Phenethyl caffeate analogue and preparation and application thereof

Abstract

The invention relates to a phenethyl caffeate analogue and preparation and an application thereof in the technical field of medicines. The chemical structure of the phenethyl caffeate analogue is as follows. The method is simple and feasible, higher in yield and suitable for industrialized production on a large scale. The phenethyl caffeate analogue obtained has stronger biological activity and lower effective concentration. Particularly, a compound chlorophenethyl ethyl ester caffeate has a prospect of being developed as a medicine for preventing and treating neurodegenerative diseases.

Description

technical field [0001] The present invention relates to a method and a compound in the technical field of medicine, in particular to a caffeic acid phenethyl ester analogue and its preparation and application. Background technique [0002] A neurodegenerative disease is a disease that progressively affects the function of the nervous system, especially the brain. The disease is caused by the degeneration and loss of neurons or their myelin sheath, which worsens over time and leads to dysfunction, often irreversibly. Affected by the disease, patients will have varying degrees of impairment symptoms such as memory, perception, language ability, judgment and motor ability. Common neurodegenerative diseases include Parkinson's disease, Alzheimer's disease, Huntington's disease, etc. With the arrival of the aging population in the world, the incidence of neurodegenerative diseases is increasing year by year, and has become a serious disease that threatens the health of the elde...

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Problems solved by technology

Chinese Patent Document No. CN101993376A also discloses caffeic acid p-nitrophenylethyl ester compound and its therapeutic effect on leukopenia, but caffeic acid p-nitrophenylethyl ester itself has no report on neurodegenerative diseases

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