Devices, systems, kits and methods for increasing the
skin's permeability controlled by measured
skin electrical parameter are described herein. They may be used for transdermal
drug delivery and / or
analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an
abrasive tip, (iii) a
feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The
feedback control mechanism may be an
internal feedback control mechanism or an external
feedback control. The kit contains the controlled abrasion-device, one or more
abrasive tips, optionally with a
wetting fluid. The method for increasing the
skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a
drug delivery composition or device or an
analyte sensor is applied to the treated site.