106results about How to "Improve activation ability" patented technology

The invention provides a CD19 targeted CAR (chimeric antigen receptor)-T cell, a preparation method and an application and relates to the field of immune cells. The activation capacity of T cells in CAR-T cell therapy can be improved, the problem of insufficient transfection efficiency can be solved, and the CAR-T cell has a high killing capacity for CD19. The CD19 targeted CAR-T cell expresses a CD19 targeted CAR gene on surface, and the CD19 targeted CAR gene is formed by connecting a single-chain antibody CD19ScFv of CD19, a hinge region and a transmembrane region of CD8, an intracellular signal structure of CD28, an intracellular signal structure of 4-1BB and an intracellular signal structural domain of CD3zeta in series, and the base sequence of the CD19 targeted CAR gene is shown as SEQ ID NO:2.

The invention provides a graphene modified composite mesoporous carbon microsphere air purifying preparation. A certain amount of beta-cyclodextrin is added to thin-layered nano-SiO2 particles covering the surfaces of obtained micro-SiO2 particles, a certain quantity of obtained RGO/TiO2 nanoparticles is added simultaneously, -OH, -COOH, C-O-C and C=O oxygen-containing functional groups rich on the surface of graphene are adsorbed by and bonded with the RGO/TiO2 nanoparticles on the basis of the molecular recognition characteristic of beta-cyclodextrin, then a certain amount of CTAB (cetyltrimethylammonium bromide) surfactant is added, CTAB serving as a micelle stabilizer can stop the RGO/TiO2 nanoparticles from further hydrolysis and growth, and finally, the novel air purifying preparation adopting RGO/TiO2 supported by carbon microspheres with a mesoporous shell structure is obtained. With adoption of the scheme, the purity is high, RGO/TiO2 supported by the carbon microspheres with the mesoporous shell structure in powder is better in bonding performance, uniform in distribution and controllable in dimension at mesopores, and the air purifying preparation can be used for purifying polluted air and removing dust in a haze environment as well as photo-catalytically degrading and separating nitric oxide, sulfide or other organic pollutants in the polluted air.

The invention relates to a preparation process of a dual-metal engine cylinder composite material, the preparation process comprises the following steps of: firstly, acid-washing a HT250 cast iron cylinder liner and carrying out surface degreasing and derusting treatment on the HT250 cast iron cylinder liner; then dipping the HT250 cast iron cylinder liner into a prepared proportional saline solution, so that the surface of the HT250 cast iron cylinder liner is soaked in the saline solution; then drying the HT250 cast iron cylinder liner, and putting the HT250 cast iron cylinder liner in a ZL101A aluminum alloy melt body for hot immersion plating; fixing the immersion-plated HT250 cast iron cylinder liner in a mold cavity of a metal mold casting mold, casting, melting and cooling a ZL101A aluminum alloy, wherein concentration of the saline solution is 100-200g/L, the saline solution is prepared by mixing water together with potassium fluoride KF, potassium chloride KCl, sodium chloride NaCl, calcium fluoride CaF2, and calcium chloride CaC12 according to a mass ratio of 39-46:16-26:15-21:6-15:5-10. According to the preparation process, the engine cylinder composite material is obtained through treating the ZL101A aluminum alloy and HT250 cast iron by a self-prepared surfactant and implementing a dual-metal composite casting process on the ZL101A aluminum alloy and the HT250 cast iron, wherein two metal materials of the ZL101A aluminum alloy and the HT250 cast iron are not mixed and kept with original physical properties; but the ZL101A aluminum alloy and the HT250 cast iron obtain an extremely perfect combination interface, so that casting metallurgical bonding of 99.5 percent and above is achieved.

The invention discloses a mixing synergist capable of improving the utilization rate of a rice fertilizer, and a use method of the mixing synergist, relating to the technical field of fertilizers used by rice planting. The mixing synergist is prepared by the following raw materials in parts by weight: 1-3 parts of a urease inhibitor, 1-2 parts of a long-acting compound fertilizer additive, 0.5-1.2 parts of a synergist, and 0.5-1 part of nano carbon. The mixing synergist has the characteristics of improving the utilization rate of the rice fertilizer and the grain yield, reducing the flow rate of nitrogen and phosphorus of a farmland to a water body and soil, and controlling the agricultural non-point source pollution generated by the farmland from the source and the like. The mixing synergist capable of improving the utilization rate of the rice fertilizer provided by the invention is a mixing synergist capable of improving the utilization rate of the rice fertilizer and reducing the nitrogen and phosphorus loss, and is suitable for being applied in early and late rice planting.

The invention discloses a quick-setting filling cementing material and a preparation method thereof. The composition comprises the following components in parts by weight: 40-90 parts of slag powder;6-24 parts of cement clinker; 2-18 parts of bentonite, 2-28 parts of steel slag powder; 0-15 parts of modified gypsum; 0.5-10 parts of an alkaline excitant; 0-10 parts of a coagulant; 1-3 parts of a water reducing agent; 0.2-8 parts of an anti-cracking material; and 0.5-10 parts of a suspension agent. The quick-setting filling cementing material can effectively reduce the dosage of an additive, has good flowing property and relatively high early strength, has good retention strength and volume stability, is short in cementing time, quick in early strength increase and slow in later strength increase, and is simple in process and wide in material source.

