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Preparation and application of red rice dispersible tablet

A technology of dispersible tablets and red yeast rice, which is applied in the field of medicine, can solve the problems of smaller particles of the main drug, poor dissolution, and increased surface area.

Inactive Publication Date: 2005-04-13
张帆 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0031] 3. Before the preparation process of Hongqu Dispersible Tablets, the main drug is micronized. After the drug is micronized, it will be transformed into the original drug powder in the body after the second disintegration. Due to the micronized treatment, the main drug particles are significantly The surface becomes smaller, the surface area increases greatly, and the dissolution is significantly improved; ordinary tablets lack the micronization process, and the active substances of red yeast rice are mainly hydrophobic components, so the dissolution is poor

Method used

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  • Preparation and application of red rice dispersible tablet
  • Preparation and application of red rice dispersible tablet
  • Preparation and application of red rice dispersible tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Prescription of Red Yeast Dispersible Tablets:

[0074] Red yeast rice 300g

[0075] CMS-Na 25g

[0076] Microcrystalline Cellulose 100g

[0077] L-HPC 25g

[0078] Crosslinked CMC-Na 25g

[0079] Micronized silica gel 6g

[0080] Magnesium Stearate 4.5g

[0081] 80% ethanol appropriate amount

[0082] Made into 1000 pieces

[0083] Preparation method: Weigh red yeast rice according to the above prescription, put it in a particle ball mill and grind it for 2 hours, take it out and pass it through a 120-mesh sieve, and weigh microcrystalline cellulose, L-HPC, cross-linked CMC-Na according to the prescription amount, 2 / 3 Prescribed amount of CMS-Na, mixed evenly; soft material made of 95% ethanol, granulated with 24 mesh, dried at 60°C, granulated, added the remaining amount of CMS-Na, micron...

Embodiment 2

[0086] Prescription of Red Yeast Dispersible Tablets:

[0087] Red Yeast Extract 50g

[0088] Low Substitution-Hydroxypropyl Cellulose 20g

[0089] Microcrystalline Cellulose 100g

[0090] Lactose 100g

[0091] 5% PVP K30 Solution 100g

[0092] Talc powder 6g

[0093] Made into 1000 pieces

[0094] Preparation method: Take red yeast rice and add 5 times the volume of ethanol, ultrasonically extract, 30min each time, extract twice, combine the extracts, recover under reduced pressure, and obtain red yeast rice extract; weigh the red yeast rice extract and lactose according to the above preparation prescription , placed in an airflow mill and crushed, passed through a 200-mesh sieve, added microcrystalline cellulose and low-substituted-hydroxypropyl cellulose, mixed evenly, and mixed with 5% PVP K30 Soft material made from ethano...

Embodiment 3

[0097] Prescription of Red Yeast Dispersible Tablets:

[0098] Red Yeast Extract 200g

[0099] Low Substitution-Hydroxypropyl Cellulose 20g

[0100] Microcrystalline Cellulose 50g

[0101] Sodium Lauryl Sulfate 4g

[0102] Lactose 50g

[0103] 5% PVP K30 Solution 100g

[0104] Talc powder 6g

[0105] Made into 1000 pieces

[0106] Preparation method: take red yeast rice and add 5 times the volume of 70% acetone solution, heat reflux extraction, 60 minutes each time, extract twice, combine the extracts, recover under reduced pressure, and obtain red yeast rice extract; weigh red yeast rice according to the above prescription The extract, lactose and sodium lauryl sulfate were pulverized in a jet mill, passed through a 200-mesh sieve, added microcrystalline cellulose and 1 / 2 prescription amount of low-substituted-hydroxy...

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Abstract

The present invention is dispersive red yeast tablet prepared via advanced preparation process and has high bioavailability. Compared with available red yeast preparations, the dispersive red yeast tablet has the features of fast disintegration, fast effective component effusion, high bioavailability, high clinical effect, etc. The dispersive red yeast tablet of the present invention is suitable for cardiac and cerebral vascular diseases patients, especially the patients with acute attack of cardiac and cerebral vascular diseases and difficulty in swallowing solid medicine preparation, and may be used as substitute of the available red yeast preparation.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the invention of a highly bioavailable red yeast rice preparation, that is, the red yeast rice dispersible tablet. Background technique [0002] Cardiovascular and cerebrovascular diseases have always been the enemy that threatens human health. In my country, with the gradual improvement of living standards, changes in lifestyles, and my country's gradual entry into an aging society, the threat of cardiovascular and cerebrovascular diseases is becoming increasingly serious. Statistics from epidemiology show that the prevalence, morbidity, and mortality of cardiovascular and cerebrovascular diseases in my country have continued to rise for 30 years; there are 5 to 6 million stroke patients in the country; the number of new cases is about 180,000 to 200,000 per year ; In recent years, the statistics of cardiovascular and cerebrovascular disease deaths accounted for 60% of the total death toll; ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P3/06A61P9/10
Inventor 张帆
Owner 张帆
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