125results about How to "High fatality rate" patented technology

The invention discloses a fluorocyanogen-containing pyrethroid compound and a synthesis method and an application thereof, which belong to the technical field of organic pesticides. The compound has a general structural formula (I) shown as the accompanying drawing, and in the general structural formula (I), R represents compounds applicable to the alcohol part contained in the conventional pyrethroid, which also include various stereoisomer forms thereof and the mixture of various stereo-configured compounds thereof. The invention also relates to an active component containing the fluorocyanogen-containing pyrethroid compound (I), which is used as an effective agent for controlling harmful insects, and a method for producing the ester compound (I). The invention discloses the application of the compound and a pesticidal mixture containing the compound as the active component in controlling pests.

The invention relates to a multiplex PCR (polymerase chain reaction) primer, a probe and a gene chip for detecting the bluetongue virus, foot and mouth disease virus and bovine viral diarrhea virus. The multiplex PCR primer and probe have the nucleotide sequences shown by SEQ ID No.1 to SEQ ID and No.9. The gene chip comprises a solid-phase carrier, a sample application quality control probe, a positive hybrid quality control probe and a multiplex PCR primer for detecting the bluetongue virus, foot and mouth disease virus and bovine viral diarrhea virus and the corresponding probe. In the invention, the forward primers of three viruses are marked with fluorescence, a gene chip detection technology carrying three viruses in animal fur is established based on multiplex RT-PCR (reverse transcription-polymerase chain reaction), and the RNA virus in the fur can be sensitively and specifically detected with high flux; the three viruses are screened at the same time in detection once, and the situation that a specific method is required for each virus before is changed, thereby saving the diagnosis time, meeting the needs for quick detection of mass imported / exported fur samples of the exit-entry inspection and quarantine departments and the fur import and export enterprises, and realizing relatively high application values.

The invention discloses a medical fertilizer for preventing and controlling nematodes and an application method. Betel nuts, pumpkin seeds, paris polyphylla, dahurian patrinia herb, cocklebur fruits, sophora flavescens, liquorice, pomegranate, Chinese pulsatilla roots, melia azedarach, rhizoma cibotii and other Chinese herbal medicine extracting solutions are used as a plant pesticide, compound pesticide prepared by the plant pesticide and a biological pesticide is used for preventing and controlling the nematodes, especially ditylenchus destructors harming various crops and is a low-toxicity, environment-friendly and green plant pesticide, the crop quality can be also improved, and crop yield can be improved. The medical fertilizer is a novel multifunctional ecological environment-friendly pesticide and has the active pushing effect on effective reduction of high-toxic pesticide application.

The invention provides a full-length sequence of insect chitin deacetylate enzyme genes 1 (CDA1) and an application of the insect chitin deacetylate enzyme genes 1 in farm pest control. A fragment of the chitin deacetylate enzyme genes 1 is acquired from a migratory locust transcriptome by virtue of a bioinformatics method, and the full length of the gene with the sequence of SEQ ID NO.1 is further acquired. The dsRNA of the gene is designed and synthesized according to the sequence SEQ ID NO.1, and after the dsRNA is injected into a migratory locust body cavity, a target gene can be specifically silenced, so that the old skin of the migratory locust is difficult to remove, and the migratory locust dies. The death rate reaches more than 94.7 percent by virtue of a plurality of experiments. Due to the specificity and high-efficiency death rate, the important significance for the pest control can be realized, and a novel way can be provided for the pest control.

The invention discloses application of beauveria brongniartii SB010 in the prevention and treatment of thrips. The strain SB010 is preserved in the Guangdong Microbiological Culture Collection Centeron April 19, 2018, and the preservation number is GDMCC NO:60359. The strain SB010 can effectively inhibit the thrips vulgatissimus halidayris population, is safe for human, animals, plants and environments, can partially replace pesticides for preventing the thrips, and has a great application potential in the biological prevention and control.

