A Radix Acanthopanacis Senticosi wine and its production are disclosed. The process is carried out by taking pure natural Radix Acanthopanacis Senticosi as main raw material, adding into Milkvetch Root, Barbary Wolfberry Fruit, Common Yam Rhizome, Hawthorn Fruit, Ginseng, Sea Horse and Chinese Caterpillar Fungus, extracting effective ingredients by decocting and boiling method, and blending with pure cereal spirit, honey powder, honey and royal jelly proportionally. It's simple, cheap and fast, has various raw materials and special formula, it can soften cardiovascular function, improve micro-circulation, enhance body immunity, invigorate spleen and nourish stomach, strengthen body and prevent diseases; it costs low and tastes good and can be used as medicinal diet drinking wine.