188 results about "BIO-AVAILABILITY" patented technology

Described herein is a particular type of pharmaceutical tablet, for oral use, which is formed by one or more layers, and is specifically designed for controlled release of active principles that present problems of bio-availability linked to absorption in the gastro-intestinal tract, and in particular active principles that present an erratic and unpredictable absorption linked to the presence or absence of food at the level of the stomach and / or of the first portion of the small intestine, the said pharmaceutical form being characterized in that it is completely coated with one or more films of a biocompatible and biodegradable polymeric material.

The present invention refers to new microspheres including pancreatic enzymes, pharmaceutical compositions containing them, and a process to obtain them. The process here described doesn't involve the use of solvents and proves to be remarkably shorter and efficient than the producing methods of the prior arts. The microspheres obtained, including one or more pancreatic enzymes, one or more hydrophilic low-melting polymers and eventual excipients, have an high enzymatic activity, bio-availability and stability.

Methods of enhancing the bio-availability of coenzyme Q10, and methods of supporting the cardiovascular system to accommodate the increase in cellular energy synthesis as a result of the bio-availability of coenzyme Q10 are described. Compositions which include coenzyme Q10, lactoferrin and / or angiogenin are described for use in the related methods, for multi-functional health applications.

Compositions and methods for treating osteoporosis using the compositions are disclosed where the compositions have reduced GI toxicity and improved bio-availability and include a bisphosphonate and zwitterionic phospholipid.

A free-flowing solid formulations of drugs or pharmaceutical agents which have poor aqueous solubility are obtained by admixing a liquid or gel composition that includes 1 to 30 percent by weight of the drug, 5 to 60 percent by weight of a surfactant, 10 to 40 percent by weight of water; 1 to 20 percent by weight of unsaturated fatty acid ester, 0 to 50 percent by weight water miscible pharmaceutically acceptable polyol and 1 to 10 percent by weight of phospholipid with a pharmaceutically acceptable suitable solid carrier and thereafter drying the admixture. The free-flowing powder is suitable for being formed into tablets or capsules. The drug or pharmaceutical agent is solubilized in the formulation and has significantly improved bio-availability when compared to the drug tested in its pure form.

Aqueous, anti-inflammatory steroid compositions in solution form suitable for nasal administration and having a reduced stinging sensation are provided as well as a method for treating inflammation of the nasal mucosa by intranasal administration of anti-inflammatory steroid compositions. These solution compositions may result in enhanced nasal bio-availability. The anti-inflammatory steroid composition suitable for intranasal administration includes an anti-inflammatory steroid in an amount of from about 0.0001% to about 2.0% (w / v); a cyclodextrin in an amount of from about 0.1% to about 20% (w / v); an alcohol co-solvent in an amount of from about 0.2% to about 35% (w / v); a crystallization inhibitor where required, an effective amount of an antimicrobial preservative; an effective amount of an antioxidant; an effective amount of a chelating agent; water; and a pH adjusting agent sufficient to adjust the pH of the composition to from about 4 to about 7.

Metallo-proteins including but not limited to lactoferrin (LF), transferrin (TF) and ovotransferrin (OTF) (all members of transferrin family), ceruloplasmin (CP) and metallo-thionein (MT) were found to stabilize and enhance the bio-functional activity of tocotrienol (T3), T3 mixtures or derivates. The synergism between MP and T3 also promote the intestinal transfer and the ultimate bio-availability of T3 and T3-derivatives for physiological functions. Such functional synergism includes hypocholesterolemic, anti-thrombotic, antioxidant, anti-athermogenic, anti-inflammatory and immuno-regulatory activities of T3 agents. These T3 compositions are useful as pharmaceuticals, in cosmetics, in foods and as nutritional supplements.