The present invention is one kind of pesticide composition containing fipronil and one or several pesticides selected from methylamino abamectin benzoate, triazophos, high effect cypermethrin, etc. and possesses pesticidal activity. The pesticide composition of the present invention may be used effectively in preventing and killing various agricultural and garden pests, especially pests in rice field, such as striped rice borer, yellow rice borer, rice hopper, etc. The present invention belongs to the field of agricultural and gardening technology.

The present invention relates to a kind of medicine composition, and its preparation process and application. The said medicine composition contains mainly bilobalide and paeoniflorin. The medicine composition of the present invention may be used in treating and preventing diabetes, senile dementia and cardiac and cerebral vascular diseases and in preventing recurrence of cardiac and cerebral vascular diseases.

The invention belongs to the technical field of cross of medicine and engineering and relates to an in-situ laser pulse artery opening device and application thereof. The in-situ laser pulse artery opening device comprises aorta covered stents including the Valiant stent, the zenith flex stent, the Ankura chest aorta covered stent and the chimney stent and a laser. According to the in-situ laser pulse artery opening device, after the aorta covered stents are released, according to the blood vessel condition, the aorta covered stents corresponding to branch blood vessels can be opened through the laser, and the covered stents or bare stents are planted into the opened branch blood vessels to rebuild blood flows of the branch blood vessels and reduce occurrence of relevant complications. According to the in-situ laser pulse artery opening device, the covered stents of standard specifications are adopted, no anatomical structure is destroyed, a stent system does not need to be customized independently according to the individual special anatomical form, and the in-situ laser pulse artery opening device can be used for treating aortic aneurysm or aortic dissection diseases.

The present invention discloses a new lecanicillium bacteria genus fungi specie providing pathogenicity for diaphorina citri, wherein lecanicillium sp. ZJLSP07 is preserved and registered in the China General Microbiological Culture Collection Center (CGMCC) in June 24, 2013, and the preservation number is CGMCC No.7803. The lecanicillium sp. ZJLSP07 provides pathogenicity for diaphorina citri, provides a stronger effect compared with the lecanicillium lecanii in the same specie, and can be developed as a biocontrol bacteria preparation for biological prevention and control of diaphorina citri, wherein the preparation has characteristics of high efficiency, low toxicity, low residue, no pollution, drug resistance production resistance and the like compared with the current diaphorina citri prevention and control chemicals.

The invention discloses new use of lauric acid in prevention and control of meloidogyne incognita. According to the new use, the lauric acid is used for preparing a meloidogyne incognita insecticide; and in the insecticide, the lauric acid can be separately used as an active ingredient, and can also be compatible with other active ingredients for preventing and controlling the meloidogyne incognita to form an active ingredient. The insecticide is a methanol solution of the lauric acid, the insecticide is a repellent or an attractant, and the concentration of the lauric acid in the repellent is 4.00mM; and the concentration of the lauric acid in the attractant is 0.5 to 2.00mM. The methanol solution of the lauric acid used for preventing and controlling the meloidogyne incognita is safe, nontoxic and effective; when the concentration of a lauric acid solution is 4.00mM, the meloidogyne incognita can be repelled, and the lethality of the meloidogyne incognita is up to 67 percent; and when the concentration of the lauric acid solution is 0.5 to 2.00mM, the meloidogyne incognita can be attracted, and the lethality of the meloidogyne incognita reaches 39 percent.

The invention relates to primers for differential diagnosis of a porcine epidemic diarrhea virus virulent strain and attenuated strain and a detection kit thereof, and belongs to the field of biotechnology. Total RNA is used as a template, the detection primers for differential diagnosis of the porcine epidemic diarrhea virus virulent strain and attenuated strain are used for RT-PCR amplification, and after the reaction is finished, a result is judged according to the amplified fragment number and the amplified fragment molecular weight range. The primers have good specificity, the detection method is fast and simple, the accuracy is high, and a guarantee is provided for the differential diagnosis of the porcine epidemic diarrhea virus virulent strain and attenuated strain.