The method includes following steps: S102 step, optical line terminal (OLT) sends first message to inform new optical network unit (ONU) the relevant parameters in prearranged format needed for activating ONU; S104 step, OLT sends out second message to request obtaining sequence number of ONU demanding to enter to passive optical network in giga bit; step S106, after receiving first response message sent from ONU, OLT assigns a ID for first ONU; S108 step, OLT measures distance to ONU, and returns back to S102 after completing measurement. The invention shortens waiting time for obtaining sequence number of ONU, and simplifies complex degree of algorithm for assigning dynamic bandwidth for OLT in procedure of distance measurement.

The invention provides room-temperature high-plasticity wrought magnesium alloy and a preparation method thereof. The magnesium alloy comprises the following components by weight percent: 5.5wt%-7.3wt% of Al, 0.40wt%-1.50wt% of Zn, 0.15wt%-0.50wt% of Mn, 0.05wt%-1.0wt% of P and the balance being Mg and inevitable impurities, wherein the inevitable impurities comprise the following components: not more than 0.05wt% of Si, not more than 0.004wt% of Fe, not more than 0.004wt% of Cu and not more than 0.002wt% of Ni. According to the magnesium alloy, a nonmetal element P is added in an existing magnesium alloy smelting process, a stable small grain structure is obtained under the action of the nonmetal element P, the room-temperature plasticity is improved, and the room-temperature processing and using requirements of finished products or semi-finished products can be met.

The present invention relates a method for a function test of a distance measurement system which is used for testing transportation facilities, especially, obstacles near vehicles, and has at least one sensor for receiving a reflection of transmitted signals. The present invention prescribes that the sensitivity of the sensor is enhanced at a certain time interval for testing the ground reflections, and the detected ground reflections are compared with each other.

The invention discloses a wear-resistant surface modifier for manganese phosphating and a preparation method thereof. The modifier comprises the following components: 5 to 15wt% of manganese carbonate, 3 to 15wt% of 40% manganous nitrate solution, 1 to 10wt% of disodium hydrogen phosphate, 5 to 15wt% of Na4P2O7, 0.5 to 3wt% of seignette salt, 0.5 to 3wt% of sodium oleate and 0.08 to 0.8wt% of polyvinyl alcohol. The preparation method comprises the following steps: stirring and mixing the measured manganese carbonate, 40% manganous nitrate solution, seignette salt and sodium oleate, adding measured polyvinyl alcohol, carrying out reaction to generate precipitate, drying and grinding the precipitate into powder of 3 to 30 mu m, adding measured Na4P2O7 at weight ratio of (1 to 10): (10 to 1), and completely and uniformly stirring and mixing the mixture.

The invention relates to the technical field of skin care products for daily use, and discloses a lysozyme mask. The lysozyme mask comprises essence, and the essence comprises the following raw material components: 3-5 parts of crude salt, 1-3 parts of lysozyme, 1-2 parts of sodium hyaluronate, 1-2 parts of lotus leaf juice, 1-2 parts of aloe juice and 100-200 parts of deionized water. The mask not only has good effect of removing acne marks and acnes and is good in antibacterial property, but also is non-irritant, and can facilitate rapid healing of a wound.

The invention provides a T1-T2 double-activated magnetic resonance imaging contrast agent as well as a preparation method and application thereof. The T1-T2 double-activated magnetic resonance imagingcontrast agent has a core-shell structure and sequentially comprises T2 contrast agent nanoparticles, a silicon dioxide layer, a T1 contrast agent layer and a modification layer from inside to outside, and the T2 contrast agent nanoparticles are superparamagnetic iron oxide nanoparticles. The T1-T2 double-activated magnetic resonance imaging contrast agent is in a T1 and T2 contrast agent signaldouble-quenching state in normal tissues around an in-vivo tumor, and T1 and T2 contrast agent signals can be activated at the same time at a tumor part, so that the tumor part and the surrounding normal tissues have a remarkable MRI signal difference, and the T1-T2 double-activated magnetic resonance imaging contrast agent has targeting property on tumor cells, so as to realize high-quality imaging for the tumor part.

The invention discloses a plastic electroplating process of vehicle interior panels. Firstly, cracks or flaws are examined on the surfaces of plastic panels or not after injection molding; after examination, the plastic panels are placed in a ventilation place for standing by 24-48 hours; and the placing environment temperature is maintained between 10-30 DEG C, so that the internal stress of partof the plastic panels is reduced. In the plastic electroplating process of the vehicle interior panels, through higher roughening capacity on electroplating-stage ABS plastic, the main effect of chromic acid is to oxidize ABS or butadiene in PC-contained ABS to form anchoring points, so that more hydrophilic polar groups are generated on the plastic surfaces; and due to existence of the groups, the hydrophilia of the plastic surfaces is greatly improved, the chemical bonding is facilitated, the plating layer bonding force is improved, subsequent electroplating metal elements are preferably attached on the surfaces of the plastic panels, the metal fall caused by weakening of the plating layer bonding force after long-time use is prevented, and the advantage of better wear resistance is achieved.

A resin board that consists of at least one of a mixture of a plurality of types of resins having different degrees of susceptibility to erosion by an ozone solution, and a resin having, in a molecule, a plurality of types of components having different degrees of susceptibility to erosion by the ozone solution is treated with ozone water to form a reformed layer, and a catalyst metal is adsorbed by the reformed layer so as to form a resin-metal composite layer, on which a plating process is performed. In the resin board, a component or components that is/are likely to be eroded on by the ozone solution dissolves into the ozone solution, and pores or clearances on the order of nanometers are formed between the component(s) and a component or components that is/are less likely to be eroded by the ozone solution. With the plating deposited in the pores or clearances, the adhesion strength is improved due to an anchoring effect. Thus, the adhesion strength of the plating film is improved even where the resin-metal composite layer has a thickness of 10 to 200 nm.