The invention provides a display screen design method and device, and the method comprises the steps: determining a first grid line disposed between a first pixel and a second pixel in a target display screen, enabling the area of the first pixel to be larger than that of the second pixel, enabling the first pixel to be adjacent to the second pixel, and according to a first preset shielding view angle, determining a first interval between the first pixel and the first grid line, the first interval being smaller than a second interval between the second pixel and the first grid line, and then determining the position of the first grid line between the two pixels according to the first interval, i.e., adjusting the position of the first grid line, so that the grid line is close to the pixelwith a larger area, and the pixel with a larger area is obtained. The grid lines are separated from the pixels with smaller areas, so that the shielding of the grid lines to the pixels with differentsizes is approximately consistent, the color cast phenomenon of a large viewing angle is improved, the thickness of the packaging layer is not changed, the product performance is not reduced, the width of the grid lines is not changed, and the process difficulty is not increased.