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Shallot extract as well as preparation method and usage thereof

A technology of extract, onion, applied in the field of medicine

Inactive Publication Date: 2008-05-21
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the extract of onion and its use in the prevention and treatment of myocardial ischemic cardiovascular disease

Method used

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  • Shallot extract as well as preparation method and usage thereof
  • Shallot extract as well as preparation method and usage thereof
  • Shallot extract as well as preparation method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 onion extract

[0021] After 10 kg of dried shallots are crushed, they are put into an extraction tank, boiled and extracted three times with 50 liters of pure water at 90-100°C, each extraction time is 1 hour, the three extractions are combined, concentrated to 20 liters, centrifuged, filtered, discarded To remove the precipitate, the supernatant was adjusted to 50 liters with distilled water. Slowly pass through an adsorption column equipped with 6 kg of polystyrene porous adsorption macroporous resin, rinse with 80 liters of distilled water to remove impurities; then elute with 50 liters of 50% aqueous ethanol, collect the eluate, concentrate to dryness, and further Dried and pulverized to obtain 0.09 kg of yellow powdered shallot extract, with a recall rate of 0.9% according to crude drug amount.

Embodiment 2

[0022] Therapeutic effect of embodiment 2 onion extracts on canine acute myocardial ischemia

[0023] In this experiment, anesthetized dogs were administered intragastrically with different doses of onion extract to observe its improvement and therapeutic effect on acute myocardial ischemia.

[0024] 1 Materials and methods

[0025] 1.1 Experimental animals

[0026] Healthy mongrel dogs (provided by the Animal Center of the Second Military Medical University, animal breeding certificate number: SCXK (Shanghai) 2002-0006; gender: both male and female; weight: 9-14kg; 5 dogs per group; total number of animals: 25 dogs)

[0027] 1.2 Administration method

[0028] Administration method: intragastric administration

[0029] Dosage: The low, medium and high doses of dogs are 15mg / kg (equivalent to 1.9g / kg of the original drug), 45mg / kg and 90mg / kg respectively; the positive control Xingling Granules is 300mg / kg (equivalent to ginkgo ketone ester 15mg / kg); normal saline is given ...

Embodiment 3

[0059] Example 3 Protective effect of Semen scallion extract on myocardial ischemia-reperfusion injury in rats

[0060] In this experiment, different doses of onion extract were given to rats by intragastric administration to observe its protective effect on myocardial ischemia-reperfusion injury in rats.

[0061] 1 Materials and methods

[0062] 1.1 Test animals

[0063] Sprague-Dawley rats (provided by the Animal Center of Shanghai Branch of the Chinese Academy of Sciences; animal certificate number: SCXK (Shanghai) 2002-0010; grade: clean grade, certificate number: Yidongzi No. 02-64; body weight: 250-300g ;Sex: female; 10 per group; total: 60)

[0064] 1.2 Administration method

[0065] Administration method: intragastric administration

[0066] Dosage: Low, medium and high doses for rats are 50mg / kg, 150mg / kg and 300mg / kg respectively. The dose of positive drug is 900mg / kg (equivalent to 45mg / kg of ginkgo ketone ester)

[0067] Dosing frequency: all single administr...

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Abstract

The invention belongs to the field of medical technology, in particular to a scallion seed extract and the preparation method, as well as the application of the scallion seed extract on the preparation of the medicine or the food for preventing and curing cardiac muscle ischemic cardiovascular disease. In recent years, the studies on the scallion mainly focus on the cardiovascular pharmacological action of the whole scallion. The invention aims to provide an effective part, namely the scallion seed extract which is used for preventing and curing myocardial ischemia. The scallion seed extract is formed by the following steps: extracting solution is thermally extracted from scallion seed medicinal materials by aqua pura, the extracting solution is separated by macropore polymeric adsorbents, and then the scallion seed extract can be obtained by refining. Proved by the experiments on animals, the scallion seed extract can obviously relieve the myocardial ischemia of the animal models, and reduce infarct region; moreover, the invention also can prevent ischemia reperfusion injury, and can obviously narrow the area of miocardial infarction. Therefore, the invention scallion seed extract can prevent and cure cardiac muscle ischemic cardiovascular disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a shallot extract and a preparation method thereof, as well as the use of the shallot extract in preparing medicine or food for preventing and treating myocardial ischemic cardiovascular disease. Background technique [0002] Myocardial ischemia is a type of cardiovascular disease with a relatively high incidence rate. During the attack, the patient feels severe paroxysmal dull pain or colic in the precordial area; when repeated attacks and reperfusion occur, it will also cause myocardial cell damage and heart failure. Functional disorders are mainly manifested as: arrhythmia, vascular injury or even blood retention, loss of myocardial function, accelerated ischemia-induced necrosis of damaged myocardial cells, and myocardial cell edema. In my country, more than 3 million patients die from cardiovascular and cerebrovascular diseases every year, and among the survivin...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P9/10A61K131/00
Inventor 孙连娜陈万生来威邱彦杨阳
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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