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Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof

A technology of hydroxysafflower and yellow pigment, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of no practical application value, small yield, unfavorable large-scale production, etc., and achieve shortening Production cycle, improved purity, grainy and crispy effect

Active Publication Date: 2008-06-11
山西德元堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a small yield is not conducive to large-scale industrial production and has no practical application value
[0007] Visible, there is no preparation method based on the higher hydroxysafflower yellow A of yield at present, and can guarantee the higher purity of the prepared hydroxysafflower yellow A at the same time

Method used

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  • Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof
  • Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof
  • Hydroxyl carthamus tinctorius yellow colour A, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] [Example 1] Preparation of hydroxy safflower yellow A

[0036] 1) Extraction: Take 100g of safflower medicinal material, add 1200g of water and extract at 80°C for 3 times, each time for 1.5 hours, combine the extracts, concentrate to a relative density of 1.12 at 60°C, let stand for 24 hours and then centrifuge to get the supernatant ;

[0037] 2) Separation: Take the supernatant, add it to the treated D101 macroporous adsorption resin column with a bed diameter-to-height ratio of 1:10 according to the ratio of the volume of the supernatant to the column bed volume of 1:10, Elute with water at a flow rate of 20ml / min until the eluent Molisch reaction and ninhydrin reaction are negative, then use 5% ethanol solution of 5 column bed volumes to elute at a flow rate of 20ml / min, and collect 5% ethanol for elution solution, concentrated to a relative density of 1.2 at 50°C to obtain concentrated solution A;

[0038] 3) Purification: Take the concentrated solution A and ad...

preparation Embodiment 1

[0049] [Formulation Example 1] Hydroxysafflower yellow A freeze-dried powder injection

[0050] Hydroxysafflower Yellow A 25g

[0051] Mannitol 25g

[0052] Add water for injection to 400ml

[0053] Weigh the dry powder of hydroxysafflower yellow A and mannitol respectively, add water for injection to dissolve and add water for injection to the full amount, stir well, filter aseptically, divide the filtrate into vials, 0.4ml per bottle, vacuum freeze-dry , Press the plug and seal the aluminum cover. Hydroxysafflower yellow A freeze-dried powder injection was prepared.

preparation Embodiment 2

[0054] [Formulation Example 2] Hydroxysafflower yellow A freeze-dried powder injection

[0055] Hydroxysafflower Yellow A 25g

[0056] Mannitol 50g

[0057] Add water for injection to 800ml

[0058] Weigh the dry hydroxysafflower yellow A powder and mannitol respectively, add water for injection to dissolve and add water for injection to the full amount, stir well, filter aseptically, divide the filtrate into vials, 0.8ml per bottle, vacuum freeze-dry , Press the plug and seal the aluminum cover. Hydroxysafflower yellow A freeze-dried powder injection was prepared.

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PUM

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Abstract

The invention relates to a hydroxysaffloryellow A extracted from Chinese medicinal material safflower, a relative preparation method and application thereof. The inventive extraction method of hydroxysaffloryellow A is stuffed into chromatography column according to different diameter-height ratios, the invention uses the upper sample to process column chromatography according to different ratios between upper sample volumes and bed volumes, to separate and purify safflower extract. The invention has simple process, few steps, low cost, high yield, no environment pollution and suitability for industrialized and large-scale production. The yield of extracted hydroxysaffloryellow A is higher than 50%, while the hydroxysaffloryellow A content tested by high-effect liquid hydroxysaffloryellow A reaches 99.5%. The drug prepared from the hydroxysaffloryellow A can effectively prevent and treat cerebrovascular diseases as cerebral infraction and hypertensive cerebral hemorrhage or the like.

Description

technical field [0001] The invention relates to hydroxysafflower yellow A extracted from traditional Chinese medicine safflower, its preparation method and application. Background technique [0002] Safflower is the dried flower of Carthamus tinctorius L., a plant in the Compositae family. It has a pungent and warm nature, enters the heart and liver meridians, and has the effect of removing blood stasis and relieving pain. It is the king drug of various prescriptions for promoting blood circulation and removing blood stasis. The extraction of active ingredients in safflower has attracted more and more attention from relevant people. Previous studies have shown that the active ingredients of safflower for promoting blood circulation are mainly concentrated in water-soluble safflower yellow pigment. Safflower yellow is a chalcone compound, which has various pharmacological effects such as expanding coronary artery, anti-oxidation, protecting myocardium, lowering blood pressure...

Claims

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Application Information

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IPC IPC(8): C07H15/20A61K31/7034A61K36/286A61P9/00
Inventor 杨炜
Owner 山西德元堂药业有限公司
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