The invention discloses a nano wood-imitating floor and a manufacturing method thereof. The floor comprises, by weight, 2-6 parts of diatomite, 1-3 parts of nano silicon dioxide, 0.1-1 part of zirconia, 0.1-1 part of zinc oxide, 5-15 parts of titanium dioxide powder, 0.1-1 part of silver oxide, 10-30 parts of magnesium chloride, 10-30 parts of magnesium oxide and 2-4 parts of modifiers. By combining the functional materials, the functions of environment friendliness, attractive appearance, sterilizing, mosquito repelling, cockroach repelling, ant repelling, fire preventing, damp preventing, weather resistance, no deformation, no formaldehyde, recovery-reuse and no pollution of the wood-imitating floor are achieved, the performance of an existing wood-imitating floor can be optimized greatly, and profound historical significance and market value are achieved. The manufacturing method of the wood-imitating floor is simple in technology process, low in equipment requirement and high in operability and can be applied and popularized widely.