The invention discloses a pancreas cancer prevention use of polycyclic fused macrocyclic lactam compounds. The structural formula of the polycyclic fused macrocyclic lactam compounds is shown in the description; and in the formula, R1 is OCH3 or H, R2 is Cl or OH, and R3 is OCH3 or H. The polycyclic fused macrocyclic lactam compounds are separated through separating and purifying a fermentation liquid of Streptomyces xiamenensis CGMCC No.4.3534 from mangrove soil. Prepared ikarugamycin and derivatives thereof can inhibit proliferation and vitality of human pancreas cancer cells, and can be used to prepare pancreas cancer prevention drugs.

The invention relates to an RT-PCR kit and a method for evaluating the concurrent intestinal cancer susceptibility of a hyperglycemia population by using the kit, belonging to the technical field of real-time fluorescence quantitative reverse transcription polymerase chain reaction kit development and human pathology combination. RT-PCR primers for detecting the transcriptional level of NOX1 mRNA in serum include a primer F: 5'-ATAGCAGAAGCCGACAGG-3' and a primer R: 5'-CCAGTGAGACCAGCAATG-3'. The invention establishes a method for detecting NOX1 mRNA in peripheral vein serum by using the specific primers; and a quantitative PCR amplification technology is adopted in the method, so that the sensitivity for detecting NOX1 mRNA is greatly improved, and enough information can be obtained in extremely few specimens.

The invention belongs to the field of traditional Chinese medicine preparation, relating to application of monomer gentiamarin extracted in the traditional Chinese medicine in preparing medicine for preventing and treating acute pancreatitis. In the invention, a model which is recognized by academic circles at home and abroad and is formed by continuously injecting caerulein to cause the acute pancreatitis of mice in enterocoelia and carrying out bezoar sodium taurocholate retrograde injection in cholangiopan so as to cause the acute pancreatitis of a rat, is adopted to study the action of the gentiamarin. The experiment result discloses that the gentiamarin has obvious function of resisting the acute pancreatitis caused by various reasons, and the action mechanism for resisting the acute pancreatitis is related to the releasing of the inflammatory factor, reduction of concentration of the tumor necrosis factor-alpha and interleukin-1beta in the serum or tissue, the increasing of the glutathione peroxidase activity in the serum or tissue, and the clearing of the radical and the expression of NF-kB P65.

The invention relates to a medicament for treating lung cancer. Tortoise plastron, turtle shell, ginseng, radix codonopsitis, radix pseudostellariae, pilose antler, root of rehmannia, dioscoreae opposite thumb, angelica, tuckahoe, tokay, cortex moutan, red paeony root, gardenia, rhizoma anemarrhenae, phellodendron amurense, figwort, concocted pangolin, alisma, Chinese eaglewood, radix astragali, cordyceps, pepperweed seed and Szechuan-fritillary bulb are evenly mixed and crushed into fine powder of 100 to 120 meshes; and the fine powder is pressed into tablets. The medicament has the advantages of nourishing kidney-Yin, warming kidney-Yang, benefitting vigor, clearing the lung and moistening dryness, unchoking mechanism of Qi, nourishing the blood and clearing Ying heat, breaking obstruction and relieving tumor, and clearing away heat and toxic material, applies cold and heat, combines tonification and purgation, and can enhance autoimmune function of human body, activate immune cells, promote nutrient recovery of tissues and cells, relieve and alleviate clinical symptoms, improve life quality of patients, and prolong life of the patients.

