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Physalis alkekengi L.var.franchetii (Mast.) Makino total saponin extract for treating cerebral ischemia and cerebral infarction

A technology for extracting and total saponins, which is used in the field of cerebral infarction.

Inactive Publication Date: 2014-04-02
QIQIHAR UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Before the present invention, there was no report on the pharmacological activity of total saponins of calyx clover in preventing and treating cerebral ischemia and cerebral infarction

Method used

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  • Physalis alkekengi L.var.franchetii (Mast.) Makino total saponin extract for treating cerebral ischemia and cerebral infarction
  • Physalis alkekengi L.var.franchetii (Mast.) Makino total saponin extract for treating cerebral ischemia and cerebral infarction
  • Physalis alkekengi L.var.franchetii (Mast.) Makino total saponin extract for treating cerebral ischemia and cerebral infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Calyx clover saponins dispersible tablets

[0059] 【prescription】

[0060] Calyx clover saponins extract 150g

[0061] Disintegrant or swelling excipient 95g

[0062] Polyvinylpyrrolidone (K30) 10.4g

[0063] Sodium cetyl sulfosuccinate 0.4g

[0064] Magnesium Stearate 5g

[0065] [Preparation process] Take 300g of total saponins extract of Calyx clover with a powder diameter of 11.6μm and 190g of disintegrating agent and mix them in a mixer; add 20.8g of polyvinylpyrrolidone and 0.8g of sodium cetyl sulfosuccinate 200ml of ethanol: water (1:1) solution, make soft material, sieve and granulate; dry in a bed at 70°C for 20min; add 10g of magnesium stearate that has passed through a 125μm aperture sieve in advance, mix; place on a tablet machine Compressed into tablets of 200 mg each.

Embodiment 2

[0066] Example 2: Lyophilized Tablets of Total Saponins of Calyx clover

[0067] 【prescription】

[0068] Ingredients dosage per tablet / mg

[0069] Calyx calyx saponins extract 50

[0070] Peppermint essence amount

[0071] Gelatin 85

[0072] Tartaric acid 5

[0073] Mannitol 100

[0074] appropriate amount of lemon yellow

[0075] Xanthan Gum 3

[0076] Aspartame 0.1

[0077] Add water to 2ml

[0078] [Preparation process] Make gelatin, mannitol, xanthan gum, and tartaric acid into paste with appropriate amount of water, add coloring agent and mix well; add total saponin extract of Calyx clover calyx, add appropriate amount of water to make a uniform suspension , add flavoring agent and flavoring agent, mix well, add water to the full amount, stir evenly, divide into round tanks made of polyvinyl chloride, the diameter of the round tanks is 12mm; finally freeze-dry to get the product.

Embodiment 3

[0079] Example 3: Intragastric Floating Controlled Release Tablets

[0080] 【prescription】

[0081] Prescription raw materials per tablet content

[0082] Calyx clover saponins extract 300mg

[0083] Lactose (dried) 68mg

[0084] Mannitol 24mg

[0085] Sodium hydroxymethylcellulose 93mg

[0086] Hydroxypropyl Methyl Cellulose 55mg

[0087] Polyvinylpyrrolidone 15mg

[0088] Methylcellulose 63.6mg

[0089] Glyceryl monostearate 29.4mg

[0090] Talc 8 mg

[0091] Magnesium Stearate 4mg

[0092] [Preparation process] The above raw and auxiliary materials are crushed, passed through a No. 6 sieve, mixed, and the powder is directly compressed into tablets.

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Abstract

The invention belongs to the field of medicines, relates to application of a physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract for treating cerebral ischemia and cerebral infarction, and in particular relates to tablets, capsules, pills and other clinical common medicinal preparations and controlled-release preparations prepared by using physalis alkekengi L.var.franchetii (Mast.) Makino total saponins as a raw material. Animal experiments indicate that the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins can be used for remarkably improving behavioral symptoms caused by cerebral ischemia of a rat, reducing the size of cerebral infarction, and reducing rat encephaledema destructed by cerebral ischemia. According to the physalis alkekengi L.var.franchetii (Mast.) Makino total saponins extract, the novel application of physalis alkekengi L.var.franchetii (Mast.) Makino total saponins is expanded, and a new medical resource is provided to prevention and treatment of cerebral ischemia and cerebral infarction.

Description

technical field [0001] The invention belongs to the field of medicaments, and relates to the application of total saponin extract of calyx clover to prevent and treat cerebral ischemia and cerebral infarction. Background technique [0002] Cerebral ischemia and cerebral infarction are one of the major diseases that endanger human health. The mild ones are disabled, and the severe ones are fatal, especially for the elderly. With the arrival of my country's aging society, it will seriously affect the health of the elderly in our country, even their lives, and directly or indirectly cause huge economic losses and significant social impacts. Therefore, the prevention and treatment of cerebral ischemia and cerebral infarction have become the focus of research in China and even in the world. It has been found that there are some medicines for the prevention and treatment of cerebral ischemia and cerebral infarction, but the prevention effect is better but the treatment effect is ...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/20A61P9/10
Inventor 马舒伟刘兴艳赵明梁军刘红霞
Owner QIQIHAR UNIVERSITY
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