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New purpose of caffeic acid and derivatives thereof

A derivative, caffeic acid technology, applied in the field of new applications of caffeic acid and its derivatives

Inactive Publication Date: 2012-03-07
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Caffeic acid mainly has antibacterial, antiviral, central excitatory, detoxifying, blood coagulation effects, and caffeic acid and its derivatives also have antioxidant effects, but there is no relevant report about caffeic acid and its derivatives being used as brain neuroprotective agents.

Method used

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  • New purpose of caffeic acid and derivatives thereof
  • New purpose of caffeic acid and derivatives thereof
  • New purpose of caffeic acid and derivatives thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] The preparation of embodiment 1 medicine of the present invention

[0016] Instruments GC / MS-QP5050A gas spectrometer (Shimadzu), SOR37 Fourier transform infrared spectrometer (BRUKER), nuclear magnetic resonance instrument is the same as Chapter 2, XW-80A vortex mixer (Shanghai Qingpu Huxi Instrument Factory), Digital display constant temperature water bath (Jincheng Guosheng Experimental Instrument Factory), R-124 rotary evaporator (BUCHI), SHZ-D circulating water vacuum pump (Gongyi Yuhua Instrument Factory), YP202N electronic balance (Shanghai Precision Science Instrument Co., Ltd.), etc.

[0017] Reagents Anhydrous methanol, absolute ethanol, phosphoric acid, acetic anhydride, concentrated sulfuric acid, ethyl acetate, calcium carbonate, n-octanol, sodium bicarbonate, etc. (all analytically pure, Chongqing Chuandong Chemical Co., Ltd. Chemical Reagent Factory), column Chromatographic silica gel (100~200 mesh, Qingdao Ocean Chemical Factory)

[0018] Reagent Caffe...

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Abstract

The invention provides a new purpose of caffeic acid and derivatives thereof in preparing drugs of cranial nerves protective agent, wherein caffeic acid methyl ester, caffeic acid ethyl ester and 3, 4-diacetyl caffeic acid obtained by taking the caffeic acid as a raw material which is subject to structural modification have the obvious protective activity for the cranial nerves; the caffeic acid methyl ester and the 3, 4-diacetyl caffeic acid can penetrate a blood brain barrier and directly reaches to a target organ; and the derivatives are ideal candidate medicines of the cranial nerves protective agent.

Description

technical field [0001] The present invention relates to the new application of caffeic acid and its derivatives. Background technique [0002] Apoplexy, also known as apoplexy, is characterized by sudden fainting, hemiplegia, crooked tongue, awkward speech or numbness in one side of the body, and has the characteristics of rapid onset and rapid change. Disease is a common and frequently-occurring disease among middle-aged and elderly people, which seriously threatens the survival and health of human beings. This disease is equivalent to Ischemic Cerebral vascular Disease (ICVD) in Western medicine, also known as ischemic stroke, which has a high mortality rate and disability rate, and seriously threatens human health and life safety ( Rao Mingli, Lin Shihe. Cerebrovascular Diseases. People's Health Publishing House, 2002.172). As a common and frequently-occurring disease, ICVD, especially limited cerebral infarction, has been listed as the third leading cause of death in m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K31/216A61K31/222A61P25/00A61P9/10
Inventor 张艺孟宪丽张静
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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