The invention relates to a group of coxsackie group A 6 virus mutant strains and application thereof, the group of the coxsackie group A 6 virus mutant strains comprises a strong virulence mutant strain and a weak virulence mutant strain, and the strong virulence mutant strain contains the following loci in a single or arbitrary combination: VP1 protein: 124M and 242V, VP2 protein: 57D and VP3 protein: 135P. The attenuated mutant strain contains the following loci in a single or arbitrary combination: VP1 protein: 124V and 242I ,VP2 protein: 57D and VP3 protein:135P.

Discloses is a process for producing α-D-glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]- or 1-(dihydrogen phosphate) tetrasodium salt which is useful as an active ingredient of a pharmaceutical or an intermediate for the synthesis thereof, which is environment-friendly and excellent in safety, operationality and reproducibility. A process for producing a compound represented by the formula (I) comprising the steps of reacting a compound represented by the formula (VIII) with a palladium catalyst in the presence of a nucleopholic agent and treating the product with a sodium source.

The invention relates to a brass alloy with a macro-hole, micron-hole and nano-hole hierarchical hole structure and application thereof. The alloy is prepared through the following method including the following steps that (1) a via hole array perpendicular to the surface is formed on a brass cylinder through processing by means of a numerical control processing technology, and then the processed brass cylinder is cleaned and dried; and (2) the obtained multi-hole brass alloy cylinder with the via hole array in the first step is soaked in a nitric acid solution with the mass concentration being 4.5%-6.5%, de-alloying treatment is performed for 10-30 minutes at the temperature of 35-40 DEG C, and the brass alloy with the macro-hole, micron-hole and nano-hole hierarchical hole structure is obtained after cleaning and drying. According to the brass alloy with the macro-hole, micron-hole and nano-hole hierarchical hole structure and the application thereof, the material porosity and specific surface area are increased, and meanwhile, the compression performance is still kept at high level. The fatality rate of escherichia coli and staphylococcus aureus can reach 100% to the maximum degree.

The invention discloses an application of a [1,2,4]triazolo[4,3-B]pyridazine derivative as shown in a formula (I) and a pharmaceutically acceptable salt or polymorphic substance thereof in preparationof anti-inflammatory factor storm drugs. According to the invention, the compounds can inhibit the expression and secretion of a variety of inflammatory factors by up-regulating let-7 expression, especially, expression and secretion of key factors IL-1RA, IL-1alpha, IL-1beta, IL-6, IL-10, IL-18, IL-22, IP-10, CCL2, GM-CSF, TNF-alpha and the like which form inflammatory factor storm, have good drug safety and strong inflammatory factor inhibition effect, and can be used as candidate drugs for resisting inflammatory factor storm.

The invention discloses application of a 2-furan acrylaldehyde compound to preparation of a medicine for resisting human gamma-herpes virus. The 2-furan acrylaldehyde compound provided by the invention can be used for inhibiting lytic replication of the human gamma-herpes virus; compared with a marketing drug, namely acyclovir, the 2-furan acrylaldehyde compound has relatively small toxicity and the activity is equivalent. Therefore, the compound has a good application prospect in treatment of related diseases caused by KSHV (Kaposi's Sarcoma-associated Herpesvirus) and EBV (Ebola Virus) infection.

The invention discloses a medical nanofiber with sterilization and waterproof functions. The medical nanofiber comprises the following components of, in parts by weight, 60-70 parts of chitosan, 25-30parts of polylactic acid, 20-25 parts of titanium dioxide, 10-15 parts of nano-silver, 30-40 parts of sterilization liquid, 10-14 parts of formic acid, 10-12 parts of distilled water and 2-5 parts ofsilane coupling agent. According to a production process of the medical nanofiber with the sterilization and waterproof functions, bacteria attached to a nanofiber woven product are killed by using traditional Chinese medicines, so that the medical nanofiber is harmless to a human body and meets the medical standard, meanwhile, the woven product is formed by weaving nanofibers, water cannot be attached and can be easily shaken off, and the fatality rate of escherichia coli, staphylococcus aureus, candida albicans and salmonella attached to the woven surface is high.

