256 results about "Cerebral vascular disorders" patented technology

The composition of Chinese patent medicine for curing cardio-cerebral vascular diseases comprises (wt%) 82-87% of bran and coarse grain, 13-18% of plant medicinal material for curing cerebrovascular disease and microscale of saccharifying enzyme and lactobacillin, which is characterized by that the composition of said plant medicinal material comprises (wt%) 28-37% of main medicinal material, 23-30% of secondary medicinal materials, 27-41% of auxiliary medicinal material and 5-7% of flavouring material, and its preparation method includes the following steps: selecting materials, pulverizing,mixing, steaming, cooling, inoculating, showering, sterilizing, filtering, inspection, packaging and putting in storage.

The present invention discloses thiopheno pyridine substituted acetyl hyarazine derivative compound as shown in expression I and its pharmaceutically acceptable salt, medicine composition with the compound as effective component, and their application as platelet aggregation resisting medicine, especially as medicine for preventing and treating platelet aggregation caused coronary artery syndromes, myocardial infarction, myocardial ischemia and other cardiac and cerebral vascular diseases.

Solid, pharmaceutical dosage forms of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof are disclosed. In addition, methods of use are disclosed for the treatment, inter alia, of cerebral vascular disorders, anxiety disorders; mood disorders; schizophrenia; schizophreniform disorder; schizoaffective disorder; cognitive impairment; chronic neurodegenerative disorders; inflammatory diseases; fibromyalgia; complications from herpes zoster; prevention of tolerance to opiate analgesia; withdrawal symptoms from addictive drugs; and pain.

A liposome of breviscapine for preparing the medicines to cure cerebral thrombus and coronary heart disease is prepared from breviscapine, phosphatide, cholesterol, and supporting agent chosen from sorbitol, mannitol, cane sugar, sodium chloride, water-soluble starch, etc by different methods. Its advantages are high absorption rate, high biologic utilization rate, and high stability.

This invention is directed to methods and compositions which impede the development and progression of diseases associated with subclinical inflammation. Subclinical inflammation is commonly associated with atherosclerotic cardiovascular disease, coronary disease or cerebrovascular disease. The methods and compositions of the invention are also particularly suited to providing therapy for subclinical inflammation in diabetic and prediabetic patients. Methods of the invention comprise administration of DHA alone and in combination with antiplatelet drugs.

The present invention relates to a compound medicine for preventing and curing angiocardiopathy and cerebrovascular disease, belonging to the field of chemical medicine. It is characterized by that said compound medicine includes sexual hormones medicine, lipid-reducing medicine, hypotenser, hypoglycemic medicine and anticoagulant medicine. Said compound medicine can be made into various dosage forms. Besides, said compound medicine also can be used for curing the diseases of climacteric syndrome, osteoporosis, endometrial carcinoma, diabetes and metabolic syndrome, etc.

The present invention relates to, among other things, methods for treating trigeminal cephalgias such as migraine and migraine like headaches and other cerebrovascular conditions associated with pain and or inflammation. When non-steroidal anti inflammatory drugs (NSAIDs), such as ketoprofen, are applied locally using specific topical formulations immediate relief of pain is obtained. Intense pain is typically reduced to mild pain or no pain within 30 minutes of application of the topical formulation. The NSAID may be given in combination with other pharmacological agents, such as vasoconstrictors, opioids, decongestants and / or non-opioid migraine drugs, such as triptans and ergots and agents that affect serotonin receptors as agonists, antagonists or partial agonists.

The invention relates to a curcumin injection comprises the complex of curcumin and macromolecular complexing agent of hydroxyl propyl beta-cyclodextrin having polyhydroxy, water-soluble medicinal findings for injection and / or freeze-drying excipient, the dosage form includes transfusion and freeze dried. The invention also provides the process for preparing the curcumin injection, which can be used in the treatment for cancer, leukemia, hepatic diseases and cranial vascular diseases.

The present invention provides one kind of total paeonoside extract and its preparation process as well as the application of the total paeonoside extract in preparing medicine for preventing and treating cardiac and cerebral vascular diseases. Specifically, the total paeonoside extract is used in preparing medicine for preventing and treating cerebral apoplexy, cerebral ischemia / re-perfusion damabe, brain trauma, senile dementia, etc.

