44 results about "Caffeic acid phenethyl ester" patented technology

This application involves taking caffeic acid phenethyl ester (CAPE) extracted from natural propolis and having neuroprotective activity as a precursor, and designing a class of sulfone groups instead of ester groups according to the theory of bioelectronic isosterism and hydrogen bonding. The new molecule, its structure is shown in general formula I, and the definition of each group in the formula is as described in the claims. At the same time, it also involves the evaluation of the compound's antioxidant capacity in vitro, the evaluation of neuroprotective activity at the cellular level, and the evaluation of the ability to penetrate the blood-brain barrier. The activity evaluation results showed that the synthesized new compound had enhanced neuroprotective activity and could pass through the blood-brain barrier more easily, thus becoming a new type of neuroprotective agent for treating neurodegenerative diseases.

The invention discloses o-nitro caffeic acid phenethyl ester with a structural formula shown as formula I. The method includes: subjecting caffeic acid and thionyl chloride to acylation reaction to generate caffeoyl chloride, then in the presence of a catalyst, subjecting the caffeoyl chloride and o-nitrophenylethanol to esterification reaction in an organic solvent, thus obtaining o-nitro caffeic acid phenethyl ester. Compared with caffeic acid phenethyl ester, the o-nitro caffeic acid phenethyl ester has better effect of protecting antioxidant enzyme activity, stronger ability of clearing oxygen free radicals, and better effects of maintaining antioxidant ability of myocardial cells, protecting normal cell structure and alleviating cell oxidative damage, can significantly reduce ischemia / reperfusion myocardial cell apoptosis, decreases myocardial infarction area, can be used for preparation of drugs for improving ischemia reperfusion injury, and plays an important role in treatment of cardiovascular system diseases. (formula I).

The invention provides a preparation method of a molecularly imprinted polymer capable of enriching caffeic acid phenethyl ester. The molecularly imprinted polymer capable of enriching the caffeic acid phenethyl ester can be prepared through uniformly mixing, nitrogen-blow deoxidization, constant temperature water bath reaction, soxhlet extraction and drying with the caffeic acid phenethyl ester as a template molecule, a mixed solvent of tetrahydrofuran and isooctane as a pore-forming agent, 4-vinyl pyridine as a functional monomer, ethylene glycol dimethacrylate as a crosslinking agent and azodiisobutyronitrile as an initiator. The invention has the advantages that the prepared molecularly imprinted polymer capable of enriching the caffeic acid phenethyl ester has the advantages of simple synthesis, low cost, strong specificity, long service life and the like, can be used for separating and extracting the caffeic acid phenethyl ester from a natural product, in particular to natural products with low caffeic acid phenethyl ester content, and the molecularly imprinted polymer reaches the purposes of enrichment and purification.

A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product.

The invention provides a new purpose of caffeic acid and derivatives thereof in preparing drugs of cranial nerves protective agent, wherein caffeic acid methyl ester, caffeic acid ethyl ester and 3, 4-diacetyl caffeic acid obtained by taking the caffeic acid as a raw material which is subject to structural modification have the obvious protective activity for the cranial nerves; the caffeic acid methyl ester and the 3, 4-diacetyl caffeic acid can penetrate a blood brain barrier and directly reaches to a target organ; and the derivatives are ideal candidate medicines of the cranial nerves protective agent.