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Glucoside compound preparation and its preparing process

A compound and glycoside technology, which is applied in the field of preparation and preparation of glycoside compounds, can solve the problems of high saponin content in water extract, low saponin extraction rate, poor solubility and the like

Inactive Publication Date: 2004-12-29
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Recently published patent CN 1168383A, the patent application document discloses a preparation method of the extract: direct extraction with hot water, and then combined extraction of ginseng, American ginseng saponins and polysaccharides with ethanol precipitation, because they only used water for one step of extraction, The extraction rate of poorly soluble saponins in ginseng and American ginseng is low, and the content of saponins in the water extract is high, which makes the separation of saponins and polysaccharides difficult and requires a large amount of ethanol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] 70kg of dried American ginseng roots from Canada, 20kg of dried astragalus from Hebei, and 10kg of dried Sanqi from Yunnan, crush them together, add 80% ethanol solution, and the solid-to-liquid ratio is the volume ratio of the weight of all dried medicinal materials to the 80% ethanol solution 1:8 at 1.5m 3 In the reaction kettle, reflux reaction under boiling state for 6 hours, reflux reaction twice, and the combined filtrate becomes about 1450 liters of mother liquor (1); add 10 kg of dried Chinese wolfberry produced in Ningxia and extraction slag, extract with hot water, the solid-liquid ratio is all The weight ratio of dry medicinal materials to water is 1:10, at 1.5m 3 In the reactor, reflux reaction under boiling state for 6 hours, after cooling, filter out about 760 liters of water extract with a plate and frame filter press, concentrate to about 100 liters, add 100 liters of 80% ethanol solution for precipitation, filter out the precipitate, Dried and pulveriz...

Embodiment 2

[0014] 70g of domestic American ginseng dried ginseng roots, 20g of dried Astragalus membranaceus produced in Hebei, and 10g of dried Panax notoginseng produced in Yunnan, were crushed together, and 80% ethanol solution was added. 1:8, in a 2-liter flask, reflux reaction for 4 hours in a boiling state, reflux reaction twice, and combine the filtrate to form a mother liquor (1) of about 1.4 liters; add 10 g of dried wolfberry produced in Ningxia and the extraction residue, and extract with hot water , the solid-to-liquid ratio, that is, the weight ratio of the weight of all dry medicinal materials to water is 1:10. In a 2-liter flask, the boiling state was refluxed for 4 hours. After cooling, about 740 milliliters of the water extract was filtered out and concentrated to about 100 ml, add 100 ml of 80% ethanol solution for precipitation, filter out the precipitate, dry, and pulverize to obtain 5.25 g of water-soluble mixed polysaccharide, which is a kind of glycoside compound wi...

Embodiment 3

[0016] 70g of domestic dried ginseng roots, 20g of dried Radix Astragali from Hebei, and 10g of dried Radix Notoginseng from Yunnan, pulverize together, add 80% ethanol solution, and the solid-to-liquid ratio is the volume ratio of the weight of all dry medicinal materials to the 80% ethanol solution. 1:8, in a 2-liter flask, reflux reaction for 4 hours in a boiling state, reflux reaction twice, combine the filtrate to become a mother liquor (1) of about 1.4 liters, add 10 g of dried Lycium barbarum produced in Ningxia and the extraction residue, and extract with hot water , the solid-to-liquid ratio, that is, the weight ratio of the weight of all dry medicinal materials to water is 1:10. In a 2-liter flask, the boiling state was refluxed for 4 hours. After cooling, about 720 milliliters of the water extract was filtered out and concentrated to about 100 ml, add 100 ml of 80% ethanol solution for precipitation, filter out the precipitate, dry, and pulverize to obtain 4.86g of w...

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Abstract

The present invention is one kind of glycoside preparation and its preparation process. The glycoside preparation is prepared with American ginseng and / or ginseng, astragalus root and notoginseng as material and through extraction with ethanol solution in certain concentration and other steps. The glycoside preparation has the functions of refreshing, improving memory, promoting blood circulation to disperse blood clots, lowering blood sugar and pressure, preventing cardiac and cerebral vascular diseases, etc.

Description

technical field [0001] The invention relates to a glycoside compound preparation and a preparation method, in particular to a glycoside compound preparation and a preparation method using American ginseng and / or ginseng, astragalus and Panax notoginseng as raw materials. Background technique [0002] American ginseng or ginseng, astragalus and notoginseng are commonly used rare and precious Chinese medicinal materials. These three medicinal materials are mainly used as medicines from underground roots or root hairs. Especially American ginseng or ginseng, usually people take it directly after stewing with water or directly take American ginseng or ginseng in finely ground capsules. In fact, American ginseng or ginseng contains two types of active ingredients: American ginseng or ginsenosides, American ginseng or ginseng polysaccharides; astragalus contains three types of active ingredients: astragaloside, astragalus Qisu and Panax notoginseng polysacch...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/7048A61P3/06A61P3/10A61P9/10A61P9/12A61P25/00
Inventor 池汝安
Owner WUHAN INSTITUTE OF TECHNOLOGY
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