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Sudden death and hypertension resistant metoprolol intelligent medicine release system and its preparation method

An intelligent, high blood pressure technology, applied in the field of biomedicine, can solve the problems of not being able to achieve the effect, not having the characteristics of slow and controlled release, and achieve the effect of avoiding blood pressure fluctuations and preventing sudden death

Inactive Publication Date: 2013-01-30
王登之
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent takes into account the chronological rhythm of the onset of hypertensive angina pectoris, it does not have the characteristics of slow and controlled release, and cannot achieve a better effect in the body

Method used

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  • Sudden death and hypertension resistant metoprolol intelligent medicine release system and its preparation method
  • Sudden death and hypertension resistant metoprolol intelligent medicine release system and its preparation method
  • Sudden death and hypertension resistant metoprolol intelligent medicine release system and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027]

[0028] Preparation method: take part of the main drug and auxiliary materials of the main controlled release layer according to the prescription amount, pass through an 80-mesh sieve and mix evenly, use an adhesive to make a soft material, pass through an 18-mesh sieve to make wet granules and dry, add an appropriate amount of magnesium stearate, Sieve through a 16-mesh sieve, mix well and set aside; press the well-mixed main release layer granules into tablets; mix the film coating material according to the prescription, spray coat the surface of the tablet until the weight gain of the tablet reaches the expected requirement, and the product is ready.

Embodiment 2

[0030]

[0031] Preparation method: take part of the main drug and auxiliary materials of the main controlled release layer according to the prescription amount, pass through an 80-mesh sieve and mix evenly, use an adhesive to make a soft material, pass through an 18-mesh sieve to make wet granules and dry, add an appropriate amount of magnesium stearate, Sieve through a 16-mesh sieve, mix well and set aside; press the well-mixed main release layer granules into tablets; mix the film coating material according to the prescription, spray coat the surface of the tablet until the weight gain of the tablet reaches the expected requirement, and the product is ready.

Embodiment 3

[0033]

[0034] Preparation method: take part of the main drug and auxiliary materials of the main controlled release layer according to the prescription amount, pass through an 80-mesh sieve and mix evenly, use an adhesive to make a soft material, pass through an 18-mesh sieve to make wet granules and dry, add an appropriate amount of magnesium stearate, Sieve through a 16-mesh sieve, mix evenly, and use a pelletizing machine to make pellets; mix the film coating material according to the prescription, spray coat the surface of the pellets until the weight gain of the pellets reaches the expected requirement, and the product is ready.

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Abstract

The invention relates to a new medicinal preparation of a medicinal intelligent medicine release system, belongs to the biological medicine field, and concretely relates to a sudden death and hypertension resistant metoprolol intelligent medicine release system and its preparation method. The metoprolol intelligent medicine delivery system is characterized in that the metoprolol intelligent medicine release system is formed by a main controlled release layer (a tablet core, a pill core or a pellet), and the external of the main controlled release layer is coated with an intelligent film coat. Medicine release is carried out according to the human blood pressure rhythm 3-6h after the preparation is orally taken, simultaneously the main controlled release layer slowly releases medicines according to a preset medicine release speed, the highest plasma medicine concentration lasts for 10-16h, and the medicine performs the curative effect within 24h. The preparation can control the cardiogenic sudden death, the cerebral hemorrhage, the cerebral infarction and the like caused by the physiological change of the human blood pressure and the heart rate after midnight, and has very good clinical application prospects.

Description

technical field [0001] The invention relates to a novel pharmaceutical preparation of an intelligent drug delivery system, belonging to the field of biomedicine. Background technique [0002] Metoprolol, whose chemical name is 1-isopropylamino-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L(+)-tartrate, is a white crystalline powder, Odorless, bitter taste. Soluble in water, soluble in ethanol or chloroform, almost insoluble in ether or acetone. Metoprolol belongs to class 2A, β1-blockers without partial agonistic activity (cardioselective β-blockers). It has selective blocking effect on β1-receptor, no PAA (partial agonistic activity), no membrane stabilizing effect. Its blocking effect on β-receptor is about equal to that of propranolol (PP), and its selectivity to β1-receptor is slightly inferior to that of atenolol. The effects of metoprolol on the heart, such as slowing heart rate, inhibiting contractility, reducing self-discipline and delaying atrioventricular conductio...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/30A61K9/00A61K31/138A61K47/38A61K47/44A61P9/12A61P9/10A61P9/06A61P9/04A61P5/16
Inventor 王登之周艳侯鹏刘娟娟
Owner 王登之
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