The invention discloses a phytoremediation method for soil with cadmium pollution. The method comprises the following steps: ryegrass is planted in soil with cadmium pollution; organic acid is added before harvest, and the organic acid is one selected from ethylene diamine tetraacetic acid, oxalic acid, glacial acetic acid, propane diacid, tartaric acid or malic acid. In the method, based on ryegrass as a biomass raw material, when the ryegrass is used to restore the soil with cadmium pollution, through activation and induction actions of the organic acid, the bio-availability of heavy metal cadmium is raised, absorption and enrichment of cadmium of plants are promoted, and therefore the phytoremediation speed of soil with heavy metal pollution is raised. In addition, the organic acid can promote increase of amount of dry matter of overground parts and root systems of ryegrass to some extent, and finally, long-term goals of harmony of soil productivity restoration and local landscapes, ecological balance and sustainable development are achieved.

The invention relates to preparation method and application of berberine fatty group organic acid salt, pertaining to pharmacy field. The chemical general formula of barberine type alkaline of the invention is shown as a formula (I), wherein, X represents organic acid group, and the berberine type alkaline is berberin, palmatine, jaterohitine or coptisine. The invention relates berberine alkaline fatty group organic acid, which is of good oral taking absorption, can be used for preparing medical components, greatly improves the bio-availability of the alkaline type, and play comparatively better effect to the therapies of such diseases as bacterial infection, heart rate abnormity, platelet aggregation, hyperlipidemia, diabetes, hypertension, cardiac failure, etc.

The invention relates to a preparing method for a complex function repairing agent for treatment of heavy metal contaminated soil. Biomass charcoal, quick lime and a siliceous material serve as raw materials, biomass charcoal based tobermorite is synthesized through a hydrothermal reaction, and a biomass charcoal based hydroxyl calcium phosphate complex agent can be generated by biomass charcoal based tobermorite in a phosphate solution. In land utilization, the complex agent has the function of enhancing soil fertility and can also effectively stabilize heavy metal ions in the soil, the mobility and the bio-availability of heavy metal are reduced to the maximum, and the purpose of in-situ repair of the heavy metal contaminated soil is achieved. The prepared complex function repairing agent has the advantages of being high in content of active ingredients, long in heavy metal stabilizing effect, wide in application range, small in using quantity, easy to prepare, low in cost and the like, and can be used for long-acting on-situ repair of farmland heavy metal contaminated soil or other industrial heavy metal contaminated soil.

A method of measuring in vivo nitric oxide and nitrite levels in individuals by providing a salivary nitrite test substrate, testing salivary nitrite levels with the test substrate, measuring nitrite levels detected in the testing; and correlating the measured nitrite levels with in vivo nitric oxide bio-availability.

The invention discloses a microbial remediation method for basic chromium pollution soil. The method comprises the following steps of: adding a bacteria solution according to mass-to-volume ratio (g:mL) of the soil to the bacteria solution of 1:3 by taking Pseudochrobactrumsaccharolyticum LY10 as a mediation strain and taking 10<7>-10<8> cellsmL<1> as the bacteria inoculation concentration, culturing at the temperature of 28 DEG C, and supplementing a culture medium for 5 days at intervals, so that the growth and metabolism activity of the bacteria is maintained. After remediation is realized within 22 days, the Cr(VI) removal rate in the soil is 95.9 percent, and the content of the exchangeable chromium can be obviously reduced; and after remediation, the occurrence form of chromium in the polluted soil is obviously changed, the bio-availability is reduced, and a good remediation effect is achieved. The method is easy to operate, economic, effective and environment-friendly and can provide a technical support for promotion of the bioremediation of the chromium pollution soil.

The invention relates to a surfactant enhanced organic polluted soil electric-biological remediation method and a surfactant enhanced organic polluted soil electric-biological remediation device, which can effectively improve the efficiency of traditional electric-biological remediation of organic pollutants. The surfactant enhanced organic polluted soil electric-biological remediation method comprises the following steps: designing a cylindrical electrode matrix configuration of an annular anode on the outer side of a central cathode; filling a soil remediation system with biochar immobilized microorganisms along the inner side of the anode to form an annular biological PRB (Permeable Reactive Barrier), and adding a surfactant into remediated soil by adopting an electric injecting mode. According to the method, the difficult problems that the organic pollutant bio-availability is low, the remediation efficiency spatial difference is large, and the overall remediation efficiency is low in the traditional soil electric-biological combined remediation are solved; the method can be used for ex-situ remediation of organic polluted soil, and can also be used for in-situ remediation.

