The invention discloses an express delivery industry false picking preventing package box capable of being repeatedly used. The express delivery industry false picking preventing package box comprises a box body, a label plate, a fixed bonding plate, a top cover, a movable bonding plate, a strip-shaped code frame, a delivery note pasting plate, an inner cover, an interlayer, a dampproof layer and a buffering layer. The express delivery industry false picking preventing package box is characterized in that the box body is a rectangular box body, the label plate is arranged on the side face of the box body and used for a courier to number express deliveries, the label plate can be scrubbed, and the fixed bonding plate is fixed to the lower portion of the front side face of the box body; the top cover is connected with the rear edge of the box body, the top cover is provided with the rectangular strip-shaped code frame, and the movable bonding plate is connected to the front edge of the top cover; the inner cover is arranged below the top cover; the independent interlayer is arranged below the inner cover and covers an upper opening in the box body, and the interlayer is mainly used for preventing the tops of goods from being subjected to collisions; and the dampproof layer preventing the goods from getting damp is arranged on the inner edge of the box body, and the corrugated buffering layer protecting the goods against collisions is arranged on the inner side of the dampproof layer.