The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a gynecologic skin decontamination drug and a preparation method thereof. The effective components of a gynecologic skin decontamination drug product are prepared from the following raw materials in parts by weight: 10-35 parts of tender folium artemisiae argyi, 10-40 parts of green tea, 5-30parts of flos rosae rugosae, 5-30 parts of folium mori and 1-15 parts of radix ginseng. The product has the effects of warming channels and dredging collaterals, removing dandruff and relieving itching, resisting bacteria and relieving pains, and moistening skin and whitening, and is suitable for postnatal facial pachulosis and hyperpigmentation as well as removal of stretch marks on abdomen. According to the invention, a molecular extraction technology combination of high-pressure-difference repeated fluid wall-breaking, continuous gradient molecular screening, low-temperature concentration,drying and crystallization, a near-infrared spectrum online process analysis technology, and the like is selected to remove heavy metal, pesticide residues, chemical residues and harmful components to the greatest extent, and efficiently and completely separate and extract active components, so that skin nano micro-capsule spray with proper concentration is prepared through a lipidosome technology.