The invention provides a novel in-situ passivation modifier for heavy metal polluted farmland soil. The in-situ passivation modifier comprises nanometer iron powder, coal ash, zeolite and a calcium magnesium phosphate fertilizer. A material obtained by mixing the nanometer iron powder, the coal ash, the zeolite and the calcium magnesium phosphate fertilizer according to a ratio which are simple in source and low in cost is adopted by the in-situ passivation modifier and is subjected to chemical reactions (precipitation, adsorption, complexing, oxidation-reduction, and the like) with heavy metals in the soil to form stable compounds so as to reduce bio-availability of the heavy metals in the soil, thus reducing absorption and accumulation of the heavy metals by plant root and achieving an objective of treating farmland soil heavy metal pollution.

The present invention is directed to a third generation form of creatine, specifically a creatine hydrochloride salt, that drives significant improvements in muscle development and recovery due to its enhanced bio-availability, while causing fewer negative side effects compared to previous forms of creatine.

The present invention relates to a primary composition comprising all essential nutrients of a fruit or a plant material, which has an increased stability, bio-availability and miscibility; and the process of forming the same. It also relates to an oral composition that contains the primary composition in a foodstuff, in a food supplement, in a cosmetic preparation or in a pharmaceutical preparation.

The invention provides a device for researching bio-availability of dissoluble organic nitrogen in water body. A main body of a filter device is a container, a hollow fiber microfiltration membrane assembly is filled inside the container, a micropore aeration disc is installed below the membrane assembly, a bottom of a reactor is conical, and a spoil disposal port is arranged at the bottom of the reactor. Another end of the hollow fiber microfiltration membrane assembly is connected with a second water collecting tank. A main body of a dissoluble organic nitrogen extraction device is a cross flow filtration device, a water inlet of the dissoluble organic nitrogen extraction device is connected with the second water collecting tank, a concentrated solution outlet of the cross flow filtration device is connected with the second water collecting tank, and a penetrating fluid outlet is connected with a third water collecting tank. A main body of an algae growth system is a reaction tank, a water inlet of the reaction tank is connected with the second water collecting tank, a temperature sensor and a heating rod are arranged in the reaction tank, and a light source capable of adjusting luminance and a light sensor are installed on the top of the reaction tank. A circulating pump is installed outside of the reaction tank to pump water at the bottom of the reaction tank to a water surface. The invention further discloses a method for researching the bio-availability of the dissoluble organic nitrogen in the water body by using the device.

The invention discloses a heavy metal passivator for reducing the bio-availability of cadmium in soil. The heavy metal passivator is prepared by mixing the following components in percentage by weight: 70 to 90 percent of biochar and 10 to 30 percent of modified sodium alginate. The heavy metal passivator disclosed by the invention not only has a function of passivating the heavy metal in the soil in situ, but also is capable of improving the soil structure and increasing the soil porosity, the pH (Potential of Hydrogen) of the soil is increased to a larger extent, and the function of repairing acidified soil is also obtained.

The invention relates to a preparation method and application of magnetically-activated hydrothermal biological carbon. The preparation method comprises the following steps: performing hydrothermal reaction on aquatic plant powder and deionized water in a reaction kettle to prepare hydrothermal biological carbon; then fully mixing the hydrothermal biological carbon, FeCl3, ZnCl2 and the deionized water and drying; putting a dried mixed sample into a box-type atmosphere furnace, performing final thermal pyrolysis at a target temperature under the condition of nitrogen protection to prepare the magnetically-activated hydrothermal biological carbon. The magnetically-activated hydrothermal biological carbon material prepared by the method can effectively absorb and remove a large amount of heavy metals like lead and copper in a water body; the composite material prepared by the method can be added into soil in which the lead and the copper exceed the standard so as to reduce the bio-availability of the lead and the copper in the soil and achieve the purposes of resisting and controlling the heavy metals.

