3H-1,2-dithio-cyclopentene-3-thioketone compound has a direct protection role on neurons on a cell model, and can obviously restrain excessive inflammatory responses of inflammatory cells in the cerebrum; and by using 3H-1,2-dithio-cyclopentene-3-thioketone, focal cerebral ischemia cerebral infarction volume of a mouse can be obviously reduced in an animal model. Therefore, the invention provides the 3H-1,2-dithio-cyclopentene-3-thioketone compound and the application of acceptable slat of the 3H-1,2-dithio-cyclopentene-3-thioketone compound on the pharmacy aspect to the preparation of medicaments for preventing or treating a cerebral apoplexy disease.

The invention relates to an effective part composite containing salvia miltiorrhiza bunge and panax pseudoginseng effective parts and a preparation method thereof and also relates to application of a drug prepared from the effective part composite in preventing and curing cardiovascular and cerebrovascular diseases, senile dementia, cerebral infarction, cerebral ischemia and other various diseases caused by cerebral ischemia, belonging to the technical field of traditional Chinese medicine. The composite comprises the following drug components in parts by weight: 10-99 parts of total salvianolic acid, 0-50 parts of tanshinone, 10-99 parts of panax notoginseng saponins, 0-50 parts of dalbergia wood general flavone and 0-20 parts of dalbergia wood oil total terpenoid. The effective part composite containing salvia miltiorrhiza bunge and panax pseudoginseng, which is disclosed by the invention, has better action of resisting myocardial ischemia, has certain action of resisting thrombopoiesis and anticoagulation, improves peroxide of cardiac muscular tissues during myocardial ischemia resistance, improves medical hemorheology and performs the efficacy of paths which affect clotting functions.

The present invention is thrombolytic composition for preventing and treating thrombus and its preparation process. Leech is extracted, salt separated and chromatographically separated to obtain leech extract; curcuma root and Chuanxiong rhizome are prepared into curcuma root and Chuanxiong rhizome extract through extraction and macroporous resin purification; and the leech extract and the curcuma root and Chuanxiong rhizome extract are merged to form the thrombolytic composition. The thrombolytic composition is further prepared into freeze dried powder for injection, injection, tablet, capsule or other preparation forms. The thrombolytic composition of the present invention has powerful thrombolytic effect, determined curative effect on cerebral infarction and myocardial infarction, etc., high safety, effect of preventing thrombosis and less toxic side effect.

The invention discloses a medicine for treating heart cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicine is prepared by ginseng, radix salviae miltiorrhizae and rhizoma ligustici wallichii according to a certain weight mixture ratio. The medicine can be prepared into any preparation which is pharmaceutically acceptable, preferably a dripping pill. The medicine has the functions of replenishing qi and invigorating blood circulation, is used for treating cardiovascular and cerebrovascular diseases, is particularly used for treating ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral ischemia, cerebral infarction, and the like, and is used for treating apoplexy, qi-deficiency, blood stasis syndromes, hemiplegia, orolingual deflection, aphasia and hypodynamia.

The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and / or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and / or treatment of cerebral infarction, particularly as an agent for the prophylaxis and / or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and / or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction.wherein the symbols are the same as defined in the description.

The invention relates to a method for establishing an artery ischemia model of a brain of a rhesus monkey and an evaluation method. The constructing method adopts the mode of directly puncturing femoral arteries of an experimental monkey to perform the intravascular interventional operation under the direct view of a digital subtraction angiography, and establishes the chronic cerebral infarctionprimate model by using a micro-catheter to block the arteries in the brain of the experimental monkey and controlling ischemia time. The model is a quite reasonable cerebral ischemia-reperfusion animal model, and the pathological characteristics of the monkey cerebral injury model established by the method are similar to clinical manifestation; and moreover, the model is stable and reliable and issuitable for all kinds of curing therapeutic research and related basic research.

The invention relates to a pharmaceutical composite, in particular to a pharmaceutical composite for treating cerebrovascular diseases and a preparation method thereof. The pharmaceutical composite is prepared from four active pharmaceutical ingredients of moschus, blumea camphor or borneol, turmeric essential oil and Cape jasmine fruit. The active ingredient of the Cape jasmine fruit in the pharmaceutical composite mainly comprises iridoid glycosides. Through pharmacological research, the result shows that the iridoid glycosides have extensive bioactivity and benefit cerebral nervous system and cardiovascular system. Through efficacy experiment, the result shows that the pharmaceutical composite has the obvious effects of alleviating the cerebral infarction of MCAT rat and improving the nervous syndrome.

