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Chinese medicinal formulation containing effective fractions for treating cerebrovascular diseases and preparation method thereof

A technology for cerebrovascular diseases and effective components, applied in the field of research and development of traditional Chinese medicine, can solve the problems of unclear material basis of traditional Chinese medicine and difficult control of quality standards

Inactive Publication Date: 2013-01-02
GUIYANG MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine preparation with effective components for the prevention and treatment of cerebrovascular diseases. Compatible with total caffeic acid esters, it has a synergistic effect. It not only retains the multi-level and multi-target synergistic characteristics of traditional Chinese medicine, but also overcomes the shortcomings of unclear material basis and difficult control of quality standards in traditional Chinese medicine. It can better play the role of traditional Chinese medicine. The characteristics and advantages of medicine have improved the scientific and technological content of traditional Chinese medicine

Method used

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  • Chinese medicinal formulation containing effective fractions for treating cerebrovascular diseases and preparation method thereof
  • Chinese medicinal formulation containing effective fractions for treating cerebrovascular diseases and preparation method thereof
  • Chinese medicinal formulation containing effective fractions for treating cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental example 1: Screening research on effective components of Erigeron breviscapine and Radix Paeoniae Rubra

[0030] According to the properties and pharmacological activities of the chemical components contained in the prescription medicinal materials, using modern extraction and separation technology, the total flavonoids and total caffeic acid esters were separated from Erigeron breviscapine, and the total glucosides and total phenolic acids of paeony were separated from Radix Paeoniae Rubra, and were extracted with Acute cerebral ischemia and anti-platelet aggregation were used as evaluation indicators, and the experimental design was carried out by using the component elimination method to study the combination effect and compatibility relationship of the four types of components in Erigeron breviscapus and Radix Paeoniae Rubra.

[0031] (1) Protective effect on acute cerebral ischemia in mice:

[0032] Take Kunming mice, weighing 18-22 g, of both sexes, a...

experiment example 2

[0043] Experimental Example 2: Optimizing the compatibility of effective components of Erigeron breviscapus and Radix Paeoniae Rubra

[0044] In order to find the best compatibility of the effective components of Erigeron breviscapus and Radix Paeoniae Rubra, the orthogonal t-value method was used to further design the experimental design, taking acute cerebral ischemia and ADP-induced platelet aggregation as the evaluation index, and the effects of the above-mentioned Erigeron breviscapus and Radix Paeoniae Rubra on the Compatibility study of the four types of components.

[0045] (1) Protective effect on acute cerebral ischemia in mice: see Table 3 for the results.

[0046] Table 3 L 8 (2 7 ) Orthogonal t-value method experiment table and results (n=10)

[0047]

[0048] Note: Levels 1 and 2 represent no medication and medication, respectively. m 1 , M 2 , is the sum of the medicinal effects of levels 1 and 2 in the column, D is the extreme difference, Se is the act...

experiment example 3

[0065] Experimental Example 3: Effects of Erigeron breviscapus and Radix Paeoniae Rubra effective components in combination with traditional Chinese medicine on ischemia-reperfusion injury of middle artery in rats

[0066]Based on the fact that the combination of total flavonoids and total caffeic acid esters in Erigeron breviscapine and total glucosides of paeony in Radix Paeoniae Rubra has better pharmacological activities in cerebrovascular and promoting blood circulation and removing blood stasis, the best drug selected from the test The curative effect of the compatible components was compared with that of similar drug preparations already on the market (Breviscapita Dripping Pills, Huatuo Zaizao Pills). Use SPSS13.0 software to carry out analysis of variance (One-way ANOVA) and multiple comparison (LSD method) to compare the differences between the groups under drug intervention, and evaluate the effect of the combination preparation of Erigeron breviscapus and Radix Paeo...

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Abstract

The invention belongs to the field of research and development of traditional Chinese medicines and particularly relates to a Chinese medicinal formulation containing effective fractions for treating cerebrovascular diseases. The Chinese medicinal formulation is developed based on the compatibility theory of traditional Chinese medicine in combination with the modern pharmacodynamic screening and implemented by composition-effectiveness relationship, component compatibility, optimum design and modern pharmaceutical techniques. The Chinese medicinal formulation contains Radix Paeoniae Rubra effective fraction (total glycosides of Radix Paeoniae Rubra) and Herba Erigerontis effective fraction (total flavonoids and total caffeates of Herba Erigerontis) and is characterized and advantageous in synergistic effect. The pharmacodynamic experimental result shows that the Chinese medicinal formulation can improve cerebral ischemia, increase the brain blood flow, and inhibit platelet aggregation, and is superior in protection against cerebral ischemia to the similar products available in the market.

Description

technical field [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and specifically relates to a Chinese medicine preparation with effective components for preventing and treating cerebrovascular diseases. Compatible prescription with total caffeic acid ester, and provide the preparation method of the traditional Chinese medicine preparation and its application in the treatment of cerebrovascular diseases. Background technique [0002] Cerebrovascular disease is a common and frequently-occurring disease that seriously endangers human health, and has become the first cause of disability and the third cause of death in the world. Compared with the high morbidity rate, high mortality rate and high disability rate of stroke, there are few drugs for the prevention and treatment of stroke at present, which cannot meet the clinical needs; the clinical treatment of cerebral infarction in western medicine still stays at symptomatic...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/28A61P7/02A61P9/10
Inventor 兰燕宇王永林郑林王爱民李勇军黄勇何迅廖尚高肖婷婷傅晓钟刘丽娜周雯刘童董丽李靖董永喜
Owner GUIYANG MEDICAL UNIVERSITY
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