The invention provides an integrated circuit protection structure and a manufacturing method thereof. The integrated circuit protection structure comprises at least one ring of annular structure, wherein the annular structure comprises a first interconnection layer, a through hole layer and a second interconnection layer, wherein the first interconnection layer comprises at least one conductive part; the through hole layer comprises at least one conductive through hole, wherein the conductive through hole is connected to the upper portion of the conductive part, and the center of the conductive through hole deviates from the center of the conductive part; and the second interconnection layer comprises at least one conductive wire, wherein the conductive wire is connected above the conductive through hole. The asymmetric design is adopted for the axial symmetric design, wherein the center of the conductive through hole is deviated from the center of the lower-layer conductive part through transverse displacement, so that the conductive through hole completely or partially avoids the part of a hole of the lower conductive part, the conductive through hole can be effectively filled, the high-quality and reliable functions of a sealing ring, a protection ring and the like are facilitated, and influence to the later process is avoided. In addition, by adopting the scheme of the invention, the additional process cost is not increased.