Compositions in which
aspirin is present in combination with alkaline compounds, especially those containing
water of crystallization (hydrates), deteriorate on standing. This deterioration may take several forms: It can be a physical deterioration in which such
aspirin compositions become completely unmanageable, wet, gummy, sticky masses; or
chemical decomposition in which
aspirin loses its molecular structure chiefly by losing the acetyl group. The latter is accompanied by formation of
acetic acid, the mixture developing its characteristic acetic
odor. In both cases, such compositions become entirely unsuitable for all practical commercial and medicinal purposes. Yet, when preparation of water-soluble aspirin compositions is desired, it is impossible to avoid the use of alkaline compounds. This is because the only known method of converting aspirin into soluble form is by means of reacting it with an alkaline compound to form the soluble salt of aspirin. Unexpectedly, it was discovered and is the substance of the present invention that there are two compounds both of which are alkaline and contain
water of crystallization (hydrates), and which, in combination with aspirin, give soluble compositions of outstanding stability. Unexpectedly, it was discovered and is also the substance of the present invention that there are several
sugar substitutes which have demonstrated an acceleration of absorption into the bloodstream and have demonstrated a reduction in acididity which in turn should reduce or eliminate the potential for bleeding in the
stomach. These two compounds are
sodium citrate (tri) dihydrate, and
potassium citrate (tri) monohydrate. Artificial sweeteners can also be combined in the soluble aspirin composition.