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Medicine for treating heart cardiovascular and cerebrovascular diseases and preparation method thereof

A technology of drugs and medicinal materials, applied in the field of traditional Chinese medicine, can solve problems such as high cost and instability

Inactive Publication Date: 2009-12-02
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for oral preparations, the cost of using Ligustrazine is relatively high, and the oral dosage form enters the human body through the digestive system, so the requirements for the components are relatively low. Incorporate more active ingredients into the drug (although these ingredients may be unstable for injectable formulations)

Method used

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  • Medicine for treating heart cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Ginseng 100g

[0042] Danshen 500g

[0043] Chuanxiong 500g

[0044] Take ginseng, salvia miltiorrhiza, and Chuanxiong medicinal materials, add 8 times the amount of water to decoct 3 times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoctions, filter, concentrate the filtrate, and use ethanol precipitation for 2 times, The first time the alcohol content reaches 75%, the second time the alcohol content reaches 85%, each time after adding ethanol, place it in cold storage, filter, combine the filtrate, concentrate under reduced pressure, and dry under reduced pressure to obtain the active ingredient;

[0045] Heat and melt 1320g of polyethylene glycol 4000, add the above active ingredients, mix well, keep warm at 60-80°C, drop into the cooled simethicone, take out the dropping pills after cooling, drain and wipe off the simethicone, that is Got drop pills.

Embodiment 2

[0047] Ginseng 300g

[0048] Danshen 1000g

[0049] Chuanxiong 300g

[0050] Take ginseng, salvia miltiorrhiza, and Chuanxiong medicinal materials, add 10 times the amount of water to decoct 3 times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoctions, filter, concentrate the filtrate, and use ethanol precipitation for 2 times. The first time the alcohol content reaches 75%, the second time the alcohol content reaches 85%, each time after adding ethanol, place it in cold storage, filter, combine the filtrate, concentrate under reduced pressure, and dry under reduced pressure to obtain the active ingredient;

[0051] Heat and melt 1920g of polyethylene glycol 6000, add the above active ingredients, mix well, keep warm at 60-80°C, drop into the cooled liquid paraffin, take out after the dropping pills are cooled, drain and wipe off the liquid paraffin, and you get the drop pill pill.

Embodiment 3

[0053] Ginseng 200g

[0054] Danshen 500g

[0055] Chuanxiong 1000g

[0056] Take ginseng, salvia miltiorrhiza, and Chuanxiong medicinal materials, add 12 times the amount of water to decoct 3 times, the first time for 2 hours, the second and third times for 1.5 hours each, combine the decoctions, filter, concentrate the filtrate, and use ethanol precipitation treatment twice, The first time the alcohol content reaches 75%, the second time the alcohol content reaches 85%, each time after adding ethanol, place it in cold storage, filter, combine the filtrate, concentrate under reduced pressure, and dry under reduced pressure to obtain the active ingredient;

[0057] Heat and melt 2040g PEG4000, add active ingredients, mix well, keep warm at 60-80°C, drop into the cooled simethicone, take out the dropping pills after cooling, drain and wipe off the simethicone to get the dropping pills.

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Abstract

The invention discloses a medicine for treating heart cardiovascular and cerebrovascular diseases and a preparation method thereof. The medicine is prepared by ginseng, radix salviae miltiorrhizae and rhizoma ligustici wallichii according to a certain weight mixture ratio. The medicine can be prepared into any preparation which is pharmaceutically acceptable, preferably a dripping pill. The medicine has the functions of replenishing qi and invigorating blood circulation, is used for treating cardiovascular and cerebrovascular diseases, is particularly used for treating ischemic cerebrovascular diseases, such as cerebral thrombosis, cerebral ischemia, cerebral infarction, and the like, and is used for treating apoplexy, qi-deficiency, blood stasis syndromes, hemiplegia, orolingual deflection, aphasia and hypodynamia.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, especially for treating ischemic encephalopathy, and belongs to the field of traditional Chinese medicine. Background technique [0002] Cerebral ischemia, also known as ischemic stroke and cerebral infarction, is a type of disease caused by ischemia and hypoxia caused by cerebral blood flow disorder, resulting in localized brain necrosis or encephalomalacia. Ischemic brain injury includes primary injury during the ischemic period and secondary injury during the reperfusion period. The initial link in the pathological process is ischemia, and the restoration of blood perfusion in the brain tissue is the basis of its treatment, but the subsequent reperfusion Perfusion injury is inevitable. Cerebral ischemia-reperfusion injury refers to the phenomenon that brain cells are damaged due to cerebral ischemia, and the ischemic injury...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/20A61P7/02A61P9/10
Inventor 张保献胡杰
Owner BEIJING INCREASEPHARM CORP LTD
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