Preparation technology and purpose of citrus grandis peel flavones

A technology for flavonoids from grapefruit peel and a preparation process is applied in the field of preparation technology of flavonoids from grapefruit peel to achieve the effects of enhancing cardiovascular function, reducing blood lipids and improving utilization rate

Inactive Publication Date: 2012-01-04
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on whether citrus flavonoids (Pure Total Flavonoids Citrus, PTFC) can regulate the oxidative stress caused by lipid metabolism disorders caused by hyperlipidemia and high-fat diet

Method used

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  • Preparation technology and purpose of citrus grandis peel flavones
  • Preparation technology and purpose of citrus grandis peel flavones
  • Preparation technology and purpose of citrus grandis peel flavones

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The preparation technology of citrus peel flavonoids, described preparation technology comprises the steps:

[0061] (1) Pretreatment: Sorting and cleaning the pomelo, then separating the peel and pulp of the pomelo after cleaning, taking the fresh ripe pericarp and cutting it into shreds for later use;

[0062] (2) Extraction: Accurately weigh 500g of shredded pomelo peel, add 6 times of ethanol solution to the peel, soak for 0.5 hour, heat to boiling, extract twice, each time the extraction interval is 30min to obtain the extract, the ethanol The mass concentration is 25%;

[0063] (3) Concentration: the extract is concentrated under reduced pressure at a temperature of 40°C and a vacuum of -0.08Mpa, concentrated to 40% of the original volume of the concentrated solution, and the concentrated solution is added with ethanol with a mass concentration of 92% and allowed to stand 12 hours of primary alcohol precipitation, the volume ratio of the concentrated solution to ...

Embodiment 2

[0069] The preparation technology of citrus peel flavonoids, described preparation technology comprises the steps:

[0070] (1) Pretreatment: Sorting and cleaning the pomelo, then separating the peel and pulp of the pomelo after cleaning, taking the fresh ripe pericarp and cutting it into shreds for later use;

[0071] (2) Extraction: Accurately weigh 500 g of pomelo peel, add 10 times of ethanol solution to the peel, soak for 1.5 hours, heat to boiling, extract 3 times, each extraction interval is 30min to obtain the extract, the ethanol The mass concentration is 50%;

[0072] (3) Concentration: the extract is concentrated under reduced pressure at a temperature of 50°C and a vacuum of -0.06Mpa, and concentrated to 50% of the original volume to obtain a concentrated solution. Adding mass concentration to the concentrated solution is 94% edible ethanol and statically Place the primary alcohol precipitation for 16 hours, the volume ratio of the concentrated solution to edible ...

Embodiment 3

[0080] The preparation technology of citrus peel flavonoids, described preparation technology comprises the steps:

[0081] (1) Pre-treatment: sorting and cleaning the pomelo, and then separating the peel and pulp of the pomelo after cleaning, and taking fresh ripe pericarp for later use;

[0082] (2) Extraction: Accurately weigh 500 g of pomelo peel, add 16 times of ethanol solution to the peel, soak for 3 hours, heat to boiling, extract 3 times, each extraction interval is 48min to obtain the extract, the ethanol The mass concentration is 60%;

[0083] (3) Concentration: the extract is concentrated under reduced pressure at a temperature of 55°C and a vacuum of -0.08Mpa, and concentrated to 50% of the original volume to obtain a concentrated solution. Add ethanol with a mass concentration of 96% to the concentrated solution and let it stand 20 hours of primary alcohol precipitation, the volume ratio of the concentrated solution to ethanol is 1:4, take the supernatant of the...

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Abstract

The invention belongs to the technical field of the preparation of active substances in traditional Chinese medicines, and especially relates to a preparation technology and a purpose of citrus grandis peel flavones. The preparation technology comprises steps of (1) pre-treating, wherein peels of fresh ripe fruits are cut into strips for later use; (2) extracting, wherein an ethanol solution is added to the citrus grandis peel strips, the peels are dipped, heated until boiled, and an extract is obtained; (3) condensing, wherein the extract is condensed until a total flavonoid content is higher than 38.33mg / mL, and the condensate is obtained; (4) separating and purifying; and (5) drying. The invention is advantaged in that: the preparation technology of citrus grandis peel flavones provided by the invention is stable and applicable; the flavones content of the product is higher than that obtained with prior technologies; the utilization rate of the raw materials is improved, and the extraction rate of effective components is improved; the citrus grandis peel flavones can be used for treating hyperlipidemia, reducing blood fat, treating cardiovascular diseases and enhancing cardiovascular functions.

Description

technical field [0001] The invention belongs to the technical field of preparation technology of active substances of traditional Chinese medicines, and in particular relates to a preparation technology of citrus peel flavone and its application. Background technique [0002] Changshan Huyou (Citrus changshan-huyou Y.B chang), also known as Huyou and Jinyu, is a hybrid of pomelo [C. grandis (Linn.) osbeek] and sweet orange [C. sinensis (Linn.) osbeek]. Changshan, Zhejiang is the key production area. Its skin is collected in late autumn and early winter, divided into 5-7 petals, hung up to dry in the sun or shade, and used as medicinal materials. It is warm in nature, sweet and bitter in taste, and non-toxic, and it is recorded in "Tang Materia Medica", "Materia Medica Qiuyuan", "Liezi", "Compendium" and other documents. Its functions and indications are: resolving phlegm, eliminating indigestion, lowering qi, and quick diaphragm; treating qi depression, chest tightness, co...

Claims

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Application Information

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IPC IPC(8): A61K36/752A23L1/29A61P3/06A61P9/10A61K131/00A23L33/00
Inventor 熊耀康蒋剑平张春椿徐春根
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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