The present invention is one kind of glycoside preparation and its preparation process. The glycoside preparation is prepared with American ginseng and / or ginseng, astragalus root and notoginseng as material and through extraction with ethanol solution in certain concentration and other steps. The glycoside preparation has the functions of refreshing, improving memory, promoting blood circulation to disperse blood clots, lowering blood sugar and pressure, preventing cardiac and cerebral vascular diseases, etc.

The invention discloses a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, which comprises 5.0-80.0% of danshensu extract containing danshensu 50-98%, 15.0-93.0% of pseudo-ginseng extract containing total notoginsen triterpenes 70-98%, and natural borneol or rosewood oil 2.0-15.0%. The composition has evident functions in resisting cerebral ischemia and myocardial ischemia, the curative effect is better than the application of single extract of red sage root or notoginseng, thus providing a more effective and more convenient Chinese medicinal composition and preparation clinically.

The invention discloses a pig blood protein-free extract preparation, pertaining to the technical field of biochemical drugs. The pig blood protein-free extract freeze-dried powder injection preparation is prepared by pig blood protein-free extract and an excipient, and the weight ratio of the pig blood extract and the excipient is 200: 30 to 500. The pig blood protein-free extract of the invention applies pig blood as a raw material source to replace calf blood in the preparation of drugs for the treatment of cerebral vascular diseases, the improvement of nervous function defects caused by cerebral ischemia and craniocerebral trauma and the treatment of peripheral blood disorder symptoms, thus producing the biochemical drugs with the same function, replacing the similar products with the calf blood source, becoming the best choice of drug for the treatment and the auxiliary treatment of cardiovascular and cerebrovascular diseases and having very wide range of clinical application prospect. The product of the invention adopts the pig blood as the raw material, compared with the similar calf blood products, the product has the product advantages of high safety and high biological activity; furthermore, as the raw material is easy to obtain, the cost is low, the production process is advanced, the period is short and the yield is high, the product of the invention has the price advantage compared with the similar calf blood products.

The invention discloses a medicinal composition for preventing and treating cardiac and cerebral vascular diseases, consisting of antler blood, ginseng, milkvetch root, Chinese angelica, Chinese caterpillar fungus, medlar, fleeceflower root, manyprickle acathopanax root, fiveleaf gynostemma herb, red sage root, safflower, lucid ganoderma, red paeony root, Szechuan lovage rhizome, earthworm, pueraria root, amber, hawthorn, algae, rose flower, tall gastrodia tuber and bear gall. The medicinal composition has the functions of adjusting the immunity of the organism and the functions of a neuroendocrine system, improving the circulation of cerebral blood substances, reducing the blood fat and blood viscosity, improving the brain function, preventing and treating the cardiac and cerebral vascular diseases, delaying the ageing and the like. The medicinal composition can prepared into capsules, tablets, granules, pills, soft capsules and other dosage forms.

The invention discloses a series health-care food containing pearl and kudzu root and a preparation method thereof. The food is prepared by matching natural pearl and kudzu root which can be taken both as food and medicine with vitamin, medlar, a sweetening agent and appropriate accessories according to a certain proportion. The health-care food contains organic calcium, inorganic calcium, vitamin and a plurality of trace elements which are needed by human body, and the food further contains components such as flavonoid daidzin, daidzein, xylopuerarin, kudzu powder flavin, and great amount of starch, therefore, the food has the functions of beautifying the face and enlarging the breast, nourishing the tendons and channels and preventing cerebral-cardiovascular diseases, and is taken as health products which are fit for women, the middle aged people and the old, thus delaying senility, strengthening the body and maintaining the beauty and youth of skin.

The invention belongs to the technical field of medicines and relates to the use of the chitosan oligosaccharide in the preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases. Pharmacodynamic experiments prove that chitosan has remarkable effect of resisting cerebral ischemia, cerebral anoxia and the like, is widely available, can be absorbed easily by bodies, has small toxic and side effects and has a bright application prospect.

The compound for treating cardiac and cerebral vascular diseases is triethoxyl quercetin. The preparation process includes the following steps: A. hydrolyzing Troxerutin as material with beteroside hydrolase through stirring at 30-70 deg c for 3-5 days; and B. filtering, water washing the precipitate and drying. Triethoxyl quercetin has pharmacological activity obviously superior to Troxerutin. Different forms of medicine may be prepared with the compound as active component for preventing and treating cardiac and cerebral vascular diseases and cerebral apoplexy.

