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Traditional Chinese medicine active part composition for curing cardio and cerebral vascular disease and its preparing method

A technology for cardiovascular and cerebrovascular diseases and effective parts, applied in the field of medicine, can solve problems such as unclear mechanism, difficult quality control, and unclear ingredients

Inactive Publication Date: 2007-11-07
山东希尔康泰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine compound has the shortcomings of unclear ingredients, unknown mechanism, difficult quality control, and unstable curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Get 10kg of Salvia miltiorrhiza, soak 30min with 70% acetone of 10 times the amount and start percolation, the percolation solution is concentrated under reduced pressure to no acetone smell, dilute the concentrated solution with an appropriate volume of water, according to the ratio of adsorption capacity 1: 1 (resin content and the amount of medicinal material) through the AB-8 macroporous resin column, that is, the column is filled with 10kg macroporous resin. First eluted with 4 times the volume of deionized distilled water, then eluted with 10 times the column volume of 20% ethanol solution, and collected the eluate to obtain the salvianolic acid component. Concentrate under reduced pressure at 40°C to remove ethanol, continue to concentrate to 1 / 10 of the original volume, filter through a 0.45 microporous membrane, and freeze-dry the concentrated solution according to the following process: -50°C for 4 hours, -10°C for lyophilization, and warm to 20 ° C for 3 hours...

Embodiment 2

[0040] Get 10kg of Salvia miltiorrhiza, soak with 10 times the amount of 50% acetone for 30min and then start percolating. The percolating liquid is concentrated under reduced pressure until there is no acetone smell, dilute the concentrated solution with an appropriate volume of water, and use a ratio of 1:1 (resin content) and the amount of medicinal material) through the AB-8 macroporous resin column, that is, the column is filled with 10kg macroporous resin. First eluted with 4 times the volume of deionized distilled water, then eluted with 12 times the column volume of 30% ethanol solution, and collected the eluate to obtain the salvianolic acid component. Concentrate under reduced pressure at 45°C to remove ethanol, continue to concentrate to 1 / 10 of the original volume, filter through a 0.45 microporous membrane, and freeze-dry the concentrate according to the following process: -50°C for 3 hours, -10°C for 3 hours, and heat up to Keep warm at 20°C for 2 hours, and then...

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Abstract

The composition of Chinese medicine effective parts for treating cardiac and cerebral vascular diseases consists of general salvianolic acid and general astragalus saponin in certain ratio. The compound medicine has raised pharmacological effect and clinical curative effect and reduced impurity content. It may be prepared into various preparation forms. It is used in treating coronary heart disease, angina pectoris, myocardial ischemia, heart failure, arrhythmia, cerebral infarction and cerebral ischemia; and is safe, effective stable, controllable and convenient.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a composition of effective parts of traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, in particular to a composition composed of total salvianolic acid in salvia miltiorrhiza and total glucosides in astragalus Pharmaceutical compositions and methods for their preparation. Background technique [0002] Salvia miltiorrhiza is a traditional traditional Chinese medicine for promoting blood circulation and removing blood stasis. A large number of studies have shown that the active ingredients of salvia miltiorrhiza are total salvianolic acid, among which the magnesium salt of salvianolic acid B has the strongest effect, and the traditional water extraction method cannot obtain salvianolic acid B The higher total salvianolic acid can only be its decomposition product danshensu and the toxic component prot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/481A61K9/00A61P9/10
Inventor 张卫东苏娟张川
Owner 山东希尔康泰药业有限公司
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