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Hirudo small peptide medicine for treating ischemic cerebral apoplexy

A technology for ischemic stroke and leeches, applied in drug combinations, medical raw materials derived from leeches/worms, pharmaceutical formulas, etc., can solve the problems of large dosage, low ingredient content, and poor efficacy, and achieve remarkable results , protect the body's immunity and improve the body's immunity

Inactive Publication Date: 2016-01-27
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The active part and effective part group of traditional Chinese medicine have an ingredient content of more than 50%, and the active ingredient content is very high, which is helpful for the treatment of diseases and the effect of the drug; while the traditional Chinese medicine compound has a low ingredient content, large dosage, and high efficacy. poor

Method used

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  • Hirudo small peptide medicine for treating ischemic cerebral apoplexy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Prescription: leech small peptide 60g, total glycosides of cornel 50g, total lactones of ginkgo biloba 50g, total flavonoids of kudzu root 30g.

[0056] Preparation method: Preparation of small leech peptides: Take leeches, crush them properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 30 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 5% of the substrate Pepsin, hydrolyze at 37°C for 4 hours, then use sodium hydroxide solution to adjust the pH to 7-10, add trypsin with 5% substrate amount, and hydrolyze at 50°C for 4 hours, stir constantly and adjust the pH at In the range of 7 to 10, continue to heat up and boil for 15 minutes after the enzymolysis is completed, let it cool, centrifuge, collect the supernatant, adjust the pH to 6.5 to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate uses the cut-off relative molecular mass Perform ultrafiltration for a 3kD ...

Embodiment 2

[0062] Prescription: 120g of small leech peptides, 100g of total glycosides of Cornus officinalis, 100g of total ginkgo biloba lactones, and 60g of total flavonoids of kudzu root.

[0063] Preparation method: Preparation of small leech peptides: Take leeches, crush them properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 30 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 5% of the substrate Pepsin, hydrolyze at 37°C for 4 hours, then use sodium hydroxide solution to adjust the pH to 7-10, add trypsin with 5% substrate amount, and hydrolyze at 50°C for 4 hours, stir constantly and adjust the pH at In the range of 7 to 10, continue to heat up and boil for 15 minutes after the enzymolysis is completed, let it cool, centrifuge, collect the supernatant, adjust the pH to 6.5 to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate uses the cut-off relative molecular mass Perfo...

Embodiment 3

[0069] Prescription: 120g of small leech peptides, 100g of total glycosides of Cornus officinalis, 100g of total ginkgo biloba lactones, and 60g of total flavonoids of kudzu root.

[0070] Preparation method: Preparation of small leech peptides: Take leeches, crush them properly, add 10 times the amount of water to homogenate for 15 minutes, heat and boil for 30 minutes, let cool to room temperature, use hydrochloric acid to adjust the pH to 2.0±0.1, and then add 5% of the substrate Pepsin, hydrolyze at 37°C for 4 hours, then use sodium hydroxide solution to adjust the pH to 7-10, add trypsin with 5% substrate amount, and hydrolyze at 50°C for 4 hours, stir constantly and adjust the pH at In the range of 7 to 10, continue to heat up and boil for 15 minutes after the enzymolysis is completed, let it cool, centrifuge, collect the supernatant, adjust the pH to 6.5 to 7.0, add 2% activated carbon, stir evenly, filter, and the filtrate uses the cut-off relative molecular mass Perfo...

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Abstract

The invention discloses a traditional Chinese medicine effective part composition with the effect of treating ischemic cerebral apoplexy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The composition of the medicine comprises raw herbal materials including hirudo, fructus corni, ginkgo leaf and the root of kudzu vine, and effective parts are extracted by water and alcohols with different concentrations according to different properties of the medicine, and are prepared into pills, tablets or soft capsules. The medicine composition has effects of invigorating the circulation of blood, removing blood stasis, promoting the circulation of qi and protecting blood vessels of the brain of a patient, and is mainly used for treating ischemic cerebral apoplexy.

Description

technical field [0001] The present invention relates to a composition of effective parts of traditional Chinese medicine with the effect of treating ischemic cerebral apoplexy and a preparation method thereof, in particular to a composition of effective parts of traditional Chinese medicine extracted from leeches, dogwood, ginkgo leaves and kudzu root and a preparation method thereof, belonging to The field of traditional Chinese medicine. Background technique [0002] Cardiovascular diseases, cerebrovascular diseases and malignant tumors are called the three major death diseases of human beings, and their prevention and in-depth research have always been the focus in the field of medicine. Cerebrovascular diseases Currently common cerebrovascular diseases are mainly seen in cerebral infarction, cerebral embolism, cerebral hemorrhage, vertebrobasilar artery insufficiency, and cerebrovascular malformation. The number of patients in our country has an increasing trend year by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K35/62A61P9/10A61K36/488
Inventor 代龙刘国飞
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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