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New application of scutellarin and derivatives thereof

A technology of scutellarin ethyl ester and its use, applied in the field of scutellarin and its derivatives

Inactive Publication Date: 2012-05-30
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

(Cui Jianmei, Wu Song. Research progress of scutellarin [J]. Natural product research and development, 2003, 15 (3): 255; Wan Lili, etc., research progress of scutellarin pharmacokinetics, "Chinese Pharmacy", 2007, Volume 18, Issue 30) There is no relevant report on the use of scutellarin and its derivatives in brain neuroprotective agents

Method used

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  • New application of scutellarin and derivatives thereof
  • New application of scutellarin and derivatives thereof
  • New application of scutellarin and derivatives thereof

Examples

Experimental program
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Embodiment 1

[0019] The preparation of embodiment 1 medicine of the present invention

[0020] Simultaneously, a simple structural modification of scutellarin was carried out to obtain scutellarin aglycon (scutellarein) and scutellarin ethyl ester.

[0021] Materials and instruments: scutellarin (provided by Yuxi Wanfang Natural Medicine Co., Ltd., self-made and purified, mainly containing scutellarin, the content is greater than 95%)

[0022] GC / MS-QP5050A gas spectrometer (Shimadzu), SOR37 Fourier transform infrared spectrometer (BRUKER), nuclear magnetic resonance instrument is the same as Chapter 2, XW-80A vortex mixer (Shanghai Qingpu Huxi Instrument Factory), digital Shown constant temperature water bath (Jincheng Guosheng Experimental Instrument Factory), R-124 rotary evaporator (BUCHI), SHZ-D circulating water vacuum pump (Gongyi Yuhua Instrument Factory), YP202N electronic balance (Shanghai Precision Scientific Instrument Ltd.) etc.

[0023] Reagents Anhydrous methanol, absolute...

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Abstract

The invention provides application of scutellarin and derivatives thereof in the preparation of cranial neuroprotective agents. Taking scutellarin as raw material, structure modification is carried on to obtain apigenin and glycolamide ester of scutellarin, which have obvious cranial neuroprotective activities, and glycolamide ester of scutellarin can permeate the blood-brain barrier to directly reach the target organs, thus being an ideal drug candidate of cranial neuroprotective agents.

Description

technical field [0001] The present invention relates to the new application of scutellarin and its derivatives. Background technique [0002] Apoplexy, also known as apoplexy, is characterized by sudden fainting, hemiplegia, crooked tongue, awkward speech or numbness in one side of the body, and has the characteristics of rapid onset and rapid change. Disease is a common and frequently-occurring disease among middle-aged and elderly people, which seriously threatens the survival and health of human beings. This disease is equivalent to Ischemic Cerebral vascular Disease (ICVD) in Western medicine, also known as ischemic stroke, which has a high mortality rate and disability rate, and seriously threatens human health and life safety ( Rao Mingli, Lin Shihe. Cerebrovascular Diseases. People's Health Publishing House, 2002.172). As a common and frequently-occurring disease, ICVD, especially limited cerebral infarction, has been listed as the third leading cause of death in mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/352A61P25/00A61P9/10
Inventor 张艺孟宪丽张静
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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