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Oral medicinal preparation of ginkgo leaf total flavonoid aglycone, preparation method and an application thereof

A technology of total flavonoid aglycones and total flavonoid glycosides, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical raw materials derived from Ginkgo biloba.

Inactive Publication Date: 2009-09-02
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing technology has neglected the research on the curative effect and preparation of the total flavonoid aglycone of Ginkgo biloba, and its effect and application have been in a blank state.

Method used

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  • Oral medicinal preparation of ginkgo leaf total flavonoid aglycone, preparation method and an application thereof
  • Oral medicinal preparation of ginkgo leaf total flavonoid aglycone, preparation method and an application thereof
  • Oral medicinal preparation of ginkgo leaf total flavonoid aglycone, preparation method and an application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Take 100g of total flavonoid aglycone of ginkgo leaves, add chitosan 20g, polyvinylpyrrolidone 20g, carbomer 10g, poloxamer 50g, lecithin 50g, micropowder silica gel 50g, beta cyclodextrin 100g, starch 100g, vibrate Grinding and superfine pulverization and mixing for 30 minutes, subpackaging to make powder.

Embodiment 2

[0123] Take 70g of total flavonoid aglycone of ginkgo leaf and 10g of total flavonoid aglycone of pueraria root, add chitosan 5g, carbomer 5g, poloxamer 14g, lecithin 10g, micronized silica gel 10g, beta cyclodextrin 20g, carboxymethyl Starch sodium 6g, microcrystalline cellulose 50g, heavy-pressure grinding supermicrocomputer ultrafine pulverization for 30 minutes, adding 70% ethanol to combine for 10 minutes, making pellets, grading and rounding, drying, polishing, sub-packaging, and making Form into pills.

Embodiment 3

[0125] Take 80g of total ginkgo leaf flavonoid aglycone and 40g of ginkgo leaf total lactones, add 2g of chitosan, 10g of lecithin, 66g of dextrin, 2g of aspartame, stir evenly, dry press granules, pack separately, and make Granules.

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Abstract

The invention discloses an oral preparation of ginkgo leaf total flavonoid aglycone, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total flavonoid glycosides extracted from ginkgo leaves are hydrolyzed to obtain ginkgo leaf total flavonoid aglycone which is then added with special auxiliary materials for preparing a highly efficient preparation, thereby greatly increasing the bioavailability of the ginkgo leaf total flavonoid aglycone. The preparation has significant curative effects in the treatment of coronary disease, hyperpiesis, cerebral thrombosis, cerebral infarction, apoplexy, dizziness, psychosis, nephritis, bronchitis, Parkinson's disease, diabetes, tumor, leukemia and other diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine ginkgo leaf extract, in particular to an extract of ginkgo leaf total flavonoid aglycone, and the medicinal use of the extract. It belongs to the field of traditional Chinese medicine. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba L. Ginkgo biloba originates in my country, and exists in places such as Tianmu Mountain and Dabie Mountain in Zhejiang Province as wild species. Because the base wood maintains the ecological characteristics of 150 million years ago, it is also called "living fossil" plant. Ginkgo biloba tastes sweet and bitter, astringent and flat in nature. It can improve intelligence and prolong life, beautify skin and hair care, restrain lung and relieve asthma, reduce astringency and relieve belt. Indications for senile neurasthenia, heartache, chest tightness, dyspnea and cough, leucorrhea, diarrhea, etc. Ginkgo biloba flavonoids have unique physiolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61K9/20A61K9/48A61K47/32A61K47/36A61K47/34A61K47/40A61P1/08A61P3/10A61P7/02A61P9/10A61P11/00A61P13/12A61P25/00A61P25/16A61P35/00A61K127/00A61K47/10A61K47/24A61K47/44
Inventor 李钦青张佳余
Owner 北京凯瑞创新医药科技有限公司
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