The invention discloses an arsenic-contaminated soil repairing and retaining agent based on microbe catalytic synthesis, and a preparation and application method thereof. Currently, lots of fixing agents for repairing arsenic-contaminated soil can cause soil acidification and seriously destroy the soil property. Aiming at the problems, the fixing agent for repairing arsenic-contaminated soil is prepared from ferrous sulfate serving as raw material by steps of catalytically oxidizing thiobacillus ferrooxidans, collecting a precipitated product and performing aging modification to the precipitated product. The synthesized product is uniformly mixed with soil according to a certain proportion, the water-soluble arsenic in the contaminated soil is reduced by 99.8 percent, the effective-state arsenic is reduced by 75.4 percent, and the pH value of repaired soil is about 7. The fixing agent is simple in preparation process and low in cost, can be used for effectively reducing the mobility of arsenic and bio-availability in the soil, and hardly affects the pH value of soil. The repaired soil is good for crop growth.

The invention primarily relates to a multifunctional slow release organic fertilizer containing a heavy metal passivator and a preparation method. The fertilizer comprises the main components: thoroughly decomposed compost, a chemical nitrogen fertilizer, a biochemical inhibitor, a soil heavy metal passivating material, plant growth beneficial elements, a water retaining material and a coating liquid for coating the periphery of the organic particles. The proportion of the thoroughly decomposed compost, the chemical nitrogen fertilizer, the biochemical inhibitor, the soil heavy metal passivating material, the plant growth beneficial elements, the water retaining material and the coating liquid is 1: (0.1-0.3):(0.05-0.1):(0.01-0.2):(0.001-0.02):(0.04-0.08):(0.05-0.1). The fertilizer can reduce bio-availability of heavy metals in the heavy metal polluted soil and reduce adsorption of the heavy metals by crops and increase the content of organic matters in soil and improve the soil fertility, can promote crop growth and enhance water and fertilizer-retaining abilities of the soil, and enhance various functions of crops, for example, disease resistance, drought resistance and the like.

The invention provides a reinforced plant restoration method for lead-cadmium composite contaminated soil. The reinforced plant restoration method comprises the following steps: planting restoration plants in lead-cadmium composite contaminated soil, and injecting a DOM (dimethoxymethylamphetamine) solution into the soil within a restoration period according to soil moisture holding capacity which accounts for 60%-70% of the soil field moisture holding capacity. According to the reinforced plant restoration method disclosed by the invention, the DOM is from a mixed solution of soil leaching liquor and a straw humifying solution, and the reinforcing effect is mainly from activation effect of the DOM solution to lead / cadmium; the effect of restoring the lead / cadmium composite contaminated yellow soil is improved by changing the bio-availability of the lead / cadmium in soil through DOM.

The invention provides an efficient solidification / stabilization repair reagent for soil contaminated by heavy metals. Raw materials of the efficient solidification / stabilization repair reagent comprise gypsum, magnesium oxide and diatomite. The reagent provided by the invention is mainly for the soil co-contaminated by a plurality of heavy metals such as cadmium, zinc, copper, lead and mercury, and can effectively reduce bio-availability and mobility of the heavy metals, thereby guaranteeing safety of the soil. The selected materials are widely available; cost of the raw materials is relatively low; and the reagent has a significant effect and no secondary pollution, and is an environment-friendly heavy metal passivated repair reagent.

