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Epimedium extract and preparation method, preparation and use thereof

An epimedium extract and extract technology, which can be used in pill delivery, drug combination, pharmaceutical formula, etc., can solve the problems of not getting the expected effect, and achieve the effects of improving nerve dysfunction, reducing vascular resistance, and increasing energy

Inactive Publication Date: 2009-04-29
南京宇道科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor has carried out a large number of repeated experiments according to the preparation methods described in various reports in the process of trying to obtain high-content epimedium extracts, but the expected results have not been obtained according to the methods described therein. Effect

Method used

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  • Epimedium extract and preparation method, preparation and use thereof
  • Epimedium extract and preparation method, preparation and use thereof
  • Epimedium extract and preparation method, preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0231] Example 1: Preparation method of Epimedium extract:

[0232] Weigh 40kg of Epimedium, add about 800L of 0.01% sodium carbonate and 50% ethanol, reflux for 2 hours, then filter, continue to use 0.01% sodium carbonate and 50% ethanol for about 800L of filter residue, reflux for 2 hours, filter, repeat once more, combine three times filtrate. The filtrate was concentrated under reduced pressure at 65°C to a relative density of about 1.15 to 1.20, filtered while hot, the filtrate was adjusted to neutral pH with dilute hydrochloric acid, and passed through a pre-treated HPD100 macroporous adsorption resin column, followed by water and 30% ethanol , 60% ethanol elution, collect the 60% ethanol eluate, recover the ethanol, concentrate under reduced pressure at 70°C to a thick paste with a relative density of 1.30~1.35 (60°C), vacuum dry, and crush to obtain Epimedium extract Things.

Embodiment 2

[0233] Example 2: Hard capsules

[0234] Prescription (1000 capsules):

[0235] Epimedium extract 100g

[0236] Microcrystalline cellulose 150g

[0237] The epimedium extract is mixed with microcrystalline cellulose, sieved to make it evenly mixed, and an appropriate amount of water or ethanol of a suitable concentration is added for granulation, after drying, the granules are sizing and the capsules are filled.

Embodiment 3

[0238] Example 3 Tablets

[0239] Epimedium extract 10~400mg / cap

[0240] Sodium carboxymethyl starch 4~12mg / grain

[0241] Magnesium stearate 0.1~0.3mg / tablet

[0242] Starch 50~600mg / grain

[0243] Sieving the total flavonoids of Epimedium, mixed with sodium carboxymethyl starch and lactose, sieving, adding proper amount of water or proper concentration of ethanol to granulate, after drying, whole granules, adding proper amount of magnesium stearate, using appropriate The punching device presses the tablets. Tablets of different strengths can be prepared by changing the ratio of the active ingredient to the carrier or by changing the compressed weight.

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Abstract

The invention provides a herba epimedii extract, in particular to a high-content herba epimedii total flavonoids extract, and the preparation method thereof mainly comprises the following steps: (1) alkali-ethanol-water is taken as a menstruum for refluxing extraction; (2) decompression and concentration are carried out; (3) pH value is adjusted; (4) macroporous resin column elution is carried out; and (5) an eluant is dried and the content of the obtained total flavonoids is over 65 percent and the content of icariin is over 20 percent. The extract can be prepared into various oral preparations according to the requirements in pharmacy, which can be hard capsules, soft capsules, conventional tablets, orally disintegrating tablets, buccal tablets, dispersible tablets, sustained-release preparations, controlled release preparations, granules, water-paste pills, dripping pills, honeyed pills, and the like. The extract and effective medicines containing the extract can be applied to preparing brain tissue protective agents, especially to preparing medicines that prevent and treat cerebral infarction, cerebral infarction sequela and other ischemic cerebrovascular diseases.

Description

Technical areas: [0001] The present invention relates to the field of traditional Chinese medicine development, in particular to an epimedium extract and its preparation method, preparation and application in preparing brain tissue protective agents, especially in the prevention and treatment of ischemia such as cerebral infarction and cerebral infarction sequelae. Application in drugs for chronic cerebrovascular diseases. Background technique: [0002] Cerebral infarction is commonly known as stroke or stroke. Stroke is divided into hemorrhagic stroke and ischemic stroke. Ischemic stroke is cerebral infarction, which includes cerebral thrombosis, cerebral embolism, etc. Cerebral infarction accounts for 70% to 80% of all strokes, and has increased significantly in recent years, and Develop towards younger people. Some patients are only 27 years old, but most are middle-aged and elderly people over 45 years old. The main pathological change of cerebral infarction is based ...

Claims

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Application Information

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IPC IPC(8): A61K36/296A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 阮锦满史美耿石海云王永毅钱世祥王燕萍朱静娟
Owner 南京宇道科技开发有限公司
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