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Pharmaceutical composition for treating and preventing thrombus and its preparation method

A composition and technology for thrombosis, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of inconvenient use, low drug utilization rate, uncontrollable quality, etc., and achieve less toxic and side effects, The effect of exact curative effect and feasible process

Inactive Publication Date: 2006-06-21
广东仁泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] If the prescription is directly administered with medicinal materials, it is inconvenient to use, the utilization rate of the drug is low, the curative effect cannot be guaranteed, and the quality cannot be controlled.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of leech extract

[0029] Take 15kg of leech and crush it into a coarse powder, add 50L of 70% medicinal ethanol, soak and extract at 60°C for 1.5h, filter, add 50L of 70% medicinal ethanol to the dregs, soak at 60°C for 1.5h, filter, The two filtrates were combined. The pretreated macroporous adsorption resin on the filtrate is eluted with 75% ethanol. After the eluate is concentrated, it is ultrafiltered with an ultrafiltration column to cut off a solution with a molecular weight of 3000-20000. The ultrafiltrate is concentrated under reduced pressure and dried at low temperature to obtain Leech extract, weighing 37.3g. Batch number: 040201

Embodiment 2

[0030] Embodiment 2: the preparation of leech extract

[0031] Take 15kg of leeches and crush them into coarse powder, add 50L of 90% medicinal ethanol, soak and extract at 60°C for 1.5h, filter, add 50L of 90% medicinal ethanol to the dregs, soak at 60°C for 1.5h, filter, The two filtrates were combined. The pretreated chromatographic column on the filtrate is eluted with 75% ethanol. After the eluate is concentrated, it is ultrafiltered with an ultrafiltration column to cut off a solution with a molecular weight of 5000-20000. The ultrafiltrate is concentrated under reduced pressure and dried at low temperature to obtain leech Extract, weighing 35.2g. Batch number: 040211

[0032] Determination of the content of hirudin:

[0033] Take 0.25g of fibrinogen and dissolve it in 50mL of Tris2HCl buffer (pH=8) to obtain a 0.5% fibrinogen solution. "Dilute thrombin to 5NIH / mL" Take 0.2mL of fibrinogen solution and add 20μL of leeches Extract solution (respectively take 040201 an...

Embodiment 3

[0036] Embodiment 3: the preparation of turmeric and Chuanxiong extract

[0037] Take 20kg of turmeric and 30kg of Ligusticum chuanxiong to make coarse powder, extract three times with 75% ethanol, 300L each time, combine the extracts and concentrate to a relative density of 1.18 (50°C), add 6 times the amount of water to fully stir, and refrigerate for 24 hours in a cold storage , after filtering, apply ADS-5 macroporous adsorption resin (Tianjin Orui Biological Technology Co., Ltd.), and the eluent is concentrated and dried to obtain the extract of turmeric and Chuanxiong, weighing 88.7g. Batch number: 040220

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PUM

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Abstract

The present invention is thrombolytic composition for preventing and treating thrombus and its preparation process. Leech is extracted, salt separated and chromatographically separated to obtain leech extract; curcuma root and Chuanxiong rhizome are prepared into curcuma root and Chuanxiong rhizome extract through extraction and macroporous resin purification; and the leech extract and the curcuma root and Chuanxiong rhizome extract are merged to form the thrombolytic composition. The thrombolytic composition is further prepared into freeze dried powder for injection, injection, tablet, capsule or other preparation forms. The thrombolytic composition of the present invention has powerful thrombolytic effect, determined curative effect on cerebral infarction and myocardial infarction, etc., high safety, effect of preventing thrombosis and less toxic side effect.

Description

Technical field: [0001] The invention relates to a thrombolytic drug composition for treating and preventing thrombosis and a preparation method thereof Background technique: [0002] Thrombotic disease is a kind of disease that seriously endangers human health and life. It includes many common and frequently-occurring diseases such as coronary heart disease, myocardial infarction, ischemic stroke, venous thrombosis and pulmonary thromboembolism. The rate and death rate are high. my country's traditional Chinese medicine culture is extensive and profound, and traditional prescriptions are a treasure house for new drug development, from which it is of great significance to develop new drugs for the treatment and prevention of thrombosis. Xueshuanjie is an ancient prescription composed of leeches, turmeric and Chuanxiong. It is used to dispel blood stasis and stimulate menstruation. It is mainly used to treat partial dryness, disturbance of consciousness, hemiplegia, crooked ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K35/62A61P7/02A61P9/10
Inventor 王伟刘二伟
Owner 广东仁泰药业有限公司
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