The invention relates to a method for repairing cadmium contaminated soil and provides a method for repairing soil cadmium contamination through titanium gypsum. The method is short in repairing period, low in cost and free of secondary pollution to the soil, and improves the use value of waste solid titanium gypsum. After the cadmium contaminated soil steeps in the field, the titanium gypsum is evenly added into the soil, and the water content of the soil keeps 30-40% of the field capacity; the raw titanium gypsum comprises CaSO4, Fe2O3, MgO, Al2O3, SiO2, P2O5 and TiO2; the Fe2O3 exists in a ferric hydroxide colloid form. The method has the beneficial effects that the titanium gypsum is added into the soil, so that the pH, CEC and Eh of the soil are effectively improved, the content of cadmium easily absorbed by plants is reduced, the bio-availability of the cadmium is decreased, and the repairing period is short; the titanium gypsum contains a large number of microelements needed by growth of plants, such as Fe, Mg, Ca and S, so that the yield of crops is improved, and no pollution is generated to the soil; efficient utilization of the titanium gypsum soil is achieved, the cost is low, and popularization is easy.

The invention provides a method for reducing cadmium pollution risk for rape. According to the method, clay mineral sepiolite or montmorillonite and organic fertilizer chicken manure are applied to middle-level and mild cadmium pollution vegetable fields and are fully evenly mixed; cadmium-rejecting rape breed Hualv Number Two is planted after stabilization for 10-30 days so as to remarkably reduce the cadmium pollution risk for the rape. According to the method, the cadmium-rejecting rape breed and a soil passivator having high passivation capability on cadmium pollution are combined, the cadmium-rejecting rape breed has the advantage of low cadmium accumulation amount; the clay mineral and the organic fertilizer can remarkably reduce content of effective state cadmium of the soil by adsorption, ion exchange and complex reaction, and soil self-cleaning capability and soil fertility conditions are improved simultaneously. By combining the cadmium-rejecting rape breed, the soil passivator, the clay mineral and the organic fertilizer, bio-availability of cadmium can be remarkably reduced, accumulation of cadmium in the rape is further reduced, and the popularization application range of the cadmium-rejecting breed is expanded. The method has the advantages of being good in effect, wide in raw sources, low in cost and wide in applied range.

The invention belongs to the technical field of heavy metal polluted soil treatment and in particular relates to a mechanochemical reduction remediation method for hexavalent chromium polluted soil. The method disclosed by the invention comprises the following steps: grinding naturally aired hexavalent chromium polluted soil in a mortar, sieving, carrying out a mechanochemical reaction on the sieved soil particles, reducing agents (such as ferrous sulfate, calcium polysulfides and the like) and zirconia in a ball mill tank according to a ratio, and transforming hexavalent chromium with high toxicity, easiness in migration and high bio-availability into trivalent chromium with low toxicity, easiness in precipitation and low bio-availability by virtue of mechanochemical reduction, thereby realizing harmless treatment of the hexavalent chromium polluted soil. The method disclosed by the invention has the characteristics of being high-efficiency, green and zero in secondary pollution and is a hexavalent chromium polluted soil remediation method with excellent application prospects.

The invention provides independently screened high-efficiency phosphate-solubilizing bacteria and a preparation method of a microbial inoculum of the phosphate-solubilizing bacteria, and belongs to the technical field of biology. The phosphate-solubilizing bacterial strain is named as Bacillus subtilis JT-1, and is identified as bacillus subtilis, which is preserved at the China Center for Type Culture Collection (CCTCC) on August 5, 2014; and the preservation number is CCTCC M 2014367. The phosphate-solubilizing bacteria can transform insoluble inorganic phosphorus into a high-quality phosphorus compound which can be directly absorbed and utilized by plants, can improve the bio-availability of the insoluble phosphorus in soil and the utilization efficiency of a phosphate fertilizer, can save a fertilizer and increase production, and have important meaning and application value in the aspects of cultivating and developing the soil ecological fertility, and keeping agricultural ecological balance.

Methods of enhancing the bio-availability of coenzyme Q10, and methods of supporting the cardiovascular system to accommodate the increase in cellular energy synthesis as a result of the bio-availability of coenzyme Q10 are described. Compositions which include coenzyme Q10, lactoferrin and / or angiogenin are described for use in the related methods, for multi-functional health applications.