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Traditional Chinese medicine active part compound preparation for curing cardiac and cerebral vascular diseases and its preparing method

A technology for cardiovascular and cerebrovascular diseases and effective parts, applied in the field of medicine, can solve problems such as unclear mechanism, difficult quality control, and unclear ingredients

Inactive Publication Date: 2003-06-25
山东希尔康泰药业有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine compound has the disadvantages of unclear ingredients, unknown mechanism, difficult quality control, and unstable curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Get 10kg of Salvia miltiorrhiza, soak 30min with 70% acetone of 10 times the amount and start percolation, the percolation solution is concentrated under reduced pressure to no acetone smell, dilute the concentrated solution with an appropriate volume of water, according to the ratio of adsorption capacity 1: 1 (resin content and the amount of medicinal material) through the AB-8 macroporous resin column, that is, the column is filled with 10kg macroporous resin. First eluted with 4 times the volume of deionized distilled water, then eluted with 10 times the column volume of 20% ethanol solution, and collected the eluate to obtain the salvianolic acid component. Concentrate under reduced pressure at 40°C to remove ethanol, continue to concentrate to 1 / 10 of the original volume, filter through a 0.45 microporous membrane, and freeze-dry the concentrated solution according to the following process: -50°C for 4 hours, -10°C for lyophilization, and warm to 20 ° C for 3 hours...

Embodiment 2

[0043] Get 10kg of Salvia miltiorrhiza, soak with 10 times the amount of 50% acetone for 30min and then start percolating. The percolating liquid is concentrated under reduced pressure until there is no acetone smell, dilute the concentrated solution with an appropriate volume of water, and use a ratio of 1:1 (resin content) and the amount of medicinal material) through the AB-8 macroporous resin column, that is, the column is filled with 10kg macroporous resin. First eluted with 4 times the volume of deionized distilled water, then eluted with 12 times the column volume of 30% ethanol solution, and collected the eluate to obtain the salvianolic acid component. Concentrate under reduced pressure at 45°C to remove ethanol, continue to concentrate to 1 / 10 of the original volume, filter through a 0.45 microporous membrane, and freeze-dry the concentrate according to the following process: -50°C for 3 hours, -10°C for 3 hours, and heat up to Keep warm at 20°C for 2 hours, and then...

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Abstract

The compound Chinese medicine preparation consists of general salviandic acid extracted from danshen and general arasaponin extracted from notoginseng in certain proportion. In has the same pharmaceutical function and clinical effect as traditional Chinese medicine and less impurity content. It may be prepared into various preparation forms for treating cerebral infarction, cerebral ischemia, coronary heart disease, angina pectoris, myocardial infarction, etc. The present invention is one safety, effective, stable, controllable and convenient compound Chinese medicine preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a composition of effective parts of traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Specifically, it is composed of total salvianolic acid in the traditional Chinese medicine Salvia miltiorrhiza and total glycosides in Panax notoginseng Pharmaceutical composition and preparation method thereof. Background technique [0002] Danshen is a traditional traditional Chinese medicine for promoting blood circulation and removing blood stasis. A large number of studies have shown that the active ingredient of Danshen is total salvianolic acid, among which salvianolic acid B magnesium salt has the strongest effect, and the traditional water extraction method cannot obtain salvianol-containing Acid B more total salvianolic acid. [0003] Panax notoginseng is a traditional traditional Chinese medicine for di...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/10
Inventor 张卫东苏娟张川
Owner 山东希尔康泰药业有限公司
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