The composition of Chinese medicine effective parts for treating cardiac and cerebral vascular diseases consists of general salvianolic acid and general astragalus saponin in certain ratio. The compound medicine has raised pharmacological effect and clinical curative effect and reduced impurity content. It may be prepared into various preparation forms. It is used in treating coronary heart disease, angina pectoris, myocardial ischemia, heart failure, arrhythmia, cerebral infarction and cerebral ischemia; and is safe, effective stable, controllable and convenient.

The invention relates to the field of medical technology, which discloses a new usage of a petasites tricholobus franch extract and the contained bakkenolide compound in the preparation of drugs for prevention and treatment for cardiovascular and cerebrovascular diseases. The biological activity tests show that, the petasites tricholobus franch extract and the contained bakkenolide compound can significantly reduce the encephalic necrosis percentage of the rats with local cerebral ischemia, improve the behavior score of the ischemic rats and alleviate volume of brain edema and cerebral infarction of the rats with ischemia reperfusion injury, thus prompting that the petasites tricholobus franch extract and the contained bakkenolide compound have significant protective effect on the cerebral ischemia injury. The petasites tricholobus franch extract and the contained bakkenolide compound can further significantly reduce the J-point displacement caused by ISO and the LDH level in plasma, significantly reduce the scope of myocardial ischemic myocardial infarction of the rats caused by coronary artery ligation and lower the LDH level in the plasma of the rats with the myocardial ischemia. As the petasites tricholobus franch extract and the contained bakkenolide compound have good effects on the prevention and the treatment for heart and brain ischemic diseases aspects, the petasitestricholobus franch extract and the contained bakkenolide compound can be used in the preparation of drugs for prevention and treatment for cardiovascular and cerebrovascular diseases, including coronary heart disease, cerebral ischemia, cerebral infarction (stroke), myocardial infarction and so on.

The present invention is dispersive red yeast tablet prepared via advanced preparation process and has high bioavailability. Compared with available red yeast preparations, the dispersive red yeast tablet has the features of fast disintegration, fast effective component effusion, high bioavailability, high clinical effect, etc. The dispersive red yeast tablet of the present invention is suitable for cardiac and cerebral vascular diseases patients, especially the patients with acute attack of cardiac and cerebral vascular diseases and difficulty in swallowing solid medicine preparation, and may be used as substitute of the available red yeast preparation.

The invention discloses a medicinal composition containing weinaolutong (7, 3', 4'-troxerutin) obtained by hydroxyethylating eldrin and brain extract which is extracted form brain tissue of mammalian except human. The medicinal composition contains 1 to 1000 parts of weinaolutong, by weight, and the weight of the weinaolutong in the medicinal composition is 0.1 to 200 times bigger than total nitrogen content in the brain extract. The invention also discloses preparation method and use of the medicinal composition. The medicinal composition can restrain platelet agglutination thereby preventing thrombosis, and can regulate and improve brain supersession, and is used for treating acute and chronic cerebrovascular disease and sequela such as brain dysfunctional caused by craniocerebral trauma and cerebrovascular disease; and can also be used for treating occlusive syndrome, arteriosclerosis, thrombosis phlebitis, capillary bleeding and dropsy caused by elevation of vascular permeability.

The invention belongs to the field of research and development of traditional Chinese medicines and particularly relates to a Chinese medicinal formulation containing effective fractions for treating cerebrovascular diseases. The Chinese medicinal formulation is developed based on the compatibility theory of traditional Chinese medicine in combination with the modern pharmacodynamic screening and implemented by composition-effectiveness relationship, component compatibility, optimum design and modern pharmaceutical techniques. The Chinese medicinal formulation contains Radix Paeoniae Rubra effective fraction (total glycosides of Radix Paeoniae Rubra) and Herba Erigerontis effective fraction (total flavonoids and total caffeates of Herba Erigerontis) and is characterized and advantageous in synergistic effect. The pharmacodynamic experimental result shows that the Chinese medicinal formulation can improve cerebral ischemia, increase the brain blood flow, and inhibit platelet aggregation, and is superior in protection against cerebral ischemia to the similar products available in the market.