The invention provides Metarhizium rileyi and a biological control method and application of Metarhizium rileyi in a pupal stage of spodoptera frugiperda, and belongs to the technical field of microorganisms. The preservation number of the Metarhizium rileyi FJMR2 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No.18553. The Metarhizium rileyiFJMR2 provided by the invention has strong pathogenicity to spodoptera frugiperda pupae, can obviously reduce the eclosion rate of the spodoptera frugiperda pupae, has higher teratogenesis rate and fatality rate to eclosion adults, can effectively control the increase of the population number of the spodoptera frugiperda, and is environment-friendly and safe to human and livestock. The Metarhizium rileyi FJMR2 provided by the invention can solve the technical problems that in the prior art, chemical pesticides are adopted for preventing and controlling the spodoptera frugiperda, the environment is polluted, drug resistance is easily generated, and underground pupae are difficult to prevent and control.

The invention belongs to the technical field of biological Helicoverpa armigera prevention and control, and particularly relates to a method for improving the biological Helicoverpa armigera prevention and control effect of nuclear polyhedrosis viruses (NPVs). The method can improve the Helicoverpa armigera prevention and control effect of NPVs through the feeding of a Helicoverpa armigera C-type lectin dsRNA (double-stranded ribonucleic acid) (Ha-lectin1 dsRNA); the Helicoverpa armigera prevention and control effect of NPVs can be remarkably improved at a dosage of 3 micrograms of Ha-lectin1 dsRNA and 50 PIBs (polyhedral inclusion bodies) of NPVs per larva of Helicoverpa armigera. The method provided by the invention has a fast onset of insect killing, that is, the time of Helicoverpa armigera death caused by Helicoverpa armigera NPVs (HaNPVs) can be shortened by 1 / 3; the insect killing efficiency is high, that is, the killing rate in the first three days can be increased by 35 percent; the consumption is low, that is, the use consumption of NPVs can be greatly reduced. Compared with the method which simply uses NPVs for Helicoverpa armigera prevention and control in the prior art, the method provided by the invention achieves remarkable improvements.

The invention discloses a pseudomonas aeruginosa sanitizer applicable to production of barreled drinking water and a sterilization method and relates to the technical field of sterilization and disinfection. The pseudomonas aeruginosa sanitizer comprises a main sterilization component, a sterilization accelerant and a solvent, wherein the main sterilization component is selected from one of hydrogen peroxide and chlorine dioxide; if the hydrogen peroxide is adopted as the main sterilization component, the concentration of the hydrogen peroxide in the pseudomonas aeruginosa sanitizer is 0.4-0.72g / L; when the chlorine dioxide is adopted as the main sterilization component, the concentration of the chlorine dioxide in the pseudomonas aeruginosa sanitizer is 0.192-0.48mg / L; the sterilization accelerant is one or a mixture of more than any two of FeCl3, CuSO4 and ZnSO4; the concentration of the sterilization accelerant in the pseudomonas aeruginosa sanitizer is 1.9-2.1mmol / L; the solvent iswater; and the pseudomonas aeruginosa sanitizer is a sanitizer which is prepared and used in situ. The sanitizer is high in security and high in fatality rate upon pseudomonas aeruginosa, and the sterilization speed of the sanitizer is greatly increased when being compared with those of conventional sanitizers of single components.

The invention relates to platinum-copper nanocrystals as a tumor photothermal ablation diagnosis and treatment agent and a preparation method thereof, and belongs to the technical field of nano biomaterials. The platinum-copper bimetallic nanocrystals have the particle size in a range of 5-200 nm and have the basic structure of PtCun, wherein n is in the range of 0-5; the morphology has one or more of cube, sphere, snowflake shape, and lamellar shape. The platinum-copper nanocrystals can be applied to near infrared light mediated tumor photothermal ablation, and are applicable to the near infrared light wavelength range of 700-1100 nm. The platinum-copper nanocrystals are prepared by a pyrolysis method, and in a high-boiling-point oil phase medium, the snowflake-shaped platinum-copper bimetallic nanocrystals are prepared by metal precursor thermal reduction decomposition. The nanocrystals have the advantages of low cost, simple preparation, high purity, good crystal shape, controllable particle size and regular shape, are used as a near infrared photothermal conversion agent to be applied to tumor photothermal ablation, have obvious effect, and provide a research direction for tumor therapy.

