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General glycoside extract from tree peony root bark and its preparation method and uses thereof

A technology of extract and paeonol glycosides, applied in the field of total paeonol glycosides extract and its preparation, can solve the problems of unstable ingredient content, unfavorable popularization and application, difficulty in meeting drug quality stability and multi-dosage application development

Inactive Publication Date: 2006-06-21
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chinese patent CN1418673A provides a preparation method of total paeonol glycosides, the total paeonol glycosides prepared according to the method, the composition is complex, in addition to containing paeoniflorin components, also contains volatile components paeonol and other Impurity ingredients, unstable ingredient content, and poor water solubility, it is difficult to meet the requirements of stable drug quality and multi-dosage application development
Chinese patent CN1420122 provides the method for preparing paeoniflorin monomer, but the preparation method is very complicated, which is not conducive to the popularization and application in industry

Method used

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  • General glycoside extract from tree peony root bark and its preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Preparation of total paeony glucosides

[0017] Take 20kg of paeonol medicinal material (place of origin: Tongling), crush it into coarse powder, put it into an extraction tank; add 200L of water and boil it for 2 times, each time for 2h, after filtering, concentrate under reduced pressure to about 30L; use AB-8 type Macroporous adsorption resin column, fully eluted with water until the effluent was clear and free of reducing sugar reaction, then eluted with 40% ethanol; collected eluate, concentrated under reduced pressure, extracted twice with chloroform, recovered chloroform, and added 95% % ethanol to make the alcohol concentration 80%. Let it stand for 0.5h, filter off the precipitate, and recover the filtrate to dryness under reduced pressure to obtain 1 kg of paeonol glycosides raw material. The content of total glycosides in the total glycosides of paeony in the effective part was detected by HPLC to be 66%, and the content of paeoniflorin as the ...

Embodiment 2

[0018] Embodiment 2: Preparation of total paeony glycosides freeze-dried powder injection

[0019] Under clean conditions, take 50g of refined total paeony glycosides, add appropriate amount of water for injection to dissolve, stir to dissolve, and ultra-filter to obtain a pyrogen-free clear liquid, add water for injection to 1000ml, subpackage into 1000 tubes, press freeze-dried powder injection The process is freeze-dried to make a freeze-dried powder containing 50 mg of total paeony glycosides.

Embodiment 3

[0020] Embodiment 3: preparation paeony total glucosides capsule

[0021] Take 100g of the above-mentioned total paeonol glycosides raw material, 50g of starch, and 100g of β-cyclodextrin, mix evenly, granulate, sieve, dry and pack into 1000 capsules (100mg / capsule).

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Abstract

The present invention provides one kind of total paeonoside extract and its preparation process as well as the application of the total paeonoside extract in preparing medicine for preventing and treating cardiac and cerebral vascular diseases. Specifically, the total paeonoside extract is used in preparing medicine for preventing and treating cerebral apoplexy, cerebral ischemia / re-perfusion damabe, brain trauma, senile dementia, etc.

Description

technical field [0001] The invention relates to an extract of total paeony glycosides and a preparation method thereof, as well as the application of the total paeony glycosides extract in the preparation of medicines for treating or preventing cardiovascular and cerebrovascular diseases. Background technique [0002] Cortex Moutan, also known as Cortex Moutan, Bark Fen, Paeoniae Alba, Cortex Tiaodan, and Luoyang Flower, is the root bark of Paeoniae genus Paeoniae in the family Ranunculaceae. It is used for warm-toxin-induced spots, vomiting, bleeds, blood in the stool, bone steaming and labor-heat, amenorrhea dysmenorrhea, carbuncle sores, and pain caused by tumbling. Cortex Moutan contains paeoniflorin, benzoylpaeoniflorin, paeonol glycoside, paeonol protoside, paeonol, benzoic acid, volatile oil, sugar and sterol and other ingredients. Studies have found that paeoniflorin has pharmacological effects such as expanding coronary arteries, increasing coronary flow, resisting...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/08A61K9/10A61K9/14A61K9/20A61K9/48A61P9/00A61P9/04A61P9/10
Inventor 高玉白王超云张太平孙芳
Owner SHANDONG LUYE PHARMA CO LTD
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