The present invention provides agents for treating or preventing diseases such as mood disorder, anxiety disorder, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, alopecia, and so forth. Specifically, the invention provides azole derivatives represented by general formula (I), or pharmaceutically acceptable salts thereof that have an antagonistic action against the arginine-vasopressin (AVP) V1b receptor:

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases and a preparation method of the medicament. The medicament is prepared from a ginseng extract, a red-rooted salvia root extract and a hemlock parsley extract according to a certain weight proportion, wherein the ginseng extract, the red-rooted salvia root and the hemlock parsley extract can be obtained by commercial way or extracted from medicinal materials. The medicament can be prepared to form any pharmaceutically acceptable dosage form, preferably drop pills. The medicament has effects of tonifying qi and activating blood circulation, can be used for treating cardiovascular and cerebrovascular diseases, in particular treating in acute and early recovery phase of cerebral thrombosis, cerebral ischemia, cerebral infarction and other ischemic cerebrovascular diseases.

The invention relates to a new medicinal preparation of a medicinal intelligent medicine release system, belongs to the biological medicine field, and concretely relates to a sudden death and hypertension resistant metoprolol intelligent medicine release system and its preparation method. The metoprolol intelligent medicine delivery system is characterized in that the metoprolol intelligent medicine release system is formed by a main controlled release layer (a tablet core, a pill core or a pellet), and the external of the main controlled release layer is coated with an intelligent film coat. Medicine release is carried out according to the human blood pressure rhythm 3-6h after the preparation is orally taken, simultaneously the main controlled release layer slowly releases medicines according to a preset medicine release speed, the highest plasma medicine concentration lasts for 10-16h, and the medicine performs the curative effect within 24h. The preparation can control the cardiogenic sudden death, the cerebral hemorrhage, the cerebral infarction and the like caused by the physiological change of the human blood pressure and the heart rate after midnight, and has very good clinical application prospects.

The invention relates to a peony seed oil gel candy and a preparation method thereof. The peony seed oil gel candy is prepared from peony seed oil, gelatin, glycerol and mannitol as raw materials through proper weight proportioning so as to finally obtain the gel candy which has the effects of regulating blood sugar, blood fat and blood pressure and preventing myocardial infarction and cerebral infarction. The preparation method of the peony seed oil gel candy has the advantages of short time, low energy consumption, large treatment capacity of medicinal raw materials, less impurities, sufficient extraction of effective ingredients of the raw materials, high extraction rate, simple extraction process operation, low cost and remarkable comprehensive economic benefits. In addition, the peonyseed oil gel candy is low in calorie, fragrant and sweet in taste, simple and stable in formula and convenient to eat and carry.

The invention provides a traditional Chinese medicine composition, which consists of raw materials in the following weight portion: hirudo, gadfly, eupolyphaga, angelica, radix paeoniae rubra, ginseng, radix astragali, peach kernel, oyster, semen vaccariae, radix curcumae, rhizoma corydalis, radix bistortae, amomum fruit, and angelica dahurica. The invention also provides a traditional Chinese medicine preparation containing the composition and a method for preparing the same. The traditional Chinese medicine composition and the traditional Chinese medicine preparation are mainly used for treating cerebral apoplexy, cerebral infarction or cerebral tumor which is distinguished to belong to Qi-deficiency and blood stasis syndrome by the traditional Chinese medical science.

The invention belongs to the field of medicines, relates to application of a physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract for treating cerebral ischemia and cerebral infarction, and in particular relates to tablets, capsules, pills and other clinical common medicinal preparations and controlled-release preparations prepared by using physalis alkekengi L.var.franchetii (Mast.) Makino total saponins as a raw material. Animal experiments indicate that the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins can be used for remarkably improving behavioral symptoms caused by cerebral ischemia of a rat, reducing the size of cerebral infarction, and reducing rat encephaledema destructed by cerebral ischemia. According to the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract, the novel application of physalis alkekengi L.var.franchetii (Mast.) Makino total saponins is expanded, and a new medical resource is provided to prevention and treatment of cerebral ischemia and cerebral infarction.

The compound Chinese medicine preparation consists of general salviandic acid extracted from danshen and general arasaponin extracted from notoginseng in certain proportion. In has the same pharmaceutical function and clinical effect as traditional Chinese medicine and less impurity content. It may be prepared into various preparation forms for treating cerebral infarction, cerebral ischemia, coronary heart disease, angina pectoris, myocardial infarction, etc. The present invention is one safety, effective, stable, controllable and convenient compound Chinese medicine preparation.

The invention discloses the application of cerebroside B which is extracted and prepared from termitomyces in preparing a medicine for treating ischemic brain injury. The application proves that a cerebroside compound has obvious treatment function on ischemic brain injury through pharmacology experiments, can reduce the cerebral infarction area which is caused by cerebral ischemia and relieve the cerebral edema through a blood-brain barrier, reduce the death of nerve cells, and simultaneously promote recovery of movement and cognitive functions after cerebral apoplexy, so the death rate of the cerebral apoplexy is reduced. The application develops the new medicine application of the cerebroside compound, and new therapeutic drugs are provided for treating diseases of the cerebral apoplexy.