The medicine for treating cardiac and cerebral vascular diseases is prepared with astragalus root and notoginseng as material, and is Chinese medicine injection, including injection liquid, transfusion liquid and freeze dried powder for injection, prepared through extraction, purification and addition of proper amount of medicinal supplementary material. The medicine has high stability and long effective period, and may be used in intramuscular injection, intravenous injection and intravenous instillation. Pharmacodynamic test shows that the medicine can protect brain against oxygen lack and cardiac muscle damage, raise anaerobic resistance, lower serum LDH and CK activity and reduce myocardial infarction range. The medicine is used in treating cardiac and cerebral vascular diseases and has fast acting, determined curative effect and no toxic side effect.

The gingko medicine composition consists of gingko leaf extract and ligustrazine phosphate in the amount of 1-100 times of gingko leaf extract. The preparation process of the medicine composition is also disclosed. As the compound preparation, the medicine composition of the present invention has the complementary and synergistic effects of gingko leaf extract and ligustrazine phosphate, including promoting blood circulation to disperse blood clots, resisting platelet aggregation, dilating blood vessel and improving microcirculation, and may be used in preparing medicine for ischemic cardiac and cerebral vascular diseases.

The invention relates to a collateral-dredging and blood sugar reducing producut and preparation method based on inner steady reconstruction theory, comprising a compatibility of at least three, or six to ten, and at most 22 pieces of herbs of radix rehmanniae, radix asparagus, ginseng and other herbs; also comprising processed dark green tea and active ingredients; which is characterized in that the product is a new Chinese medicine or functional food for diabetes treatment or blood sugar reducing assistant remedy, and is made according to latest technique. The product has the advantages of obvious blood sugar reducing therapeutic effect as well as blood-fat reducing, blood pressure reducing, cardiovascular and cerebral diseases controlling function.

The present invention provides a method for treating or ameliorating cerebrovascular diseases in a subject by using peptides isolated from extracts from rabbit skin inflamed by vaccinia virus. The present invention also provides a peptide comprising an amino acid sequence having at least 70% identity to SEQ ID NO:1, or variants, mutants, derivatives, or fragments thereof.

The invention discloses a processing method of dendrobe health care black tea. A processing technique comprises sorting, cleaning, withering, rolling, incipient drying and re-firing drying. In the technical scheme, room temperature heavy-withering, medium-temperature incipient drying and high temperature re-firing technologies are adopted, overmuch organic acid forming ways caused by fermentation and a high temperature incipient drying process in the traditional technique are avoided, the high temperature re-firing technique is adopted to basically remove herbal flavour of dendrobe leaves and achieve representative high-fired fragrance and sweetness, and thus the dendrobe tea processed in this way is tight in twig, reddish brown and glossy in color, mellow in taste, and good, fragrant and sweet in aftertaste, has effects of nourishing yin and boosting essence, beautifying and detoxifying, nourishing the stomach and intestine, and improving eyesight, and has perfect improvement effects in improving immunity, and relieving insomnia, cardiovascular disease and diabetes.

The present invention relates to a kind of medicine composition, and its preparation process and application. The said medicine composition contains mainly bilobalide and paeoniflorin. The medicine composition of the present invention may be used in treating and preventing diabetes, senile dementia and cardiac and cerebral vascular diseases and in preventing recurrence of cardiac and cerebral vascular diseases.

The present invention discloses a medicine composition. Said medicine composition contains troxerutin obtained by making rutin undergo the process of hydroxyethylation, brain extract extracted from brain tissue of mammal except for human being and ganglioside extracted from brain tissue of mammal except for human being. Said invention also provides the concrete mixing ratio of the above-mentioned three components, and provides its preparation process and application.

The present invention relates to a kind of medicine prepared with effective components extracted from natural plant medicine materials and for treating cardiac and cerebral vascular diseases and its preparation process. The medicine consists of gensenoside Rb3 in 1-90 wt% and medicinal supplementary material the rest. The medicine is prepared into tablet, coated tablet, oral controlled release preparation, capsule, etc. and is used in treating hyperlipemia, atherosclerosis, coronary heart disease and other cardiac and cerebral vascular diseases.

The present invention belong to the field of Chinese medicine technology, in the concrete, it discloses a Chinese medicine for effectively curing cardio-cerebral vascular diseases, its preparation method and application. Said Chinese medicine is made up by using 9 Chinese medicinal materials of rhodiola root, schisandra berry, Chinese angelica root, biota seed, spiny jujube kernel and others through a certain preparation process. Said Chinese medicine can be used for mainly curing the diseases of angina pectoris, hypertension, hyperlipemia and arteriosclerosis, etc. Besides, said invention also provides the concrete steps of its preparation process.