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Medicine for regulating blood fat and treating cardiocerehral disease and preparing method

A technology for cardiovascular and cerebrovascular diseases and blood lipid regulation, which is applied to cardiovascular system diseases, metabolic diseases, drug combinations, etc., can solve the waste of medicinal plant resources, the stems and leaves of Panax notoginseng have not been fully developed and utilized, and only focus on the collection of Panax notoginseng And other issues

Inactive Publication Date: 2005-05-18
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main production area of ​​Panax notoginseng is in Wenshan, Yunnan, and there are thousands of tons of Panax notoginseng stems and leaves every year. However, drug farmers generally only pay attention to the collection of Panax notoginseng, and neglect the stems and leaves of Panax notoginseng. valuable medicinal plant resources

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Get the ginsenoside Rb that weight percent is 22%, purity is 90% 3 and the pharmaceutical excipients of the remainder, according to the conventional capsule manufacturing process, ginsenoside Rb 3 Capsules, each capsule contains ginsenoside Rb 3 50~60mg.

[0033] The ginsenoside Rb 3 Prepared by the following process steps:

[0034] Grind the stems and leaves of Panax notoginseng, reflux or cold soak them with 50-70% ethanol for 2-3 times, each time for 1-3 hours, filter, take the filtrate and concentrate it into an extract, add 2 times the weight of water, and precipitate Chlorophyll, filtered, put the filtrate on a 101 macroporous adsorption resin column, washed with water until colorless, eluted with ethanol gradient, collected 50-70% ethanol eluate, decolorized on a neutral alumina column, concentrated to no ethanol, added 2 Extract with twice the amount of n-butanol, decolorize with activated carbon whose weight is 2% of the n-butanol extract, concentrate and ...

Embodiment 2

[0037] Get the ginsenoside Rb that the percentage by weight is 1.2%, the purity is 90% 3 and the pharmaceutical excipients of the balance, according to the conventional granule manufacturing process, ginsenoside Rb 3 Granules, each bag contains ginsenoside Rb 3 50~60mg.

[0038] The ginsenoside Rb 3 Prepared by the above process steps.

Embodiment 3

[0040] Get the ginsenoside Rb that weight percent is 22%, purity is 90% 3 and the pharmaceutical excipients of the balance, according to the conventional tablet manufacturing process, ginsenoside Rb 3 Tablets, each containing ginsenoside Rb 3 50~60mg.

[0041] The ginsenoside Rb 3 Commercially available.

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PUM

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Abstract

The present invention relates to a kind of medicine prepared with effective components extracted from natural plant medicine materials and for treating cardiac and cerebral vascular diseases and its preparation process. The medicine consists of gensenoside Rb3 in 1-90 wt% and medicinal supplementary material the rest. The medicine is prepared into tablet, coated tablet, oral controlled release preparation, capsule, etc. and is used in treating hyperlipemia, atherosclerosis, coronary heart disease and other cardiac and cerebral vascular diseases.

Description

technical field [0001] The invention relates to a medicament for regulating blood fat and treating cardiovascular and cerebrovascular diseases made from monomer components extracted from natural plant medicinal materials and a preparation method thereof. Background technique [0002] The stems and leaves of Panax notoginseng are the stems and leaves of the Araliaceae plant Panax notoginseng (Burk.) F.H.Chen. The main production area of ​​Panax notoginseng is in Wenshan, Yunnan, and there are thousands of tons of Panax notoginseng stems and leaves every year. However, drug farmers generally only pay attention to the collection of Panax notoginseng, and neglect the stems and leaves of Panax notoginseng. valuable medicinal plant resources. In recent years, scholars at home and abroad have conducted extensive research on Panax notoginseng, and found that the stems and leaves of Panax notoginseng contain a large amount of protopanaxadiol saponins, mainly ginsenoside Rb 1 , Rb ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P3/06A61P9/06A61P9/10
Inventor 王作祥韩金玉杨曙锋包广雷杨和金
Owner YUNNAN INST OF MATERIA MEDICA
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