The invention belongs to the technical field of pesticide processing and in particular relates to a roxburgh rose insect and disease prevention and control chemical which comprises the following raw materials: fresh lemon peel, celery, rabdosia rubescens, atractylodes macrocephala and campsis grandiflora. Through special formulae and preparation processes, the fatality rate of the chemical provided by the invention to aphids is as high as 92.5%, the inhibition rate of the chemical to powdery mildew pathogenic bacteria is as high as 90.6%, the inhibition rate of the chemical to brown blotch pathogenic bacteria is 95.6%, and the chemical belongs to broad spectrum, low-toxicity and high-efficiency chemicals.

The invention discloses a spodoptera frugiperda insecticide as well as a preparation method and application thereof. The insecticide comprises at least one microbial agent and at least one synergist,wherein the microbial agent consists of bacillus subtilis and a nutritional agent required by the bacillus subtilis; the synergist comprises at least one plant saponin extract. The preparation methodof the insecticide comprises the steps: mixing and fermenting the microbial agent, the nutritional agent and water, and mixing the obtained fermentation liquor with the synergist according to a certain proportion. In practical application, the insecticide can be sprayed to crops, including foliage spraying, ground spraying, flood irrigation and the like. The method has a good prevention and control effect on field pests (especially spodoptera frugiperda), is free of pesticide addition, does not enable crops to generate drug resistance, and has great significance in preventing and controlling spodoptera frugiperda and protecting grain production safety in China.

The invention discloses a traditional Chinese medicine effective part composition with the effect of treating ischemic cerebral apoplexy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The composition of the medicine comprises raw herbal materials including hirudo, fructus corni, ginkgo leaf and the root of kudzu vine, and effective parts are extracted by water and alcohols with different concentrations according to different properties of the medicine, and are prepared into pills, tablets or soft capsules. The medicine composition has effects of invigorating the circulation of blood, removing blood stasis, promoting the circulation of qi and protecting blood vessels of the brain of a patient, and is mainly used for treating ischemic cerebral apoplexy.

The invention discloses an application of a polymer as a synergist of a chemotherapy drug. The polymer contains a 1,2-dicarboxylic acid mono-amide structure. After the polymer, a chemotherapy drug, and cancer cells are co-cultured in a slightly acidic environment of simulated tumor tissues, the survival rate of cancer cells is lower than the survival rate of cancer cells that are not subjected toco-culture under same conditions; and after the polymer and the chemotherapy drug are injected into cancer bearing animals, the effect on inhibiting tumor growth is better, compared with the situationthat only the chemotherapy drug with a same dose is injected.

The invention relates to an RNAi vector for expressing the dsRNA of a gene HaAK in a transgenic plant and application of the RNAi vector, and belongs to the field of agricultural biotechnologies. The invention provides a method for controlling helicoverpa armigera by selecting a helicoverpa armigera energy metabolism key enzyme gene arginine kinase gene HaAK as a target gene of RNAi. The invention particularly relates to an RNAi vector for expressing the dsRNA of helicoverpa armigera HaAK in the transgenic plant and the application of the RNAi vector to a silent target gene. The vector is constructed by inserting two HaAK segments into a plant expression vector in two opposite directions; and the transgenic plant expressing the dsRNA of the gene HaAK is cultivated under agrobacterium mediation. The comparison between the transgenic plant and a wide plants shows that the growth and development of helicoverpa armigera eating the transgenic plant can be affected.